A5012057486- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Colorectal Cancer Screening and Detection
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Eosinophilic Esophagitis
- Hepatitis C virus research
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Autoimmune and Inflammatory Disorders
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
Chang Gung University
2016-2025
Chang Gung Memorial Hospital
2015-2025
Memorial Hospital of South Bend
1998-2025
Linkou Chang Gung Memorial Hospital
2016-2025
Taiwan Nurses Association
2018-2024
Agaplesion Markus Hospital
2023
Goethe University Frankfurt
2023
RELX Group (Netherlands)
2018
Iredell Statesville Schools
2014
The QUASAR Phase 2b Induction Study evaluated the efficacy and safety of guselkumab, an interleukin-23p19 subunit antagonist, in patients with moderately to severely active ulcerative colitis (UC) prior inadequate response and/or intolerance corticosteroids, immunosuppressants, advanced therapy.
Abstract Background and Aim Duodenal ulcers, especially caused by increasingly drug‐resistant Helicobacter pylori , are a concern in Asia. We compared oral vonoprazan versus lansoprazole for efficacy (healing duodenal ulcers) safety non‐Japanese Asian patients. Methods In this phase 3, randomized (1:1), double‐blind, double‐dummy, parallel‐group, non‐inferiority study (April 5, 2017, to July 19, 2019), patients with ≥ 1 endoscopically confirmed ulcer, at 52 hospitals (China, South Korea,...
Importance Effects of screening for Helicobacter pylori on gastric cancer incidence and mortality are unknown. Objective To evaluate the effects an invitation to screen H mortality. Design, Setting, Participants A pragmatic randomized clinical trial residents aged 50 69 years in Changhua County, Taiwan, eligible biennial fecal immunochemical tests (FIT) colon screening. were either stool antigen (HPSA) + FIT assessment or alone. The study was conducted between January 1, 2014, September 27,...
Abstract Background Clostridium innocuum has emerged as a pathobiome with vancomycin resistance, posing challenges in inflammatory bowel disease (IBD) management. In ulcerative colitis (UC) patients, C. is associated reduced clinical remission rates, while Crohn’s (CD) it correlates creeping fat and intestinal stricture formation1,2. Some IBD patients experience refractory or recurrent infections, even after metronidazole treatment1. This study aimed to evaluate the safety feasibility of...
Abstract Ultrasonography of prospectively followed chronic hepatitis B patients who developed liver cirrhosis were reevaluated in order to identify the ultrasonographic changes early cirrhosis. Ultrasonographic features 29 before and after as follows: portal vein diameter—1.20 cm/1.29 cm (NS); score—5.69/7.52 ( p < 0.01); spleen size index—21.99 2 /25.84 (NS). The result suggests that diagnosis is not easy on a single occasion; however, score system method helpful longitudinal follow‐up...
We studied the efficacy of magnetic resonance cholangiopancreatography (MRCP) in evaluation malignant perihilar biliary obstructions, with reference to endoscopic retrograde (ERCP).A total 40 patients who underwent both MRCP (Magnetom Vision; Siemens, Erlangen, Germany; projection technique and multislice plus maximum intensity projection) ERCP examinations, were studied. The study group included hilar cholangiocarcinoma (Klatskin tumor) 26 patients, icteric hepatocellular carcinoma four...
Abstract Activated T regulatory (T reg ) cells are potent suppressors that mediate immune tolerance. We investigated the relationship between activated and progression of human colon cancer. designed a cross‐sectional study CD4 + Foxp3 from peripheral blood, primary tumor nontumor tissue 42 patients with cancer correlated percentages different subgroups stage. The phenotypes, cytokine‐release patterns suppression ability these were analyzed. found increased significantly in both blood...
The technical performance of colonoscopy performed in deeply sedated patients differs from that without sedation or under minimal to moderate sedation. aim this study is evaluate the factors affecting cecal intubation during deep sedation.A total 5352 consecutive subjects who underwent a screening as part health check-up between January 2008 and December at an academic hospital were reviewed. All endoscopies with using combination propofol alone. Data collected included characteristics (age,...
Abstract Background Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in prevalence and antimicrobial resistance H. , availability medications endoscopy. Thus, nationwide or regional needed to improve control infection gastric cancer. Materials Methods This statement Taiwan has three major sections: (1) optimal diagnosis indications; (2) current treatment strategies; (3)...
Esophagitis is the second most common gastrointestinal manifestation of cytomegalovirus (CMV) infection after colitis. CMV esophagitis has been reported in patients who have undergone transplantation, are on long-term renal dialysis, or human immunodeficiency virus infection. This study aimed to investigate clinical characteristics and manifestations underwent diagnostic endoscopy. A total 16 with histologically proven were identified from 1539 esophageal ulcers analyzed retrospectively...
In Brief Objective: To propose a cholangiographic classification for intraductal growth type intrahepatic cholangiocarcinoma (IG-ICC) and its precursor, collectively termed papillary mucinous neoplasm of the bile ducts (IPMN-B). Summary Background Data: For extensive clinicopathologic variations IPMN-B, detailed characterization cholangiography IPMN-B is beneficial determining optimal therapeutic strategy. Methods: A total 124 patients with cholangiography-available pathologically proven...
