A5100391001- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cholesterol and Lipid Metabolism
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Mycobacterium research and diagnosis
- Nuclear Receptors and Signaling
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Prenatal Screening and Diagnostics
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Lipid metabolism and disorders
- Spaceflight effects on biology
- Streptococcal Infections and Treatments
- Hepatitis B Virus Studies
- Methemoglobinemia and Tumor Lysis Syndrome
- Advanced Image and Video Retrieval Techniques
- Signaling Pathways in Disease
- Neonatal Health and Biochemistry
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2022-2024
Shanghai Polytechnic University
2024
Southern Medical University
2014-2023
Zhujiang Hospital
2020-2023
University of South China
2023
Nanfang Hospital
2013-2022
XinHua Hospital
2022
Guizhou Provincial People's Hospital
2022
Chengdu University of Traditional Chinese Medicine
2022
Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the initiation and progression hepatocellular carcinoma (HCC), but clinicopathologic significance potential role lncRNA PTTG3P (pituitary tumor-transforming 3, pseudogene) in HCC remains largely unknown.We compared expression profiles lncRNAs 3 tumor tissues adjacent non-tumor by microarrays. In situ hybridization (ISH) quantitative real-time polymerase chain reaction (qRT-PCR) were applied to assess level prognostic...
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The mechanisms underlying ASD are unclear. Astrocyte alterations noted in patients and animal models. However, whether astrocyte dysfunction causal or consequential to ASD-like phenotypes mice unresolved. Type 2 inositol 1,4,5-trisphosphate 6 receptors (IP3R2)-mediated Ca2+ release from intracellular stores results the activation of astrocytes. Mutations IP3R2 gene associated with ASD. Here, we show that both IP3R2-null...
Cardiovascular disease caused by atherosclerosis is the number one cause of death in Western countries and threatens to become major morbidity mortality worldwide. Long noncoding RNAs are emerging as new players gene regulation, but how long operate development remains unclear.Using microarray analysis, we found that RNA RP5-833A20.1 expression was upregulated, whereas nuclear factor IA (NFIA) downregulated human acute monocytic leukemia macrophage-derived foam cells. Moreover, showed may...
Accumulated evidence shows that G protein-coupled receptor 119 (GPR119) plays a key role in glucose and lipid metabolism. Here, we explored the effect of GPR119 on cholesterol metabolism inflammation THP-1 macrophages atherosclerotic plaque progression apoE(-/-) mice. We found oxidized LDL (Ox-LDL) significantly induced long intervening noncoding RNA (lincRNA)-DYNLRB2-2 expression, resulting upregulation ABCA1 expression through glucagon-like peptide 1 signaling pathway. decreased cellular...
Noncoding RNAs are emerging as important players in gene regulation and disease pathogeneses. Here, we show that a previously uncharacterized long noncoding RNA, nexilin F-actin binding protein antisense RNA 1 (NEXN-AS1), modulates the expression of actin-binding NEXN exerts protective role against atherosclerosis. An microarray analysis showed both NEXN-AS1 was reduced human atherosclerotic plaques. In vitro experiments revealed interacted with chromatin remodeler BAZ1A 5' flanking region...
Angiogenesis is considered as an important process in the development of malignancies and associated with cancer progression metastasis. Hepatocellular carcinoma (HCC) most common primary tumor liver recognized a typical angiogenic tumor. Thus, it great importance to study underlying mechanism angiogenesis HCC. The long non-coding RNA (lncRNA) ubiquitin conjugating enzyme E2C pseudogene 3 (UBE2CP3) has been reported oncogene that promotes metastasis However, role mechanisms UBE2CP3 HCC are...
Accumulating evidence supports an important role for the hepatitis B virus x protein (HBx) in pathogenesis of (HBV)-induced hepatocellular carcinoma (HCC), but underlying mechanisms are not entirely clear. Here, we identified a novel long noncoding RNA (lncRNA) DBH-AS1 involved HBx-mediated hepatocarcinogenesis. The levels were positively correlated with surface antigen (HBsAg) and tumor size HCC tissues. Functionally, transgenic expression significantly enhanced cell proliferation...
Current glioma therapies allow in situ delivery of cytotoxic drugs to the tumour; however, gliomas show early recurrence due their highly proliferative character. Long non-coding (lnc)RNAs play critical roles tumorigenesis by controlling cell proliferation and cycling. However, mechanism action lncRNAs development remains unclear. Here, we report that lncRNA PLAC2 induces cycle arrest targeting ribosomal protein (RP)L36 glioma. RPL36 promoted G1/S progression. Mass spectrometry analysis...
