A5051219110- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Apelin-related biomedical research
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Exercise and Physiological Responses
- Neuroendocrine regulation and behavior
- Extracellular vesicles in disease
- Plasma Diagnostics and Applications
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Neuroscience of respiration and sleep
- Neurobiology and Insect Physiology Research
- COVID-19 Impact on Reproduction
- Mitochondrial Function and Pathology
- Plasma Applications and Diagnostics
- Muscle Physiology and Disorders
Albert Einstein College of Medicine
2014-2024
Shanghai Jiao Tong University
2023-2024
The Bronx Defenders
2013
Institute of Aging
2013
University of Wisconsin–Madison
2008-2011
Joslin Diabetes Center
2003-2008
Harvard University
2003-2008
Brigham and Women's Hospital
2005
Abstract Objectives: Chronic subacute inflammation is implicated in the pathogenesis of insulin resistance and type 2 diabetes. Salicylates were shown years ago to lower glucose more recently inhibit NF‐κB activity. Salsalate, a prodrug form salicylate, has seen extensive clinical use favorable safety profile. We studied efficacy salsalate reducing glycemia potential mechanisms action validate as pharmacologic target Methods Results: In open label studies, both high (4.5 g/d) standard (3.0...
We have identified two new human genes that encode proteins with tandem pleckstrin homology-phosphotyrosine binding (PH-PTB) domains at their amino termini. Because the other known PH-PTB (insulin receptor substrates: IRS-1, IRS-2, IRS-3, and IRS-4, downstream of kinases: DOK-1, DOK-2, DOK-3) are substrates insulin insulin-like growth factor (IGF)-1 receptors, we asked whether these proteins, termed IRS5/DOK4 IRS6/DOK5, might also roles in IGF-1 signaling. Northern analyses indicate is...
Chronic endoplasmic reticulum (ER) stress was recently revealed to affect hypothalamic neuroendocrine pathways that regulate feeding and body weight. However, it remains unexplored whether brain ER could use a neural route rapidly cause the peripheral disorders underlie development of type 2 diabetes (T2D) metabolic syndrome. Using pharmacologic model delivered inducer thapsigargin into brain, this study demonstrated short-term over 3 d sufficient induce glucose intolerance, systemic hepatic...
The obesity pandemic can be viewed as a result of an imbalanced reaction to changing environmental factors. Recent research has linked circadian arrhythmicity and related diseases; however, the underlying mechanisms are still unclear. In this study, we found that high-fat diet (HFD) feeding strikingly promoted daytime rather than nighttime caloric intake in mice, leading arrhythmicity. Using scheduled with defined amount daily HFD intake, increase ratio weight gain, whereas decrease...
Hepatosteatosis is characterized by an aberrant accumulation of triglycerides in the liver; however, factors that drive obesity-induced fatty liver remain largely unknown. Here, we demonstrated secreted cell adhesion protein periostin markedly upregulated livers obese rodents and humans. Notably, overexpression WT mice promoted hepatic steatosis hypertriglyceridemia. Conversely, both genetic ablation administration a periostin-neutralizing antibody dramatically improved hepatosteatosis...
Abstract The histological spectrum of nonalcoholic fatty liver diseases (NAFLD) ranges from hepatic steatosis to steatohepatitis and fibrosis. Berberine (BBR) is known for its therapeutic effect on obesity, hyperglycaemia dyslipidaemia; however, NAFLD has yet be thoroughly explored. Db/db mice methionine-choline-deficient diet-fed were administered BBR via gavage. We found that BBR-treated more resistant in the than vehicle-treated significantly reduced inflammation, fibrosis lipid...
Nuclear factor-κB (NF-κB) is a transcription factor with important roles in regulating innate immune and inflammatory responses. NF-κB activated through the phosphorylation of its inhibitor, IκB, by IκB kinase (IKK) complex. Physical exercise elicits changes skeletal muscle gene expression, yet signaling cascades factors involved remain largely unknown. To determine whether regulated vivo, rats were run on motorized treadmill for 5–60 min. Exercise resulted up to twofold increases IKKα/β...
Hypoxia-inducible factor (HIF) is a nuclear transcription that responds to environmental and pathological hypoxia induce metabolic adaptation, vascular growth, cell survival. Here we found HIF subunits HIF2α in particular were normally expressed the mediobasal hypothalamus of mice. Hypothalamic was up-regulated by glucose mediate feeding control hypothalamic sensing. Two underlying molecular pathways identified, including suppression PHDs metabolites prevent degradation recruitment AMPK...