A5030476226- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Galectins and Cancer Biology
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Viral Infections and Immunology Research
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
Beijing Chao-Yang Hospital
2016-2025
Capital Medical University
2016-2025
Chongqing Cancer Hospital
2024-2025
Chongqing University
2024-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Sichuan Mianyang 404 Hospital
2024
Sun Yat-sen University
2020-2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Shanghai Changzheng Hospital
2024
Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form mucus gel layer overlying gut epithelium. Impaired expression O-glycans has been observed in patients with ulcerative colitis (UC), but its role etiology this disease is unknown. Here, we report mice epithelial cell–specific deficiency core 1–derived O-glycans, predominant developed spontaneous resembled human UC, including massive myeloid infiltrates and crypt abscesses. The manifested...
Peroxisome proliferator-activated receptor α (PPARα) has been reported to induce a potent anti-inflammatory response. Autophagy is recently recognized rudimentary cellular response inflammation and injury. The aim of the present study was test hypothesis that PPARα activation mediates autophagy inhibit liver protect against acute failure (ALF). expression during ALF impact by Wy-14 643 on hepatic immune were studied in D-galactosamine/lipopolysaccharide-induced mouse model. inhibited...
Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent primary malignancies with high heterogeneity in urological system. Growing evidence implies that lactate a significant carbon source for metabolism and plays vital role tumor development, maintenance, therapeutic response. However, global influence lactate-related genes (LRGs) on prognostic significance, microenvironment characteristics, response has not been comprehensively elucidated patients KIRC. In present study, we...
Abstract Background The encapsulation of circular RNAs (circRNAs) into extracellular vesicles (EVs) enables their involvement in intercellular communication and exerts an influence on the malignant advancement various tumors. However, regulatory role EVs-circRNA renal cell carcinoma (RCC) remains elusive. Methods vitro vivo functional experiments were implemented to measure effects circEHD2 phenotype RCC. EVs-circEHD2 activation fibroblasts was assessed by collagen contraction assay, western...
Abstract Acute liver failure (ALF) is a life‐threatening condition that occurs when the sustains severe damage and rapidly loses its function. The primary cause of ALF overdose acetaminophen (APAP), treatment relatively limited. involvement complement system in development has been implicated. However, related mechanisms remain poorly understood. Complement 3 ( C3 ) knockout mice, 3a receptor (C3aR) platelet C‐type lectin‐like 2 Clec‐2 )–deficient myeloid cell podoplanin Pdpn )‐deficient...
Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical implications acute respiratory distress syndrome (ARDS) patients explore histone-mediated effects through ex-vivo investigations. histones, cytokine profiles data from 96 ARDS 30 healthy volunteers obtained. Human bronchial epithelial cells (BEAS-2B), human pulmonary artery endothelial...
Abstract Our previous studies have demonstrated that inhibition of glycogen synthase kinase 3 β (GSK3 ) activity protects mice from acute liver failure (ALF), whereas its protective and regulatory mechanism remains elusive. Autophagy is a recently recognized rudimentary cellular response to inflammation injury. The aim the present study was test hypothesis GSK3 mediates autophagy inhibit protect against ALF. In ALF model induced by d -galactosamine ( -GalN) lipopolysaccharide (LPS),...
// Qian Wang 1 , Lei Yang 3 Xin Hu Yuliang Jiang Yizhang Zhe Liu Jian Tao Wen Yingmin Ma 2 Guangyu An Guosheng Feng Department of Oncology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, 100020, China Respiratory Medicine, Research Center, Correspondence to: Feng, email: fengguoshengcyh@163.com An, anguangyucyh@163.com Ma, mayingmincyh@163.com Keywords: long non-coding RNA, NNT-AS1, colorectal cancer, MAPK/Erk, biomarker Received: April 17, 2016 Accepted: November 21,...
Green vegetables are thought to have a chemoprotective effect on the basis of epidemiologic evidence. This study investigated whether chlorophyllin (CHL) could induce antioxidant enzymes and confer protection against oxidative damage. The results showed that CHL HO-1 NQO1 expression in human umbilical vein endothelial cell (HUVEC) time- dose-dependent manner protect them hydrogen peroxide caused induction by was accompanied with accumulation transcription factor Nrf2 nucleus activation...
