A5100618196- Neuroinflammation and Neurodegeneration Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Estrogen and related hormone effects
- Axon Guidance and Neuronal Signaling
- Olfactory and Sensory Function Studies
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Neurological Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Healthcare and Venom Research
- Monoclonal and Polyclonal Antibodies Research
- Calcium signaling and nucleotide metabolism
- HER2/EGFR in Cancer Research
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Language, Metaphor, and Cognition
- PARP inhibition in cancer therapy
- Reproductive System and Pregnancy
- Histone Deacetylase Inhibitors Research
Wenzhou Medical University
2018-2025
Hangzhou Normal University
2021-2025
École Polytechnique
2024
Nanjing Medical University
2024
Zhejiang Center for Disease Control and Prevention
2022-2024
Capital Medical University
2022-2024
Anhui University of Traditional Chinese Medicine
2020-2024
Kunming Medical University
2022-2024
First Affiliated Hospital of Kunming Medical University
2022-2024
Central South University
2013-2024
Noncoding RNAs are emerging as important players in gene regulation and disease pathogeneses. Here, we show that a previously uncharacterized long noncoding RNA, nexilin F-actin binding protein antisense RNA 1 (NEXN-AS1), modulates the expression of actin-binding NEXN exerts protective role against atherosclerosis. An microarray analysis showed both NEXN-AS1 was reduced human atherosclerotic plaques. In vitro experiments revealed interacted with chromatin remodeler BAZ1A 5' flanking region...
Gliosis is a histopathological characteristic of epilepsy that comprises activated microglia and astrocytes. It unclear whether or how crosstalk occurs between astrocytes in the evolution epilepsy. Here, we report mouse model status epilepticus, induced by intracerebroventricular injection kainic acid (KA), sequential activation their close spatial interaction hippocampal CA3 region. Microglial ablation reduced astrocyte upregulation complement C3. When compared to wild-type mice, both C3
Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo pathway and functions in controlling size of multiple organs, such as liver during development. However, it not clear whether YAP signaling participates process formation glia scars after spinal cord injury (SCI). In this study, we found that was upregulated activated astrocytes C57BL/6 male mice SCI a pathway-dependent manner. Conditional knockout (KO) yap significantly inhibited astrocytic...
Abstract Senescent astrocytes accumulate with aging and contribute to brain dysfunction diseases such as Alzheimer's disease (AD), however, the mechanisms underlying senescence of during remain unclear. In present study, we found that Yes‐associated Protein (YAP) was downregulated inactivated in hippocampal mice AD model mice, well D‐galactose paraquat‐induced senescent astrocytes, a Hippo pathway‐dependent manner. Conditional knockout YAP significantly promoted premature including reduction...
Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes visual disability. Astrocytes are pivotal regulators neuroinflammation MS, and astrocytic yes-associated protein (YAP) plays a critical role neuroinflammation. Meanwhile, YAP signaling involved impairment, including glaucoma, retinal choroidal atrophy detachment. However, the roles underlying mechanisms demyelination MS-related optic (MS-ON) remains unclear. Methods: To assess functions MS-ON,...
The ubiquitous presence of Microplastics (MPs) in various environments documented recent years has recently raised significant concerns about their toxic effects. While macrophages serve as the first line defense against substances and pathogens, impact mechanisms microplastics on these immune cells remain unclear. This study aims to explore whether MPs induce macrophage apoptosis through promotion reactive oxygen species (ROS) generation alterations metabolic profiles. viability RAW264.7...
Estrogen induces G protein-dependent nongenomic signaling in a variety of cell types via the activation plasma membrane-associated subpopulation estrogen receptor alpha (ER alpha). Using pull-down experiments with purified recombinant proteins, we now demonstrate that ER binds directly to i and betagamma. Mutagenesis addition blocking peptide reveals this occurs amino acids 251-260 271-595 alpha, respectively. Studies complexed heterotrimeric proteins further show estradiol causes release...
