A5060032896- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Vision and Imaging
- Diet, Metabolism, and Disease
- Remote Sensing and LiDAR Applications
- Lipid metabolism and biosynthesis
- Mesenchymal stem cell research
- Advanced Photocatalysis Techniques
- Cardiac Fibrosis and Remodeling
- Endoplasmic Reticulum Stress and Disease
- Signaling Pathways in Disease
- Cardiomyopathy and Myosin Studies
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
- Advanced Image and Video Retrieval Techniques
- Coal and Its By-products
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Cardiovascular Disease and Adiposity
Air Force Medical University
2016-2025
Xijing Hospital
2016-2025
Nanjing University of Posts and Telecommunications
2023-2025
Beijing Ditan Hospital
2021-2024
Capital Medical University
2022-2024
Nanjing Normal University
2022-2024
Simon Fraser University
2019-2024
Guizhou Provincial People's Hospital
2023
Dalian Maritime University
2022
Peking University
2020-2021
Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still incompletely understood. Although traditionally considered a thermogenic tissue, brown adipose tissue (BAT) communicates with remote organs (eg, the heart) through its endocrine function. BAT expands in response to exercise, but involvement remains undefined. Objective: This study investigated whether small extracellular vesicles (sEVs) secreted by and their contained microRNAs (miRNAs) regulate...
Cardiac metabolic remodeling is a central event during heart failure (HF) development following myocardial infarction (MI). It well known that glucose and fatty acid dysmetabolism contribute to post-MI cardiac dysfunction remodeling. However, the role of amino metabolism in HF remains elusive. Branched chain acids (BCAAs) are an important group essential function as crucial nutrient signaling mammalian animals. The present study aimed determine BCAA progression. Utilizing coronary artery...
The Western meat-rich diet is both high in protein and fat. Although the hazardous effect of a fat (HFD) upon liver structure function well recognized, whether co-presence intake contributes to, or protects against, HF-induced hepatic injury remains unclear. Increased branched chain amino acids (BCAA, essential compromising 20% total intake) reduces body weight. However, elevated circulating BCAA associated with non-alcoholic fatty disease injury. mechanisms responsible for this quandary...
Either insufficient or excessive autophagy causes cellular death and contributes to myocardial ischaemia/reperfusion (I/R) injury. However, mechanisms controlling the 'right-level' of in heart remains unidentified. Thioredoxin-interacting protein (TXNIP) is a pro-oxidative molecule knowing contribute I/R whether how TXNIP may further inhibit suppressed promote cardiac has not been previously investigated.Wild type gene-manipulated adult male mice were subjected I/R. was increased myocardium...
Rationale: Myocardial vulnerability to ischemia/reperfusion (I/R) injury is strictly regulated by energy substrate metabolism. Branched chain amino acids (BCAA), consisting of valine, leucine and isoleucine, are a group essential that highly oxidized in the heart. Elevated levels BCAA have been implicated development cardiovascular diseases; however, role I/R process not fully understood. The present study aims determine how influence myocardial metabolism further clarify pathophysiological...
Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease. However, whether BCAAs disrupt homeostasis hepatic glucose lipid metabolism remains unknown. In this study, we observed that supplementation significantly reduced high-fat (HF) diet–induced accumulation while increasing plasma levels promoting muscular renal accumulation. Further studies demonstrated increased...
Mesenchymal stromal cell-based therapy is promising against ischemic heart failure. However, its efficacy limited due to low cell retention and poor paracrine function. A transmembrane protein capable of enhancing cell-cell adhesion, N-cadherin garnered attention in the field stem biology only recently.The current study investigates whether how may regulate mesenchymal cells cardioprotective capability failure.Adult mice-derived adipose tissue-derived (ADSC) were transfected with adenovirus...
This paper introduces MVDiffusion, a simple yet effective method for generating consistent multi-view images from text prompts given pixel-to-pixel correspondences (e.g., perspective crops panorama or depth maps and poses). Unlike prior methods that rely on iterative image warping inpainting, MVDiffusion simultaneously generates all with global awareness, effectively addressing the prevalent error accumulation issue. At its core, processes in parallel pre-trained text-to-image diffusion...
