A5100330449- Protein Interaction Studies and Fluorescence Analysis
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Carbon and Quantum Dots Applications
- Quantum Dots Synthesis And Properties
- thermodynamics and calorimetric analyses
- Molecular Sensors and Ion Detection
- Advanced Nanomaterials in Catalysis
- Mitochondrial Function and Pathology
- Advanced Photocatalysis Techniques
- Drug Transport and Resistance Mechanisms
- Electrocatalysts for Energy Conversion
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Electrochemical Analysis and Applications
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Surfactants and Colloidal Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrochemical sensors and biosensors
- Metal complexes synthesis and properties
- Graphene and Nanomaterials Applications
- Photochemistry and Electron Transfer Studies
Wuhan University
2016-2025
Zhejiang University
2022-2025
Tiangong University
2020-2025
Chongqing University
2019-2025
North China Electric Power University
2020-2025
University of Shanghai for Science and Technology
2015-2025
Huazhong Agricultural University
2003-2025
Henan University
2022-2025
Peking University
2006-2025
Shanxi Medical University
2023-2025
Abstract Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health 1–3 . Despite intense research efforts, how, when where new diseases appear are still source of considerable uncertainty. A disease was recently reported in Wuhan, Hubei province, China. As 25 January 2020, at least 1,975 cases had been since the first patient hospitalized on 12 December 2019. Epidemiological investigations have suggested...
The rapid development of proteomics studies has resulted in large volumes experimental data. emergence big data platform provides the opportunity to handle these amounts integrated proteome resource, iProX (https://www.iprox.cn), which was initiated 2017, been greatly improved with an up-to-date implemented 2021. Here, we describe main developments since its first publication Nucleic Acids Research 2019. First, a hyper-converged architecture high scalability supports submission process. A...
Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel experimental inflammatory and neuropathic pain. We report here the discovery A-803467, a blocker potently blocks currents (IC(50) = 140 nM) generation spontaneous electrically evoked potentials vitro rat dorsal root ganglion In recombinant cell lines, A-803467 blocked human 8 was >100-fold...
Metal-organic frameworks (MOFs) have attracted tremendous interest due to their promising applications including electrocatalysis originating from unique structural features. However, it remains a challenge directly use MOFs for oxygen because is quite difficult manipulate dimension, composition, and morphology of the with abundant active sites. Here, facile ambient temperature synthesis NiCoFe-based trimetallic MOF nanostructures foam-like architecture reported, which exhibit extraordinary...
Pd has been the focus of recent research for Pt-alternative catalysts oxygen reduction reaction (ORR). It found that upon appropriate modification its electronic structure, catalytic activity can become comparable to Pt. However, structure-activity relationships have hitherto not well studied or understood. In present work, we report a new finding there is strong dependence toward ORR on morphology. By simply adjusting precursor concentration in electrochemical deposition Pd, are able tailor...
Berberine is an important traditional medicinal herb, which has been effectively used in the treatment of dysentery, diarrhea, stomatitis, throat infections, and hepatitis folk medicine. In this study, interaction between human serum albumin (HSA) was investigated by fluorescence spectroscopy UV-vis absorbance spectroscopy. mechanism discussion, it proved that quenching HSA berberine a result formation berberine-HSA complex. Fluorescence constants were determined using Stern-Volmer equation...
Abstract Replacing sluggish oxygen evolution reaction (OER) with hydrazine oxidation (HzOR) to produce hydrogen has been considered as a more energy-efficient strategy than water splitting. However, the relatively high cell voltage in two-electrode system and required external electric power hinder its scalable applications, especially mobile devices. Herein, we report bifunctional P, W co-doped Co 3 N nanowire array electrode remarkable catalytic activity towards both HzOR (−55 mV at 10 mA...
Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side...
Dumbbell-like Pt(x)Pd(100-x)-Fe(3)O(4) nanoparticles (NPs) were synthesized and studied for electrocatalytic reduction sensing of H(2)O(2). In 0.1 M phosphate buffered saline (PBS) solution, the 4-10 nm NPs showed Pt/Pd composition-dependent catalysis with Pt(48)Pd(52)-Fe(3)O(4) having best activity. The tested H(2)O(2) detection, their detection limit reached 5 nM, which was suitable monitoring generated from Raw 264.7 cells. These dumbbell-like PtPd-Fe(3)O(4) are most sensitive probe ever...
Hydrazone derivatives possess potential antitumor activities based on modulation of the iron metabolism in cancer cell. A novel hydrazone, N′-(2,4-dimethoxybenzylidene)-2-hydroxybenzohydrazide (DBH), has been synthesized and characterized, which is an analogue 311 possessing potent anticancer activity. The interactions between DBH bovine serum albumin (BSA) have investigated systematically by fluorescence, molecular docking, circular dichroism (CD), UV−vis absorption, electrochemical...
Monodisperse CoPd nanoparticles (NPs) were synthesized and studied for catalytic formic acid (HCOOH) oxidation (FAO). The NPs prepared by coreduction of Co(acac)(2) (acac = acetylacetonate) PdBr(2) at 260 °C in oleylamine trioctylphosphine, their sizes (5-12 nm) compositions (Co(10)Pd(90) to Co(60)Pd(40)) controlled heating ramp rate, metal salt concentration, or molar ratios. 8 nm activated HCOOH a simple ethanol wash. In 0.1 M HClO(4) 2 solution, activities followed the trend Co(50)Pd(50)...
Gaseous signaling molecules such as hydrogen sulfide (H2S) are produced endogenously and mediate effects through diverse mechanisms. H2S is one gasotransmitters that regulates multiple pathways in mammalian cells, abnormal metabolism has been linked to defects bone homeostasis. Here, we demonstrate marrow mesenchymal stem cells (BMMSCs) produce order regulate their self-renewal osteogenic differentiation, deficiency results BMMSC differentiation. causes aberrant intracellular Ca(2+) influx...
Abstract Purpose: KRAS-mutant lung cancers have been recalcitrant to treatments including those targeting the MAPK pathway. Covalent inhibitors of KRAS p.G12C allele allow for direct and specific inhibition mutant in cancer cells. However, as other targeted therapies, therapeutic potential these can be impaired by intrinsic resistance mechanisms. Therefore, combination strategies are likely needed improve efficacy. Experimental Design: To identify maximally leverage we defined response a...