A5100343948- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Advanced Nanomaterials in Catalysis
- Dendrimers and Hyperbranched Polymers
- Supramolecular Self-Assembly in Materials
- Magnetism in coordination complexes
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Conducting polymers and applications
- Photodynamic Therapy Research Studies
- Magnesium Alloys: Properties and Applications
- Advanced Surface Polishing Techniques
- biodegradable polymer synthesis and properties
- Biosensors and Analytical Detection
- GDF15 and Related Biomarkers
- Advancements in Battery Materials
- Electrochemical sensors and biosensors
- Catalytic C–H Functionalization Methods
Central South University
2022-2025
Liaocheng University
2022-2025
Shandong Provincial Hospital
2022-2025
Tianjin University
2021-2025
Xiangya Hospital Central South University
2022-2025
Qingdao University
2021-2025
Affiliated Hospital of Qingdao University
2021-2025
Wenzhou Medical University
2025
Ruian People's Hospital
2025
Chinese Academy of Sciences
2015-2024
Graphene exhibits unique 2-D structure and exceptional phyiscal chemical properties that lead to many potential applications.Among various applications, biomedical applications of graphene have attracted ever-increasing interests over the last three years.In this review, we present an overview current advances in biomedicine with focus on drug delivery, cancer therapy biological imaging, together a brief discussion challenges perspectives for future research field.
A novel gene delivery system based on graphene oxide chemically-functionalized with branched polyethylenimine (PEI-GO) is reported. The PEI-GO conjugate was formed by the covalent linking of PEI and GO via an amide bond widely used EDC chemistry. Thus-prepared exhibits excellent ability to condense DNA at a low mass ratio positive potential 49 mV. WST assay reveals that significantly less cytotoxic than 25 kDa. Finally, transfection efficiency evaluated. It demonstrated luciferase expression...
Abstract The last few years have witnessed rapid development of biological and medical applications graphene oxide (GO), such as drug/gene delivery, biosensing, bioimaging. However, little is known about the cellular uptake mechanism pathway GO. In this work, surface‐enhanced Raman scattering (SERS) spectroscopy employed to investigate internalization GO loaded with Au nanoparticles (NPs) by Ca Ski cells. presence NPs on surface enables detection enhanced intrinsic signals inside cell. SERS...
Abstract Currently, although conducting polymers have exhibited potential electrophysiological modulation, designing bioinspired ultra‐histocompatible remains a long‐standing challenge. Moreover, the water dispersibility, conductivity, and biocompatibility of are incompatible, which restricts their application in tissue engineering. Herein, multilevel template dispersion strategy is presented to produce poly(3,4‐ethylenedioxythiophene):(dextran sulfate/carboxymethyl chitosan)...
Abstract Conductive hydrogels have shown significant potential in the realm of flexible electronics; however, using water as a solvent introduces problems such low‐temperature freezing and loss. One possible solution to address these limitations is replacing with deep eutectic solvents (DES). In this study, PHEAA–gelatin–MXene (PGM) eutectogels are constructed poly( N ‐hydroxyethyl acrylamide) (PHEAA) gelatin main components, MXene nanosheets added nanofillers. The PGM exhibit exceptional...
Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies...
A positively charged porous drug carrier MOF-74-Fe(III) (1, MOF = metal–organic framework), which could not be directly synthesized using ferric salts, was prepared through the oxidation of neutral crystal MOF-74-Fe(II). This cationic host material exhibits very low cytotoxicity upon PC12 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay and high loading capacity ibuprofen anions (∼15.9 wt %) ion exchange salt penetration procedures. Controlled anion exchange, two...
Delivery of proteins into cells may alter cellular functions as various are involved in signaling by activating or deactivating the corresponding pathways and, therefore, can be used cancer therapy. In this study, we have demonstrated for first time that PEGylated graphene oxide (GO) exploited a nanovector efficient delivery cells. approach, GO was functionalized with amine-terminated 6-armed polyethylene glycol (PEG) molecules, thereby providing proper physiological stability and...
This is high demand to enhance the accumulation of near-infrared theranostic agents in tumor region, which favorable effective phototherapy. Compared with indocyanine green (a clinically applied dye), IR-780 iodide possesses higher and more stable fluorescence intensity can be utilized as an imaging-guided PTT agent laser irradiation. However, lipophilicity short circulation time limit its applications cancer imaging therapy. Moreover, solid lipid nanoparticles (SLNs) conjugated c(RGDyK) was...
Primary hepatocyte culture is a valuable tool that has been extensively used in basic research of liver function, disease, pathophysiology, pharmacology and other related subjects. The method based on two-step collagenase perfusion for isolation intact hepatocytes was first introduced by Berry Friend 1969 1 and, since then, undergone many modifications. most commonly technique described Seglenin 1976 2. Essentially, are dissociated from anesthetized adult rats non-recirculating through the...
Single stranded ribonucleic acid (ssRNA) acts as a probe, antisense (AS), miRNA analog and inhibitor, is promising for gene therapy molecular diagnosis. However, free ssRNA exhibits poor cellular uptake due to its negative charges, enzyme instability, which have largely limited the practical applications of in biomedicine. To address these issues, we developed PEGylated reduced graphene oxide (PEG-RGO) nanovector efficient delivery ssRNA. We demonstrated that PEG-RGO superior loading...
Abstract The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo in mice was induced by an liquid diet vitro studies were performed on activated HSC-T6 LX2 cells treated with lipopolysaccharide. Our results showed that significantly attenuated hepatic stellate (HSCs) activation, improved collagen accumulation inflammation through down-regulating levels myeloid differentiation factor 88 (MyD88), nuclear κB...
Hybridization is emerged as a promising strategy in the discovery of new drugs, especially these with complimentary activities and multiple pharmacological targets that are potential weapons to prevent drug resistance. Currently, several hybrids under different stages clinical trial, may be introduced into practice treat various diseases near future. Triazoles including 1,2,3‐triazole 1,2,4‐triazole well coumarins occupy an important position medicinal chemistry attribute their biological...
A novel gadolinium–porphyrin metal–organic framework (MOF) nanosheet was synthesized by coordination chelation between gadolinium(III) ions and 4,4,4,4-(porphine-5,10,15,20-tetrayl) tetrakis (benzoic acid) (TCPP). The mechanism molecular structure of the prepared Gd-TCPP products were analyzed through comparison (benzenesulfonic (TPPS) TCPP. MOF nanosheets exhibit a high relaxation rate 40.8 mM–1 s–1, which is better than rates for most reported contrast agents. In addition, photosensitive...