Abstract Acute liver failure (ALF) is a life-threatening systemic disorder. Here we investigated the impact of circulating histones, recently identified inflammatory mediators, on inflammation and injury in murine models patients with ALF. We analyzed histone levels blood samples from 62 ALF, 60 chronic disease, 30 healthy volunteers. incubated patients' sera human L02 hepatocytes monocytic U937 cells to assess cellular damage cytokine production. d -galactosamine plus lipopolysaccharide...
Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role NID1 pathogenesis is unclear. In present study, we demonstrated that was mesenchymal associated gene and its high expression significantly correlated with shorter overall survival patients. The ectopic OVCAR-3 cells revealed epithelial-mesenchymal transition (EMT) phenotype accompanied by enhancement motility, invasiveness cisplatin resistance,...
Globally lung cancer is common among males and recently also noted with increasing incidences in females, especially adenocarcinoma. Further, most cancers are not easily detected until the late stage. Metabolic profiling of plasma low molecular weight metabolites may help unveil complex pathophysiological changes during early adenocarcinoma development. Here we used a combination gas chromatography-mass spectrometry (GC-MS) liquid (LC-MS) methods to investigate metabolic signatures 31 stage...
Abstract Background: Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger are unclear. The authors hypothesize extracellular histones, newly identified inflammatory mediator, play important roles pathogenesis of ARDS. Methods: used hydrochloric ARDS model to investigate whether histones pathogenic and targeting protective. Exogenous antihistone antibody were administered mice. Heparin can bind so studied...
microRNAs are aberrantly expressed during the development and progression of a variety human cancers, including colorectal cancer (CRC). Of these microRNAs, microRNA-375 (miR-375) was previously observed to be downregulated in cancer(CRC) plasma tissues, but its functions largely unknown. Here, we investigated impact miR-375 on CRC metastasis. Specifically, expression significantly decreased tissues compared with their matched noncancerous (NCTs), low levels predicted tumor metastatic...
Aberrant O-glycosylation is frequently observed in colorectal cancer (CRC) patients, but it unclear if contributes intrinsically to tumorigenesis. Here, we investigated the biological consequences of aberrant CRC. We first detected expression profile Tn antigen a serial human CRC tissues and then explored genetic biosynthetic mechanisms. Moreover, used cell line (LS174T), which express antigen, assess whether can directly promote oncogenic properties. It showed that was around 86% primary...
Purpose: The aim of this study was to verify the effectiveness and explore mechanism Chaihu-Guizhi-Ganjiang decoction (CGGD) in treatment chronic non-atrophic gastritis (CNAG) with gallbladder heat spleen cold syndrome (GHSC) by metabolomics based on UHPLC-Q-TOF/MS. Patients Methods: An observational controlled before-after conducted CGGD CNAG GHSC from January June 2023, enrolling 27 patients, who took for 28 days. 30 healthy volunteers were enrolled as controls. efficacy evaluated...
Circulating histones are a newly recognized mediator implicated in various inflammatory diseases. It is likely that the release of histones, from dying hepatocytes or leukocytes, into circulation initiates and amplifies inflammation during course acute liver failure (ALF). In this study, we investigated putative pathogenic role circulating murine model ALF induced by D-galactosamine (GalN) plus lipopolysaccharide (LPS). Hepatic function histological indexes, myeloperoxidase (MPO) activity,...
Glycogen synthase kinase 3β(GSK3β) is a ubiquitous serine-threonine protein that participates in numerous cellular processes and disease pathophysiology. We aimed to determine therapeutic potential of GSK3β inhibition its mechanism well-characterized model lipopolysaccharide (LPS)-induced acute liver failure (ALF).In murine ALF induced by D-GalN(700 mg/kg)/LPS(10 µg/kg), we analyzed mechanisms using specific chemical inhibitor, SB216763, detected the role endoplasmic reticulum stress (ERS)....