A5048667139- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced Biosensing Techniques and Applications
- Bacteriophages and microbial interactions
- Mesoporous Materials and Catalysis
- Gene expression and cancer classification
- Nanoplatforms for cancer theranostics
- Molecular Biology Techniques and Applications
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Extracellular vesicles in disease
- Zeolite Catalysis and Synthesis
- Advanced Nanomaterials in Catalysis
- Catalytic Processes in Materials Science
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- DNA and Nucleic Acid Chemistry
- Nanomaterials for catalytic reactions
- RNA and protein synthesis mechanisms
- Graphene and Nanomaterials Applications
Southeast University
2016-2025
Hunan University of Technology
2016-2025
State Key Laboratory of Digital Medical Engineering
2016-2025
Fudan University
2024
Yiwu Science and Technology Research Institute
2024
Southeast University
1998-2022
Hunan University
2021
Tibetan Traditional Medical College
2020
Guangxi Medical University
2019-2020
Nanjing University of Science and Technology
2019
Abstract Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of microenvironment. However, it remains a major problem to detect cancer‐specific due technical biological challenges. Most methods reported could not achieve efficient detection tumor‐derived in background normal exosomes. Herein, label‐free electrochemical aptasensor is presented for specific This platform contains an anti‐CD63 antibody modified...
Exosomes are membrane nanovesicles carrying molecular information that may reflect the biological and genetic characteristics of their parent cells.
A sandwich nanomedicine self-assembled by GO nanosheets and BNN6 exhibits high drug loading capacity NIR responsiveness for NO release.
Aptamers are short single-stranded DNA or RNA oligonucleotides and can be selected from synthetic combinatorial libraries in vitro. They have a high binding affinity specificity for their targets. Agarose gels, nitrocellulose membranes, adsorptive microplates often used as carriers to immobilize targets the SELEX (systematic evolution of ligands by exponential enrichment) process, but subsequent separation step is tedious time-consuming. Therefore, we magnetic nanoparticles (MNPs) target,...
Although gold nanorods (GNRs) have been prepared with a wide range of methods for their uses as novel diagnostic and therapeutic agents, the synthesis monodispersed GNRs high yields size tunability still requires further improvements. We report on simple one-pot method preparing highly using phenols (e.g., hydroquinone, 1,2,3-trihydroxybenzene, 1,2,4-trihydroxybenzene) reducing agent NaBH4 initiating reactant. Fine-tuning LSPR peak position phenols-reduced from 550 to 1150 nm is accomplished...
Abstract Background The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival human tumorigenesis, including gastric cancer. PIK3CA mutations amplification are two major causes of overactivation this cancers. However, until work, there was no sound investigation on the association with clinical outcome cancer, particularly latter. Methods Using direct sequencing real-time quantitative PCR, we examined amplification, their clinicopathological...
Exosomes have been recognized as promising sources of biomarkers for early cancer diagnosis due to their important role in the occurrence and metastasis cancer, so development a sensitive low-cost detection method exosomes is highly desirable. In this paper, we report fluorescence competitive based on an aptamer specific CD63 (an exosome transmembrane protein). Aptamer-modified magnetic beads were hybridized with Cy3-labeled short sequence complementary region aptamer. presence exosomes,...
The failure of adult hippocampal neurogenesis is increasingly considered as an important factor in the pathological correlates for memory decline Alzheimer's disease (AD). Loss adult-born neurons and abnormalities neural stem/progenitor cells (NSPCs) within dentate gyrus (DG) hippocampus might contribute to this process. In study, we showed that amyloid-β1–42 (Aβ42) oligomer triggers senescent phenotype NSPCs vitro. Oligomerized Aβ42 induced production senescence-associated biomarkers p16...
Metallic nanostructures as excellent candidates for nanosensitizers have shown enormous potentials in cancer radiotherapy and photothermal therapy. Clinically, a relatively low safe radiation dose is highly desired to avoid damage normal tissues. Therefore, the synergistic effect of low-dosed X-ray other therapeutic approaches (or so-called "combined strategy") needed. Herein, we synthesized hollow spike-like gold by facile galvanic replacement reaction. Such nanospikes (GNSs) with...