Neuroinflammation plays a crucial role in the pathogenesis and progression of Alzheimer's disease (AD). The Sterile Alpha Toll Interleukin Receptor Motif-containing protein 1 (SARM1) has been shown to promote axonal degeneration is involved neuroinflammation. However, SARM1 AD remains unclear. In this study, we found that was reduced hippocampal neurons model mice. Interestingly, conditional knockout (CKO) central nervous system (CNS, SARM1<sup>Nestin</sup>-CKO mice) delayed cognitive...
Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for poor prognosis of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic interventions cerebral I/R are still very limited. Melatonin, an endogenous hormone, was found to be valid in preventing a variety organs. However, systematic review covering all neuroprotective effects melatonin has not been reported yet. Thus, we perform comprehensive overview influence on by collecting available...
Ligustilide (LIG), a main lipophilic component isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root), has been shown to alleviate cerebral ischemia injury paly neuroprotective role. We investigated mechanisms underlying the antiapoptotic effects of LIG in vitro vivo, respectively, using cultured primary hippocampal neurons under oxygen-glucose deprivation/reperfusion (OGD/R) rats reperfusion(I/R) conditions. In studies revealed...
Abstract Background The prevalence and characteristics of inappropriate use proton pump inhibitors (PPIs) to prevent stress-related mucosal disease (SRMD) during the perioperative period its associated factors are rarely reported. This study aimed investigate prophylactic identify in a tertiary care academic teaching hospital China provide evidence for regulation authorities pharmacists take targeted measures promote rational drug use. Methods Inpatients who underwent surgical operations...
Abstract Central and systemic inflammation play pivotal roles in epileptogenesis proepileptogenesis temporal lobe epilepsy (TLE). The interplay between peripheral CD4 + T cells central microglia orchestrates the “systemic‐central” immune response TLE. However, precise molecular mechanisms linking TLE remain unknown. This preliminary findings revealed an imbalance Th1/Th2 subsets periphery，accompanied by related cytokines release patients. they proposed that this may influence mediating...
Abstract Objective We aimed to investigate the roles and underlying mechanisms of YAP in proliferation neuroblastoma cells. Methods The expression level was evaluated by Western blotting immunocytochemistry. Cell viability, cell growth were detected CCK‐8, PH3 Ki67 immunostaining, real‐time analyser system. nuclear cytoplasmic proteins p27 Kip1 dissociated nuclear‐cytosol extraction kit mRNA levels Akt, CDK5 CRM1 determined qRT‐PCR. Results enriched SH‐SY5Y cells (a human line). Knock‐down...
Long non-coding RNAs (lncRNAs) play a significant role in pulmonary hypertension (PH). Our preliminary data showed that hypoxia-induced PH is attenuated by fibroblast growth factor 21 (FGF21) administration. Therefore, we further investigated the regulatory of long treated with FGF21. RNA sequencing analysis and real-time PCR identified significantly up-regulation H19 after FGF21 Moreover, gain- loss-of-function assays demonstrated suppressed proliferation artery smooth muscle cells...
Aim We aimed to investigate the differences in clinical features (specifically, patterns of symptoms) COVID-19 patients early and late stage this large scale outbreak Shaanxi Province China based on data from a survey. Methods This study used baseline survey characteristics pandemic province Dec.2022 Jan. 2021. A total 44 sampling clusters (11 villages rural areas 33 residential urban areas) were chosen for enrollment participants. self-developed questionnaire was applied collection. 14,744...
Hydrogen sulfide (H(2)S) is not only one of the main causes halitosis but also an agent toxicity against periodontal cells and tissues in biofilm-related diseases. Also, apoptosis gingival epithelial may play important role onset progress periodontitis. We examined effect H(2)S on induction apoptosis, using human fibroblasts (HGF) keratinocyte-like Ca9-22 derived from gingiva. The were incubated with (100 ng ml(-1)) for 24, 48 or 72 h by adding to air containing 5% CO(2), supplied constantly...