Nanoporous structures facilitate the exposure of active sites and allow a high ratio space charge region to bulk in water-splitting photoelectrodes. However, unfavorable surface defects may develop on nanoporous photoelectrodes, which deteriorate band bending (built-in electric field) trigger serious carrier recombination. To maximize advantages one common strategy is introduction ultrathin overlayers passivate undesirable traps, usually require advanced deposition technologies such as...
Sphingosine 1-phosphate (S1P) mediates multiple pathophysiological effects in the cardiovascular system. However, role of S1P signaling pathological cardiac remodeling following myocardial infarction (MI) remains controversial. In this study, we found that greatly increased post-MI, accompanied with a significant upregulation sphingosine kinase-1 (SphK1) and receptor 1 (S1PR1) expression. MI-operated mice, inhibition production by using PF543 (the SphK1 inhibitor) ameliorated dysfunction....
This paper proposes a novel message passing neural (MPN) architecture Conv-MPN, which reconstructs an outdoor building as planar graph from single RGB image. Conv-MPN is specifically designed for cases where nodes of have explicit spatial embedding. In our problem, correspond to edges in different MPN that 1) the feature associated with node represented volume instead 1D vector; and 2) convolutions encode messages fully connected layers. learns select true subset (i.e., edges) reconstruct...
Abstract Few intravenously administered mesenchymal stromal cells (MSCs) engraft to the injured myocardium, thereby limiting their therapeutic efficacy for treatment of ischemic heart injury. Here, it is found that irisin pretreatment increases cardiac homing adipose tissue‐derived MSCs (ADSCs) by single and multiple intravenous injections mice with MI/R more than fivefold, which subsequently antiapoptotic, proangiogenic, antifibrotic effects in rats underwent MI/R. RNA sequencing, Kyoto...
Abstract Mesenchymal stem cells (MSCs) delivered into the post-ischemic heart milieu have a low survival and retention rate, thus restricting cardioreparative efficacy of MSC-based therapy. Chronic ischemia results in metabolic reprogramming heart, but little is known about how these changes influence implanted MSCs. Here, we found that excessive branched-chain amino acid (BCAA) accumulation, signature seen was disadvantageous to cardioprotection intramyocardially injected Discovery-driven...
Abstract Mesenchymal stromal cell (MSC) implantation is a promising option for liver repair, but their poor retention in the injured milieu critically blunts therapeutic effects. The aim to clarify mechanisms underlying massive MSC loss post‐implantation and establish corresponding improvement strategies. primarily occurs within initial hours after into or under reactive oxygen species (ROS) stress. Surprisingly, ferroptosis identified as culprit rapid depletion. In ferroptosis‐...
BACKGROUND: Myocardial mitochondrial dysfunction underpins the pathogenesis of heart failure (HF), yet therapeutic options to restore myocardial function are scarce. Epigenetic modifications DNA (mtDNA), such as methylation, play a pivotal role in modulating homeostasis. However, their involvement HF remains unclear. METHODS: Experimental models were established through continuous angiotensin II and phenylephrine (AngII/PE) infusion or prolonged ischemia/reperfusion injury. The landscape N 6...
Oily sludge is a hazardous waste containing emulsified petroleum hydrocarbons, water, heavy metals, and solid particles. The objective of this work to employ solidification/stabilization (S/S) techniques utilize oily as roadbed material with ordinary Portland cement (OPC), fly ash (FA), silica fume (SF) binders phosphogypsum (PG) stabilizer. efficacy the S/S process assessed mainly through an unconfined compressive strength (UCS) test toxicity leaching test. Road performance, including water...
The farnesoid X receptor (FXR) is a member of the metabolic nuclear superfamily that plays critical regulatory role in cardiovascular physiology/pathology. However, systemic FXR activation chronic phase myocardial infarction (MI)-induced cardiac remodelling and dysfunction remains unclear. In this study, we aimed to elucidate long-term on post-MI dysfunction.Mice underwent either MI surgery or sham operation. At 1 week after MI, both mice were gavaged with 25 mg/kg/d synthetic agonist...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
Stem cell therapy is a potentially effective and promising treatment for ischemic heart disease. Resistin, type of adipokine, has been found to bind adipose-derived mesenchymal stem cells (ADSCs). However, the effects resistin on cardiac homing by ADSCs ADSC-mediated cardioprotective have not investigated. were obtained from enhanced green fluorescent protein transgenic mice. C57BL/6J mice subjected myocardial ischemia-reperfusion (I/R) or sham operations. Six hours after I/R operation,...