A5023118874- Cancer Cells and Metastasis
- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Glutathione Transferases and Polymorphisms
- NF-κB Signaling Pathways
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Protein Tyrosine Phosphatases
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Redox biology and oxidative stress
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
University of California, Davis
2015-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
West China Hospital of Sichuan University
2015-2025
Sichuan University
2015-2025
Sun Yat-sen University
2012-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2012-2025
Boai Hospital of Zhongshan
2025
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
Second Hospital of Anhui Medical University
2024
Abstract Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) immune checkpoint CD47 is dominant in recurrent GBM patients poor prognosis. A glycolysis-to-FAO metabolic rewiring associated anti-phagocytosis radioresistant cells regrown radiation syngeneic mice. Inhibition FAO by CPT1 inhibitor etomoxir or...
Activator protein-1 (AP-1) is a transcription factor that consists of either Jun-Jun homodimer or Jun-Fos heterodimer. Transactivation AP-1 required for tumor promoter-induced transformation in mouse epidermal JB6 cells and progression human keratinocytes. Until now, the question whether transactivation carcinogenesis vivo has remained unanswered, as issue functionally significant target genes. To address these issues we have generated transgenic which mutant c-jun (TAM67), under control...
Antioxidant enzymes are critical in oxidative stress responses. Radioresistant variants isolated from MCF-7 human carcinoma cells following fractionated ionizing radiation (MCF+FIR cells) or overexpression of manganese superoxide dismutase (MCF+SOD demonstrated dose-modifying factors at 10% isosurvival 1.8 and 2.3, respectively. MCF+FIR (exposed to single-dose radiation) 5- 10-fold increases MnSOD activity, mRNA, immunoreactive protein. Radioresistance MCF+SOD was reduced expression...
Anthocyanins are the chemical components that give intense color to many fruits and vegetables, such as blueberries, red cabbages purple sweet potatoes. Extensive studies have indicated anthocyanins strong antioxidant activities. To investigate mechanism of anthocyanidins an anticancer food source, six kinds representing aglycons most anthocyanins, were used examine their effects on tumor promotion in mouse JB6 cells, a validated model for screening cancer chemopreventive agents elucidating...
We recently described a soluble cell-free system derived from monkey cells that is capable of replicating exogenous plasmid DNA molecules containing the simian virus 40 (SV40) origin replication (J.J. Li, and T.J. Kelly, Proc. Natl. Acad. Sci. U.S.A. 81:6973-6977, 1984). Replication in completely dependent upon addition SV40 large T antigen. In this report we describe additional properties vitro reaction. Extracts prepared several nonsimian species were tested for ability to support...
To understand the role of HER2-associated signaling network in breast cancer stem cells (BCSC) using radioresistant and clinical recurrent cancers to evaluate HER2-targeted therapy as a tumor eliminating strategy for HER2(-/low) cancers.HER2-expressing BCSCs (HER2(+)/CD44(+)/CD24(-/low)) were isolated from radiation-treated MCF7 vivo irradiated xenograft tumors. Tumor aggressiveness radioresistance analyzed by gap filling, Matrigel invasion, tumor-sphere formation, clonogenic survival...
Kinesins are a superfamily of motor proteins and often deregulated in different cancers. However, the mechanism their deregulation has been poorly understood. Through examining kinesin gene family expression estrogen receptor (ER)-positive breast cancer cells, we found that stimulation cell proliferation involves concerted regulation specific kinesins. Estrogen strongly induces 19 genes such as Kif4A/4B, Kif5A/5B, Kif10, Kif11, Kif15, Kif18A/18B, Kif20A/20B, Kif21, Kif23, Kif24, Kif25,...
The molecular mechanisms governing acquired tumor resistance during radiotherapy remain to be elucidated. In breast cancer patients, overexpression of HER2 (human epidermal growth factor receptor 2) is correlated with aggressive and increased recurrence. the present study, we demonstrate that expression can induced by radiation in cells a low basal level HER2. Furthermore, HER2-postive tumors occur at much higher frequency recurrent invasive (59%) compared primary (41%). Interestingly,...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance metabolism meet the extra energy demands repair survive such genotoxic conditions. However, stress-induced adaptive metabolic alterations, especially in that radiotherapy, remain unresolved. In this study, we found CPT1 (Carnitine palmitoyl transferase I) CPT2 II), a pair of rate-limiting enzymes for mitochondrial fatty acid transportation, play critical role increasing oxidation (FAO) required...
Abstract Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program is strongly linked to nuclear receptor RORγ, compared estrogen receptor-positive cancer. Genetic and pharmacological inhibition RORγ reduces tumor cholesterol content synthesis rate while preserving host homeostasis. We demonstrate functions an essential activator the...
Abstract Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, immunosuppressive factors induced radiation on tumor cells remain to identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast (BC) and RT-treated mouse syngeneic BC. Co-expression both receptors more frequently detected recurrent BC patients poor prognosis. CD47 preferentially HER2-expressing cells, blocking or reduces...