A5100363357- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
- Andrographolide Research and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Healthcare and Venom Research
- Dietary Effects on Health
- PARP inhibition in cancer therapy
- Gut microbiota and health
- Lipid metabolism and disorders
- Virus-based gene therapy research
- Medicinal plant effects and applications
- Glycogen Storage Diseases and Myoclonus
- Ginger and Zingiberaceae research
- Peroxisome Proliferator-Activated Receptors
- Fungal Biology and Applications
Ruijin Hospital
2014-2025
Shanghai Jiao Tong University
2012-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2007-2020
Shanghai Clinical Research Center
2007-2018
Nanjing Agricultural University
2007
Berberine, a major pharmacological component of the Chinese herb Coptis chinensis, which was originally used to treat bacterial diarrhea, has recently been demonstrated be clinically effective in alleviating type 2 diabetes. In this study, we revealed that berberine effectively prevented development obesity and insulin resistance high-fat diet (HFD)-fed rats, showed decreased food intake. Increases levels serum lipopolysaccharide-binding protein, monocyte chemoattractant protein-1, leptin...
BackgroundIRX3 was recently reported as the effector of FTO variants. We aimed to test IRX3's roles in browning program and evaluate association between genetic variants IRX3 human obesity.MethodsIRX3 expression examined beige adipocytes mouse models, further validated induced adipocytes. The capacity primary preadipocytes assessed with knockdown. Luciferase reporter analysis ChIP assay were applied investigate effects on UCP1 transcriptional activity. Moreover, performed 861 young obese...
The prevalence of non-alcoholic fatty liver disease (NAFLD), a condition characterized by an excessive accumulation triglycerides (TGs) in hepatocytes, has dramatically increased globally during recent decades. MicroRNAs (miRs) have been suggested to play crucial roles many complex diseases and lipid metabolism. Our results indicated that miR199a-5p was remarkably upregulated free acid (FA)-treated hepatocytes. To investigate the role pathogenesis potential mechanism which regulates NAFLD,...
The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide indicates the urgent need to develop novel and effective treatment strategies. Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has an outstanding effect in improving metabolism. However, pharmacological action mechanism BA NAFLD remain unclear. Here, we show that BA-treated high-fat diet mice methionine-choline deficient diet-fed are resistant hepatic steatosis when compared...
Introduction . Obesity has an unclear pathogenesis. MicroRNAs (miRNAs) may function as biologically active molecules for obesity through regulating adipocyte differentiation. This study aimed to identify how miR-129-5p (a specific miRNA) regulates adipogenesis in vitro and explore its possible role the pathogenesis of humans. Materials Methods The expression was detected obese mouse models. effect on differentiation observed, adipose markers were analyzed. Bioinformatics dual-luciferase...
Aquaporin-8(AQP8), is a transmembrane channel protein that abounds in liver, which mainly promotes water transport, modulating bile acid formation. However, its role hepatic lipid metabolism remains unclear. In this study, we found the expression of AQP8 was reduced liver specimens patients with NAFLD, high-fat diet (HFD)-induced mice and genetically obese db/db mice. Knockdown hepatocytes exacerbated intracellular accumulation induced by free fatty (FFA) mixtures. contrast, overexpression...
Abstract MicroRNAs (miRNAs) are known to contribute many metabolic diseases, including diabetes. In this study, we investigated the role of miR199a-5p in regulation hepatic insulin sensitivity. Ad-anti-miR199a-5p adenoviruses were injected into male C57BL/6J WT mice fed a high-fat diet inhibit expression before glucose levels and resistance assessed. Similarly, Ad-miR199a-5p cause overexpression miR199a-5p. To investigate roles autophagy-related protein 14 (ATG14) sensitivity, with or...
Purpose: To investigate the protective effect of Evodia rutaecarpa (Juss.) Benth. extract (ERBE) against Alzheimer's disease in 3xTg-AD mice.
 Methods: The cognitive function mice was assessed using Morris water maze test. levels amyloid beta deposits and NeuN mouse hippocampus were evaluated by immunohistochemistry. Brain neurotrophic derived factor (BDNF) tyrosine kinase B (TrkB) expressions determined western blot analysis.
 Results: ERBE treatment significantly ameliorated...
Background: We recently reported that cardiac expression of the antioxidant metallothionein (MT) was increased by acute expsorue to intermittent hypoxia (IH), and protected from chronic IH-induced cardiomyopathy. However, how IH stimulates MT in heart remains unclear. Here we tried define whether nuclear factor erythroid 2-related 2 (Nrf2), a critical redox-balance controller body, protects cardiomyopathy its relationship with MT, Nrf2 are indispensable for sulforaphane (SFN) prevention...