A5100387084- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Sunflower and Safflower Cultivation
- Barrier Structure and Function Studies
- Mitochondrial Function and Pathology
- Phytoestrogen effects and research
- Reproductive System and Pregnancy
- Metabolomics and Mass Spectrometry Studies
- Bone Tumor Diagnosis and Treatments
- Metallurgical Processes and Thermodynamics
- Plant-based Medicinal Research
- GDF15 and Related Biomarkers
- GABA and Rice Research
- Natural product bioactivities and synthesis
- Inflammasome and immune disorders
- Bioactive Compounds in Plants
- Cancer-related molecular mechanisms research
- Pregnancy-related medical research
- Advanced Glycation End Products research
- Sesame and Sesamin Research
- Medicinal plant effects and applications
- Medicinal Plants and Neuroprotection
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
Anhui University of Traditional Chinese Medicine
2008-2024
Affiliated Hospital of Guilin Medical College
2024
Western Sydney University
2018-2019
Ministry of Education of the People's Republic of China
2016-2018
Ligustilide (LIG), a main lipophilic component isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root), has been shown to alleviate cerebral ischemia injury paly neuroprotective role. We investigated mechanisms underlying the antiapoptotic effects of LIG in vitro vivo, respectively, using cultured primary hippocampal neurons under oxygen-glucose deprivation/reperfusion (OGD/R) rats reperfusion(I/R) conditions. In studies revealed...
Neurodegeneration is one of the primary etiologies in onset Parkinson's disease. In quest for a new antiparkinsonism treatment potential benefits puerarin from roots Pueraria lobata have been recognized. Thus, we examined whether capable to protect dopaminergic neurons substantia nigra against 6-hydroxydopamine induced neuronal cell death. Our data showed that intraperitoneal administration 0.12 mg/kg/day over 10 days reduced 6-hydroxydopamine-induced decrease tyrosine hydroxylase-positive...
Abstract: Chuanxiong rhizome has been widely used for the treatment of cerebral vascular disease in traditional Chinese medicine. The integrity blood–brain barrier (BBB) is closely linked to disease. protective effects ligustilide, major bioactive component , on blood vessels have reported previously, but its and potential mechanism BBB not entirely clarified. In current work, ligustilide permeability underlying molecular mechanisms had investigated using model established by coculturing...
Objective: Angiogenesis led by brain microvascular endothelial cells (BMECs) contributes to the remission of injury after ischemia reperfusion. In this study, we investigated effects hydroxysafflor yellow A(HSYA) on angiogenesis BMECs injured OGD/R via SIRT1-HIF-1α-VEGFA signaling pathway. Methods: The model was established in vitro OGD for 2h and reoxygenation 24h. At first, concentrations vascular growth factor (VEGF), Angiopoietin (ang) platelet-derived (PDGF) supernatant were detected...
This study aimed to investigate the effect and mechanism of ligustilide, main active ingredient in Ligusticum wallichii, on mitochondria fission after PC12 cell injury induced by oxygen glucose deprivation/reperfusion(OGD/R). In experiment, an OGD/R model was established vitro, cells were pre-treated with ligustilide for 3 h, then viability detected CCK-8 method. The different concentrations morphology observed under inverted microscope. Transmission electron microscopy used observe...
<title>Abstract</title> <bold>Objective: </bold>Transsacral screws are commonly utilized in clinical settings for addressing vertical instability injuries of the posterior pelvic ring and fragility fractures elderly patients. Nevertheless, potential stenosis bone corridor resulting from dysmorphism upper sacral segment poses challenges insertion S1 through transsacral screw, increasing risk significant complications such as screw misalignment neurovascular injury. The purpose this study was...
To investigate the protective effect of Tongqiao Huoxue Decoction containing cerebrospinal fluid(TQHXD-CSF) on HT22 cells damaged by oxygen-glucose deprivation/reoxygenation(OGD/R) and whether mechanism is related to regulation ASK1/MKK4/JNK signaling pathway. were subjected OGD/R simulate cerebral ischemia-reperfusion injury(CIRI). Then randomly divided into five groups: blank fluid(control group), group, TQHXD-CSF Z-VAD-FMK group(20 μmol·L~(-1)) TQHXD-CSF+Z-VAD-FMK group. Except control in...
The aim of this study was to evaluate the protective effects Er Miao San (EMS) and regulative function bone marrow-derived dendritic cells (BMDCs) on adjuvant arthritis (AA) in rats.
Mitochondrion, as the main energy-supply organelle, is key target region that determines neuronal survival and death during ischemia. When an ischemic stroke occurs, timely removal of damaged mitochondria very important for improving mitochondrial function repairing nerve damage. This study investigated effect ligustilide(LIG), active ingredient Chinese medicine, on mitophagy based oxygen glucose deprivation/reperfusion(OGD/R)-induced injury model in HT22 cells. By OGD/R-induced was induced...