A5100319479- Kidney Stones and Urolithiasis Treatments
- Aortic Disease and Treatment Approaches
- Pediatric Urology and Nephrology Studies
- Aortic aneurysm repair treatments
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Urinary Tract Infections Management
- Prostate Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cerebrovascular and Carotid Artery Diseases
- Lung Cancer Treatments and Mutations
- Infectious Aortic and Vascular Conditions
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Cardiac tumors and thrombi
- Urinary Bladder and Prostate Research
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Peking Union Medical College Hospital
2022-2025
Dalian University of Technology
2025
China Medical University
2014-2025
Zhejiang University
2025
Shantou University
2022-2025
South China University of Technology
2024-2025
Fudan University
2025
State Key Laboratory of Genetic Engineering
2025
Army Medical University
2025
Docetaxel is the first-line chemotherapy agent for metastatic prostate cancer.However, emergence of resistance diminishes its efficacy and limits survival benefit.Quercetin a dietary flavonoid which has been shown to have multiple anti-cancer effects.Also, quercetin reported reverse chemo-resistance in many other cancers.This study was determine whether could docetaxel cancer cells xenograft models, thereby exploring underlying mechanism.Depending on docetaxel-resistant (LNCaP/R, PC-3/R)...
Carthamin yellow (CY), a flavonoid compound extracted from safflower, has been reported to attenuate cardiac ischemia and reperfusion injury. However, whether CY could ameliorate ischemic stroke is not completely understood. In the present study, preventive effects of on experimental were investigated using middle cerebral artery occlusion (MCAO) model rats. Neurological scores, brain edema, infarct area microtubule‑associated protein 2 (MAP‑2) immunoreactivity assessed evaluate The...
To obtain more accurate and rapid predictors of postoperative infections following percutaneous nephrolithotomy (PCNL) in patients with complex kidney stones, provide evidence for early prevention treatment infections.A total 802 stones who underwent PCNL, from September 2016 to 2017, were recruited. Urine tests, urine cultures (UCs) stone (SCs) performed, the perioperative data prospectively recorded.In all, 19 (2.4%) developed urosepsis. A multivariate logistic regression analysis revealed...
Breast cancer (BC) is a highly heterogeneous disease, and although immunotherapy has recently increased patient survival in number of solid hematologic malignancies, most BC subtypes respond poorly to immune checkpoint blockade therapy (ICB). B cells, particularly those that congregate tertiary lymphoid structures (TLS), play significant role antitumour immunity. However, B-cell heterogeneity at single-cell resolution its clinical significance with TLS need be explored further.Primary tumour...
Abstract Gastric cancer is a highly prevalent disease that poses serious threat to public health. In clinical practice, gastroscopy frequently used by medical practitioners screen for gastric cancer. However, the symptoms of at different stages advancement vary significantly, particularly in case early (EGC). The manifestations EGC are often indistinct, leading detection rate less than 10%. recent years, researchers have focused on leveraging deep learning algorithms assist professionals...
Blunt chest injuries are the predominant cause of rib fractures, which frequently result in pulmonary complications. We hypothesized that different trauma mechanisms and fracture patterns associated with complications elderly patients (≥65 years) isolated fractures. retrospectively reviewed data fractures recorded electronic medical record system a center from 2015 to 2019. The correlation between age, comorbidities, mechanisms, patterns, was examined. A total 168 after were included study....
Background Kidney stones are a prevalent disorder that is linked to range of metabolic variables. The cardiometabolic index (CMI) newly developed combined measure used evaluate the state health. Nevertheless, association between CMI and kidney stone remains little investigated. Methods In this study, cross-sectional analysis was done on NHANES data from 2007 2018. prevalence investigated using logistic regression analysis. To look into nonlinear link them, we restricted cubic spline (RCS)...
Apoptosis-stimulating protein of p53-2 (ASPP2) induces apoptosis by promoting the expression pro-apoptotic genes via binding to p53 or p73; however, exact mechanisms which ASPP2 apoptotic death in hepatoma cells are still unclear. Here, we show that transient overexpression autophagic p53- p73-independent C/EBP homologous (CHOP) expression. CHOP decreases Bcl-2; this change releases Beclin-1 from cytoplasmic Bcl-2-Beclin-1 complexes and allows it initiate autophagy. However, can induce...
