A5100448541- Sirtuins and Resveratrol in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- GDF15 and Related Biomarkers
- Drug Transport and Resistance Mechanisms
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Heme Oxygenase-1 and Carbon Monoxide
- Ocular Oncology and Treatments
- Macrophage Migration Inhibitory Factor
- Tea Polyphenols and Effects
- Ferroptosis and cancer prognosis
- Peripheral Neuropathies and Disorders
- Antifungal resistance and susceptibility
- Nitric Oxide and Endothelin Effects
- Cholesterol and Lipid Metabolism
- Cancer-related molecular mechanisms research
- Genetic and rare skin diseases.
- Endoplasmic Reticulum Stress and Disease
- Axon Guidance and Neuronal Signaling
Air Force Medical University
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Zhongnan Hospital of Wuhan University
2021
Wuhan University
2021
Baogang Group (China)
2017
University of California, Davis
2015
World Wide Web Consortium
2010
Abstract Tumor adaptive resistance to therapeutic radiation remains a barrier for further improvement of local cancer control. SIRT3, member the sirtuin family NAD+-dependent protein deacetylases in mitochondria, promotes metabolic homeostasis through regulation mitochondrial deacetylation and plays key role prevention cell aging. Here, we demonstrate that SIRT3 expression is induced an array radiation-treated human tumor cells their corresponding xenograft tumors, including colon HCT-116,...
Sirtuin 5 (SIRT5) is a member of the NAD+‑dependent class III protein deacetylases. Although it known that SIRT5 deacetylates and activates urate oxidase in liver mitochondria mice, mechanism proliferation hepatocellular carcinoma (HCC) remains to be fully elucidated. The present study investigated expression functional significance HCC, examined relevant mechanism. was found upregulated HCC tissues cell lines, higher indicated poorer overall survival. Reverse transcription‑quantitative...
Abstract Glycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts into one-carbon units. GLDC commonly up-regulated and plays important roles in many human cancers. Whether how regulated by post-translational modifications unknown. Here we report mechanistic target rapamycin complex 1 (mTORC1) signal inhibits acetylation at lysine (K) 514 inducing transcription the deacetylase sirtuin 3 (SIRT3). Upon inhibition mTORC1, acetyltransferase acetyl-CoA (ACAT1)...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
Background The dorsal root ganglia (DRG) neuron is an invaluable tool in axon growth, growth factor regulation, myelin formation and myelin-relevant researches. purification of DRG neurons a key step these studies. Traditionally, purified were obtained two weeks after exposure to several rounds anti-mitotic reagent. Methods Results In this report, novel, simple efficient method for presented. cultures treated once with high-dose reagent cocktail 72 hours. Using new method, 99% within 1 week....
Paraquat (PQ) is a widely used agro-chemical in agriculture and highly toxic to humans. Although the mechanism of PQ poisoning not clear, it has been well documented that reactive oxygen species (ROS) generation apoptosis play pivotal roles. Alternatively, chlorogenic acid (CA) biologically active dietary polyphenol, playing several therapeutic However, known whether CA protective effect on PQ-induced apoptosis. Here, we investigated preventing explored underlying mechanisms. A549 cells were...
BACKGROUND Colonic motility dysfunction is a common symptom of ulcerative colitis (UC), significantly affecting patients’ quality life. Evidence suggests that glial cell line-derived neurotrophic factor (GDNF) plays role in restoring colonic function. AIM To investigate whether GDNF enhances aberrant mice with experimental via connexin 43 (Cx43). METHODS An model was induced male C57BL/6 using dextran sodium sulfate (DSS). The measurement transit time conducted, and colon tissues were...
Ferroptosis, an iron-dependent regulated cell death pathway, shares several features of Parkinson's disease (PD) physiopathology, and efficient neuroprotective therapies are required to prevent DAergic neuron initiated by ferroptosis. Electroacupuncture (EA), a treasure Traditional Chinese Medicine, exerted therapeutic effects against PD avoid the side dopamine (DA)-based therapies. However, its underlying mechanisms still need be fully understood. MPTP-induced mice were treated with EA...
Abnormalities in hippocampal synaptic plasticity contribute to the pathogenesis of post-traumatic stress disorder (PTSD). The Wnt/β-catenin signaling pathway is critical for regulation plasticity. PTSD symptoms can be alleviated by correcting impaired neural hippocampus (Hipp). Electroacupuncture (EA) has a therapeutic effect relieving PTSD-like behaviors. However, little known about whether involved EA-mediated improvements symptoms. In this study, we found that enhanced single prolonged...
Myasthenia gravis (MG) is an autoimmune disease mediated by B cells secreting autoantibodies. Regulatory (Breg) confirmed to have immunosuppressive function play important role in many diseases. However, what about the changes Breg thymus and peripheral blood of MG patients? The proportion 41 patients without any drug treatment 30 healthy controls were detected flow cytometry. We found that proportions CD19+ IL-10+ CD19+CD24hiCD38hi cell subsets significantly lower than those controls. Then,...
Abstract Background The stroke induced by ischemia of brain remains high incidence and death rate. study wanted to confirm the effects Quaking 6 (QKI 6) on protection role in neurons rat model cerebral ischemia/reperfusion injury (CIRI). Material methods with CIRI middle artery occlusion was well established were isolated characterize QKI mediated sirtuin 1 (SIRT1) synthesis triglyceride neuron neuronal apoptosis via activation SIRT1‐peroxisome proliferater‐activated receptor (PPAR)γ‐...
Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability the microvascular endothelium is implicated in progression ALI, but processing interaction time course activity vascular regulators exudation are still not understood. The main aim this study was to investigate potential role for endothelial growth factor (VEGF), its receptors, some function related increased phosgene. Sprague Dawley rats were randomly divided into seven groups...
Abstract The response to hyperosmotic stresses in the abdominal cavity is regulated, part, by vasopressin (VP)‐secreting neurons supraoptic nucleus (SON). How osmotic stress signals are transmitted brain incompletely understood, and whether transmission routes for differ between acute chronic unknown. Here we investigated role of vagus, splanchnic nerves, astrocytes SON transducing hyperosmotic‐stress from cavity. We found that administration saline triggered activation as well adjoining...
Abstract The stroke induced by ischemia of brain remains high incidence and death rate. study wanted to confirm the effects QKI 6 on protection role in neurons rat model cerebral ischemia/reperfusion injury (CIRI). with CIRI MCAO (middle artery occlusion) was well established were isolated characterize mediated SIRT1 synthesis triglyceride neuron neuronal apoptosis via activation SIRT1-PPARγ-PGC-1α signaling pathway. expression levels or 6, acetylation level decreased CIRI. deacetylated that...