A5042603116- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone Metabolism and Diseases
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Bone health and treatments
- Diagnosis and treatment of tuberculosis
- Digital Radiography and Breast Imaging
- Gastroesophageal reflux and treatments
- Microscopic Colitis
- Neurological Disease Mechanisms and Treatments
- Renal Diseases and Glomerulopathies
- Inflammatory Bowel Disease
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
- Obstructive Sleep Apnea Research
- Glycosylation and Glycoproteins Research
- Chemokine receptors and signaling
- Electrospun Nanofibers in Biomedical Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Aortic Disease and Treatment Approaches
- Cerebrovascular and Carotid Artery Diseases
Peking University People's Hospital
2016-2025
Peking University
2016-2025
Karolinska Institutet
2016-2024
Science for Life Laboratory
2024
KTH Royal Institute of Technology
2024
China Medical University
2024
Karolinska University Hospital
2016-2017
Shanghai Medical College of Fudan University
2014
Background Mammographic density measurements are used to identify patients who should undergo supplemental imaging for breast cancer detection, but artificial intelligence (AI) image analysis may be more effective. Purpose To assess whether AISmartDensity—an AI-based score integrating signs, masking, and risk—surpasses of mammographic in identifying after a negative screening mammogram. Materials Methods This retrospective study included randomly selected individuals underwent mammography at...
Abstract Background Etrasimod (ETR) is an oral, once daily (qd), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). ES101002 was a registrational Phase (Ph) 3 study evaluating efficacy and safety ETR in Asian patients (pts) with UC (NCT04176588). has shown significant benefit vs placebo (PBO) as induction maintenance therapy pts UC, including 12-week (wk) period (IP) ES101002.1–4 Here, we report results...
Aberrant CXC chemokine receptor 4 (CXCR4) expressions in malignant tissues have been reported; however, its role kidney cancer prognosis remains unknown. The aim of this study was to determine the prognostic value CXCR4 expression patients with clear-cell renal cell carcinoma (ccRCC).The included 225 ccRCC. cohort split into a training set (n=125) and validation (n=100). analysed by immunohistochemical staining correlations clinicopathologic features were evaluated.CXCR4-staining intensity...
Antibodies against carbamylated protein (anti-CarP) were found to be a promising marker evaluate joint damage and disease activity in patients with rheumatoid arthritis (RA). However, whether anti-CarP antibodies present systemic lupus erythematosus (SLE) remained ambiguous. We have therefore undertaken this study assess the levels of serum their clinical value SLE.Serum carbamylated-vimentin (anti-Carp) measured by enzyme immunosorbent assay 100 SLE, 76 RA, 17 primary Sjögren syndrome...
Abdominal aortic aneurysm (AAA) is a progressive disease featured by inflammation, vascular smooth muscle cells (VSMCs) depletion, and elastin degradation. MicroRNAs were related to AAA formation, which bring the approach for precise targeted drug therapy AAA. We developed new strategy based on decellularized adipose matrix (DAM) hydrogel immobilized adventitia release antagomiR-150-5p preventing development. In this study, Cacl2-induced elastase-induced rat models established. found that...
To evaluate ultrasonic features of the major salivary glands in patients with immunoglobulin G4-related sialadenitis (IgG4-RS) and to explore differences between IgG4-RS Sjögren's syndrome (SS).We conducted study 150 100 SS. Ultrasonographic variables static images were analysed. An experienced radiologist scored confidence rating regarding presence characteristic imaging findings using a five-grade system. Ultrasonography scores SS compared.The significantly larger than group. The main...
<h3>Background and objectives</h3> Circulating levels of IL-8 is related to the bone loss associated with breast cancer metastasis. Recently, we have shown that anti-citrullinated protein antibodies (ACPA) can induce osteoclastogenesis. We aimed investigate role its receptors in mediating osteoclastogenesis presence or absence ACPAs <h3>Methods</h3> was measured by ELISA serum risk RA patients synovial fluid samples patients. CD14 positive monocytes were used generate osteoclasts M-CSF...
Abstract Background The incidence of inflammatory bowel disease (IBD) is increasing year by and the mechanism unclear. A great number studies have shown that gut microbiota composition IBD patients has changed diversity decreases. abundance firmicutes decreases, Proteobacteria increases, which eventually leads to immune disorders intestinal inflammation. mouth "gateway" digestive tract, various microbiota. entry extraneous from into intestines play an important role in influencing continuous...