Abstract Our previous studies have demonstrated that inhibition of glycogen synthase kinase 3 β (GSK3 ) activity protects mice from acute liver failure (ALF), whereas its protective and regulatory mechanism remains elusive. Autophagy is a recently recognized rudimentary cellular response to inflammation injury. The aim the present study was test hypothesis GSK3 mediates autophagy inhibit protect against ALF. In ALF model induced by d -galactosamine ( -GalN) lipopolysaccharide (LPS),...
Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation, the passage of nutrients oxygen, discharge metabolites. In this study, collagen scaffold with axially-aligned luminal conduits was prepared. vitro biocompatibility analysis revealed it enhances activity neural stem cells promotes extension, without affecting differentiation. The loaded improved hindlimb motor function in rat model T8 complete transection promoted...
To evaluate the safety and feasibility of left subclavian artery (LSA) revascularization techniques during thoracic endovascular aortic repair (TEVAR)-the in situ needle fenestration (ISNF) technique carotid-subclavian bypass (CS-Bp)-for complicated pathologies.
This study aimed to compare the outcomes of liver resection for unilateral and bilateral intrahepatic stones.Hepatectomy is effective in treating stones accompanied by biliary stricture or segmental atrophy. The between may be varied because different complexity these 2 subtypes disease.From January 1992 December 2008, 718 consecutive patients with underwent elective hepatectomy our center were reviewed. (n = 461) 257) compared. consistency extent (ELR) stone-affected segments (SAS) was...
Abstract Background The biological phenotype of tumours evolves during neoadjuvant chemotherapy (NAC). Accurate prediction pathological complete response (pCR) to NAC in the early-stage or posttreatment can optimize treatment strategies improve breast-conserving rate. This study aimed develop and validate an autosegmentation-based serial ultrasonography assessment system (SUAS) that incorporated ultrasonographic features throughout breast cancer predict pCR. Methods A total 801 patients with...
Apigenin is the active ingredient in Ludangshen.Although previous studies reported cardioprotective actions of apigenin against doxorubicin (Dox)-induced cardiomyopathy, underlying mechanisms remain incompletely understood.Since beneficially regulates various aspects mitochondrial function and dynamics, we asked whether improves heart mice with Dox-induced cardiomyopathy by regulating unfolded protein response (UPR mt ).Co-administration significantly restored function, reduced myocardial...
Abstract Mendelian randomization (MR) is a powerful tool for causal inference in epidemiology. However, the presence of weak instrumental variables (IVs) and pleiotropy can lead to biased effect estimates. To address these issues, we develop MR-GMM, novel MR method based on Gaussian Mixture Model. MR-GMM classifies IVs into four categories—invalid, valid, invalid&null, null IVs— models their effects using two-dimensional spike-and-slab distribution. Simulation studies demonstrate high...
One of the challenges laparoscopic liver resection (LLR) is exposure surgical field. We propose a new approach to better expose right liver, stretching ligamentum teres hepatis (SLTH), and we evaluated its clinical feasibility limitations through study analyzing relevant cases. Clinicopathologic data on patients who underwent partial hepatectomy (LRPH) at our center were retrospectively collected, subjects 276 with space-occupying lesions met selection criteria (SLTH) or conventional (no...
Background/Objectives: Bone metastasis is a frequent and life-threatening event in advanced cancers, affecting up to 70–85% of prostate cancer patients. Understanding the cellular molecular mechanisms underlying bone essential for developing targeted therapies. This study aimed systematically characterize heterogeneity microenvironmental adaptation metastases using single-cell transcriptomics. Methods: We integrated largest transcriptome dataset date, encompassing 124 samples from primary...
<title>Abstract</title> <bold>Background/Objective: </bold>Circulating metabolites have been found to play an important role in the development of renal cancer, however, specific pathways and mechanisms their influence are still largely unknown. We aimed investigate kidney cancer explain from a genetic perspective. <bold>Method</bold>: explored plasma urinary using two-sample mendelian randomization (MR) separately validated it multiple databases; addition, we performed rigorous tests...
The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated (IMRT) and RapidArc (RA) identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC).Twenty patients with HCC were enrolled in this study. Dosimetric values 3DCRT, IMRT, RA calculated total dose 50 Gy/25 f. percentage normal volume receiving >40, >30, >20, >10, >5 Gy (V(40), V(30), V(20), V(10) V(5)) evaluated...