Abstract Background. Opinions regarding the impact of human epidermal growth factor receptor (HER)-2 overexpression or HER-2 amplification on prognosis gastric cancer patients are mixed. The present study attempted to clarify this issue by investigating a large cohort surgical patients. Methods. We investigated 1,036 undergoing curative-intent resection. Their specimens were evaluated for expression immunohistochemistry (IHC), and those with levels 2+ additionally subjected fluorescence in...
The present study assessed the impact of retrieval >25 lymph nodes (LNs) on survival outcome patients with advanced gastric cancer after curative-intent gastrectomy.A total 5,386 who had undergone curative gastrectomy for from 1994 to 2011 were enrolled. clinicopathological parameters and overall (OS) analyzed according number LNs examined (≤15, n = 916; 16-25, 1,458; >25, 3,012).The percentage retrieved increased 2011. Patients in LN group more likely have a larger tumor size, poorer...
Abstract Background and Aim Epstein–Barr virus (EBV) is suggested to actively utilize its ebv‐microRNAs (miRNAs) manipulate viral cellular functions during neoplasia transformation. A systemic profiling of ebv‐miRNAs expressed in EBV‐associated gastric carcinoma (EBVa GC) helps understand epigenetic regulation carcinogenesis. Methods total 1039 patients with cancer were screened for EBVa GC using EBV‐encoded RNAs situ hybridization. comprehensive was constructed stem‐loop quantitative...
Cytomegalovirus (CMV) infection of the gastrointestinal (GI) tract can be fatal. However, very few studies have provided comprehensive analyses and specified differences in symptoms observed different parts GI tract. This study aimed to comprehensively analyze clinical manifestations management CMV disease. retrospective cohort enrolled patients who had diseases proved by immunohistochemistry stain from pathology database a 4000-bed tertiary medical center between January 2000 May 2021. The...
Background The burden of gastroesophageal reflux disease (GERD) is increasing in the Asia area and majority GERD patients have non-erosive (NERD). Aim To evaluate efficacy safety sodium alginate suspension compared to omeprazole adult subjects with NERD. Methods In this 4-week, double-blind, parallel study, 195 NERD were randomised one two treatment groups: 20 mL three times a day mg once daily. primary endpoint was percentage achieving adequate heartburn or regurgitation relief at 28...
This study investigated the antimicrobial resistance of isolates from patients with refractory Helicobacter pylori. The rate was 34.1% for amoxicillin, 92.7% clarithromycin, 65.9% metronidazole, 85.4% levofloxacin, and 29.3% rifabutin. Dual to both clarithromycin levofloxacin found in 73.2%. H. pylori extremely high, which had become a major consideration therapeutic challenge.
OBJECTIVES There is no reliable parameter to predict the late mortality of patients with severe acute pancreatitis though it an important issue. Recently a proposed for "immunoparalysis," down-regulation Human Leukocytes Antigens-DR (HLA-DR) expression on monocytes, had been detected in but not mild pancreatitis. However, relationship between this and still unclear. Therefore, we conducted study order elucidate METHODS Twenty-five admitted Chang-Gung Memorial Hospital were successively...
Alterations of adipocytokine levels and clinical parameters in non-alcoholic fatty liver disease (NAFLD) are crucial for the prognosis complications diseases. However, key adipocytokines independently associated with NAFLD have not been identified, we aimed to investigate them.This study was conducted on a consecutive series 210 Taiwanese patients 420 sex- age-matched controls. Fatty diagnosed by magnetic resonance spectroscopy. The enrolled subjects' body mass indexes, homeostasis model...
Abstract Reports suggest that between 25% and 80% of patients with Streptococcus bovis / gallolyticus bacteremia have concomitant colorectal tumors. This retrospective study was aimed to identify associations clinical characteristics a finding neoplasm in S. who had colonoscopy examination. We retrospectively reviewed the records from Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, January 2004 2014. Clinical data including age, sex, comorbidities, blood culture, findings were...
Abstract Purpose The use of microsatellite instability (MSI) and mismatch repair (MMR) as predictive biomarkers for fluorouracil-based adjuvant chemotherapy in colorectal cancer has been a paradigm shift. However, whether this applies to gastric is questionable. Furthermore, we herein investigated how autophagy plays role MSI-relevant chemoresistance. Materials Methods A total 929 patients with deficient MMR (dMMR) proficient (pMMR) cancers who underwent curative-intent gastrectomy were...
Abstract Background Etrasimod (ETR) is an oral, once daily (qd), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). ES101002 was a registrational Phase (Ph) 3 study evaluating efficacy and safety ETR in Asian patients (pts) with UC (NCT04176588). has shown significant benefit vs placebo (PBO) as induction maintenance therapy pts UC, including 12-week (wk) period (IP) ES101002.1–4 Here, we report results...