套细胞淋巴瘤是B细胞非霍奇金淋巴瘤的特殊类型。异基因造血干细胞移植通常被用于部分高危（例如TP53突变）患者及难治复发套细胞淋巴瘤患者的治疗。近年随着新的治疗手段，如布鲁顿酪氨酸激酶抑制剂、嵌合抗原受体T细胞疗法等显著改善了套细胞淋巴瘤患者的预后，使得异基因造血干细胞移植在套细胞淋巴瘤治疗中的地位有所下降，但异基因造血干细胞移植仍是难治/复发套细胞淋巴瘤患者重要的治疗手段之一。本文对异基因造血干细胞移植治疗套细胞淋巴瘤的现状及其未来治疗地位和趋势进行综述。.
A 19-year-old male patient with high-risk acute B-cell lymphoblastic leukemia received haploidentical stem cell transplantation. He developed anemia repeatedly and parvovirus B19 nucleic acid was positive in blood plasma. The diagnosed cold agglutinin syndrome multiple organ dysfunction including respiratory failure hepatitis. In the conflict between viral infection treatment of syndrome, we provided supportive treatment, complement inhibitors to control hemolysis, antiviral therapy. After...
Objective: To investigate the characteristics of T cell immunophenotype and its relationship with clinical manifestation in patients systemic light chain amyloidosis (AL) . Methods: The peripheral blood mononuclear cells from 36 AL were collected analyzed by multicolor flow cytometry, expression surface antigen CD3, CD56, CD4, CD8, CD25, CD45RA, CD28, CD57 nuclear FOXP3 examined. Samples 28 age-matched healthy donors (HD) also Patients divided Mayo 2012 staging system difference between Ⅰ-Ⅱ...
Objective: To explore the efficacy and safety of BCL-2 inhibitor-based treatment in patients with relapsed/refractory t (11; 14) primary systemic light chain amyloidosis. Methods: This was a retrospective case series study. Ten t(11;14) amyloidosis who had all received combination regimen including inhibitor venetoclax from January 2018 to November 2022 at Hematology Department Peking University People's Hospital were included. Adverse events, hematological organ responses evaluated....
<h3>Background</h3> We have shown previously in various experimental models that anti-citrullinated protein antibodies (ACPAs) can contribute to bone erosion and arthralgia through IL-8 dependent mechanisms. <h3>Objectives</h3> In cell cultures osteoclasts (OCs) played a prominent role the ACPA-induced secretion therefore we decided characterize detail autocrine regulation of OC differentiation by presence or absence ACPAs. <h3>Methods</h3> Peripheral blood CD14-positive monocytes were used...
Objective:To assess the role of LPR in development complications, such as hemorrhage, following tonsillectomy adult patients. We want to provide a guidence for future clinical practice.Method:Totally 70 patients who had indication were recruited and divided into two groups, laryngopharyngeal reflux (LPR) group control group, which identified by results Reflux Symptom Index (RSI) Finding Score (RFS). observed compared postoperative complications groups analyzed LPR.Result:All complained pain...
Objective: To investigate the clinical manifestations and prognosis of multiple myeloma (MM) patients with t(8;14)(q24;q32). Methods: The data MM G-banding results from 2004 to 2009 in Hematology Department People's Hospital Peking University were retrospectively analyzed. general data, M protein related examination, cytogenetics therapeutic regimen response evaluation t(8;14)(q24;q32) collected. Results: Of all newly diagnosed patients, number who had was 940, among which 265 abnormal...
Objective: To look into the security of a second allogeneic hematopoietic stem cell transplantation (allo-HSCT) using rabbit anti-human thymocyte immunoglobulin (rATG) . Methods: Twenty-seven patients who used rATG in first and allo-HSCT at Institute Hematology, Peking University were enrolled study. Experienced toxicities associated with conditioning protocol within 10 days (-5 d to +3 d) following beginning application, including fever, diarrhea, arrhythmia, reduced blood pressure, liver...
Objective: To explore the associations of urinary retinol binding protein (RBP) and β2-microglobulin (β2-MG) with albumin to creatinine ratio (UACR) renal function in hospitalized patients type 2 diabetes mellitus (T2DM). Methods: A total 1 030 Chinese T2DM were included this study. The subjects divided into UACR normal group ( 300 mg/g). Patients further two groups according estimated glomerular filtration rate (eGFR): eGFR low 0.7 mg/L) β2-MG (>370 μg/L) these 3.8%, 8.5%, 39.0% (P 370 was...
Objective: To analyze the efficacy and safety of Daratumumab for treatment primary AL light chain systemic amyloidosis. Methods: Twenty one patients who were diagnosed as amyloidosis treated with from 7 centers retrospectively analyzed. was administrated first line therapy in seven 14 relapsed settings. Hematological response, survival Results: All achieved very good partial response (VGPR) or better first-line application daratumumab. Three died, other four organ remission. Among patients,...