A5100762713- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Electrochemical sensors and biosensors
- RNA Interference and Gene Delivery
- Genetic Mapping and Diversity in Plants and Animals
- Liver Disease Diagnosis and Treatment
- Plant Pathogens and Fungal Diseases
- Parasites and Host Interactions
- Genetic and phenotypic traits in livestock
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Natural Products and Biosynthesis
- Dental Implant Techniques and Outcomes
- thermodynamics and calorimetric analyses
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Meat and Animal Product Quality
- Insect Pheromone Research and Control
Shandong Provincial Hospital
2022-2025
Shandong First Medical University
2022-2025
Shandong Academy of Chinese Medicine
2023-2025
Shandong Center for Disease Control and Prevention
2025
Soochow University
2023-2024
Xijing Hospital
2022-2024
Northeast Normal University
2024
First Affiliated Hospital of Soochow University
2024
Air Force Medical University
2022-2024
Johns Hopkins Medicine
2024
β-catenin regulates the cross-talk among mature adipocytes, macrophages, and preadipocytes under overnutrition.
The conversion of feedstock materials into useful chemical compounds through feasible processes is highly sought after from both industrial and environmental perspectives. In this study, we developed a simple scalable protocol for synthesizing aldehydes, ketones, amides abundant raw materials, such as alkanes, alkenes, carboxylic acids. Using photoactive mesoporous graphitic carbon nitride catalyst (mpg-CN) molecular oxygen, successfully transformed over 60 substrates in good yield...
Obesity has spread worldwide and become a common health problem in modern society. One typical feature of obesity is the excessive accumulation fat adipocytes, which occurs through following two physiological phenomena: hyperplasia (increase quantity) hypertrophy size) adipocytes. In clinical scientific research, accurate quantification number diameter adipocytes necessary for assessing obesity. this study, we present new automatic adipocyte counting system, AdipoCount, based on image...
BackgroundIRX3 was recently reported as the effector of FTO variants. We aimed to test IRX3's roles in browning program and evaluate association between genetic variants IRX3 human obesity.MethodsIRX3 expression examined beige adipocytes mouse models, further validated induced adipocytes. The capacity primary preadipocytes assessed with knockdown. Luciferase reporter analysis ChIP assay were applied investigate effects on UCP1 transcriptional activity. Moreover, performed 861 young obese...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
Recent genetic evidence has linked WNT downstream mutations to fat distribution. However, the roles of WNTs in human obesity remain unclear. Here, authors screen all Wnt-related paracrine factors 1994 obese cases and 2161 controls using whole-exome sequencing (WES) identify that 12 patients harbor same RSPO1 (p.R219W/Q) predisposing obesity. is predominantly expressed visceral fat, primarily fibroblast cluster, increased with adiposity. Mice overexpressing adipose tissues develop under a...
Background Myocardial infarction is a cardiovascular disease that significantly contributes to global morbidity and disability. Given the significant role of diet in pathogenesis prevention diseases, this study rigorously investigates causal relationship between dietary habits myocardial infarction. Methods Results This used large‐scale genome‐wide association studies with pooled UK Biobank data explore associations 9 categories (83 types) A 2‐sample Mendelian randomization approach was...
Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution environmental pollutants frequent modern society. Silver nanoparticles (AgNPs) are widely used for bactericidal purpose various applications daily life. However, their potential toxicity and to epidemic not clear.Beige adipocytes newly discovered characterized by thermogenic energy dissipating capacity upon...
Abnormal epigenetic modifications are involved in the regulation of Warburg effect tumor cells. Protein arginine methyltransferases (PRMTs) mediate methylation and have critical functions cellular responses. PRMTs deregulated a variety cancers, but their precise roles cancer is largely unknown. Experiments from current study showed that PRMT1 was highly expressed under conditions glucose sufficiency. induced an increase PKM2/PKM1 ratio through upregulation PTBP1, turn, promoting aerobic...
Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying dominant-negative HNF1α P291fsinsC mutation (hHNF1Amut/-) and found that mutant mice developed steatosis spontaneously under normal chow diet. Transcriptome analysis showed significant upregulation of Cfd other genes related to innate immune response in hHNF1Amut/- mice. The changes lipid metabolism complement pathways were also confirmed by...
Produced by a newly isolated Streptomycetes strain, meijiemycin is gigantic linear polyene-polyol that exhibits structural features not seen in other members of the family. We propose biosynthetic mechanism and demonstrate inhibits hyphal growth inducing aggregation ergosterol restructuring fungal plasma membrane.
The pollen morphology of 15 species representing four sections Youngia and 11 from six other genera the tribe Cichorieae was investigated. Measurements observations were conducted through scanning electron microscopy. This study aims to provide new useful information regarding extent morphological diversity within genus related in thus contribute a better understanding taxonomy evolution these groups. Six types, distinguished primarily by number apertures spines polar region, are described....
In recent years, the impact of lipotoxicity on male fertility has received extensive attention, especially Sertoli cells (SCs). SCs, energy metabolism is important as disorders result in infertility eventually. However, underlying mechanism SCs remains unknown. Advances high-throughput metabolomics and lipidomics measurement platforms provide powerful tools to gain insights into complex biological systems. Here, we aimed explore potential molecular mechanisms palmitic acid (PA) regulating...
Canonical WNT pathway in mature adipocytes exacerbates obesity. In this study, we constructed UCP1-positive adipocytes-specific Ctnnb1 knockout mice (UBKO) and observed increased "browning" of white adipose tissue (WAT) following cold exposure or CL-316,243 administration compared to controls. UBKO also displayed energy expenditure. Furthermore, β-catenin (encoded by Ctnnb1) inhibited thermogenic genes expression differentiated beige repressed Ucp1 at transcription level. Transcriptome...
The Iroquois homeobox 3 (IRX3) gene was recently reported to be a functional downstream target of common polymorphism in the FTO gene, which encodes an obesity-associated protein; however, role IRX3 energy expenditure remains unclear. Studies have revealed that overexpression dominant-negative form mouse hypothalamus and adipose tissue promoted by enhancing brown/browning activities. Meanwhile, we others demonstrated knockdown impaired browning program primary preadipocytes vitro. In this...
Herein, a competitive-type electrochemiluminescence immunosensor for ultrasensitive detection of 5-fluorouracil (5-FU) was fabricated. Ruthenium(II)-metal-organic framework (Ru-MOF) nanosheets were selected to act promising ECL luminophore using tris(4,4'-dicarboxylic acid-2,2'-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)32+) as the organic ligand. The two-dimensional (2D) Ru-MOF achieved an increased loading Ru(dcbpy)32+ and effectively prevented leakage emitter during application, which...