Lung cancer is the leading cause of cancer-related deaths in world. Non-small cell lung (NSCLC) accounts for 85% all cases. For lack conveniently sensitive and specific biomarkers, majority patients are late stage at initial diagnosis. Long non-coding RNAs (LncRNAs), a novel type RNA, have recently been recognized as critical factors tumor initiation progression, but role exosomal LncRNAs has not thoroughly excavated NSCLC yet.We isolated exosomes from serum with healthy controls. Exosome...
Abstract Astrocytes are key components of the niche for neural stem cells (NSCs) in adult hippocampus and play a vital role regulating NSC proliferation differentiation. However, exact molecular mechanisms by which astrocytes modulate have not been identified. Here, we identified adenosine 5′-triphosphate (ATP) as proliferative factor required astrocyte-mediated NSCs hippocampus. Our results indicate that ATP is necessary sufficient to promote vitro. The lack inositol 1,4,5-trisphosphate...
// Qian Wang 1 , Lei Yang 3 Xin Hu Yuliang Jiang Yizhang Zhe Liu Jian Tao Wen Yingmin Ma 2 Guangyu An Guosheng Feng Department of Oncology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, 100020, China Respiratory Medicine, Research Center, Correspondence to: Feng, email: fengguoshengcyh@163.com An, anguangyucyh@163.com Ma, mayingmincyh@163.com Keywords: long non-coding RNA, NNT-AS1, colorectal cancer, MAPK/Erk, biomarker Received: April 17, 2016 Accepted: November 21,...
Abstract Atherosclerosis is a chronic inflammatory disease of the arterial intima and becoming leading cause morbidity mortality worldwide. There considerable evidence that defective autophagy overproduction reactive oxygen species (ROS) are closely involved in development progression atherosclerosis. Here, polymer developed with inherent autophagy‐inducing activity to treat atherosclerosis by co‐delivering antioxidant enzymes. The lead material P5c screened from library polypyridiniums...
Aim: High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, scavenger receptor class B type I (SR-BI). Liver X receptors (LXRs) operate as sensors which may protect overload by stimulating to HDL through ABCA1, ABCG1 SR-BI. The regulation of SR-BI expression cytokines present within microenvironment atheroma play an important role in determining impact reverse transport on...
Atherosclerosis is a common pathological basis of cardiovascular disease, which remains the leading cause mortality. Long noncoding RNAs (lncRNAs) are newly studied non-protein-coding involved in gene regulation, but how lncRNAs exert regulatory effect on atherosclerosis unclear. In this study, we found that lncRNA HOXC cluster antisense RNA 1 (HOXC-AS1) and homeobox C6 (HOXC6) were downregulated carotid by performing microarray analysis. The results verified atherosclerotic plaques normal...
Extracellular vesicles (EVs) loaded with proteins, nucleic acids, membrane lipids, and other virulence factors could participate in pathogenic processes some fungi such as Cryptococcus neoformans Candida albicans . However, the specific characteristics of EVs derived from Talaromyces marneffei (TM) still have not been figured out yet. In present study, it has observed that TM-derived were a heterogeneous group nanosized (30–300 nm) under nanoparticle tracking analysis transmission electron...
Exosomes can encapsulate lncRNA to mediate intercellular communication in cancer progression. Our study devoted research the effect that long noncoding RNA Metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) influence on cervical (CC).MALAT1 and miR-370-3p levels CC was assessed using qRT-PCR. CCK-8 assay flow cytometry were confirm MALAT1 influencing proliferation cisplatin-resistant cells. Futher more, MALAT1, combined with confirmed by dual-luciferase reporter...
It is clear that lipid disorder and inflammation are associated with cardiovascular diseases underlying atherosclerosis. Nur77 has been shown to be involved in inflammatory response metabolism.Here, we explored the role of atherosclerotic plaque progression apoE(-/-) mice fed a high-fat/high cholesterol diet.The gene, nuclear hormone receptor, was highly induced by treatment Cytosporone B (Csn-B, specific agonist), recombinant plasmid over-expressing (pcDNA-Nur77), while inhibited siRNAs...
Schematic representing the anti-cancer effects of nano-HAPs both <italic>in vitro</italic> and vivo</italic> by downregulating FAK/PI3K/Akt signaling pathway.