A5016791091- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Kruppel-like factors research
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Renal and related cancers
- Anesthesia and Neurotoxicity Research
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Developmental Biology and Gene Regulation
- Angiogenesis and VEGF in Cancer
- Vascular Malformations Diagnosis and Treatment
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Advanced Breast Cancer Therapies
- Reproductive Biology and Fertility
- Immune Response and Inflammation
- interferon and immune responses
- Erythrocyte Function and Pathophysiology
- Congenital heart defects research
- Cancer Research and Treatments
Chinese Academy of Sciences
2016-2025
Center for Excellence in Molecular Cell Science
2014-2025
University of Chinese Academy of Sciences
2017-2025
Fudan University Shanghai Cancer Center
2025
Fujian Medical University
2025
Boston University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Southern Medical University
2023
Beijing Hospital
2023
Zhujiang Hospital
2023
Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function corresponding vivo tissue. They can be dissected interrogated for fundamental mechanistic studies on development, regeneration, repair human tissues. also used diagnostics, disease modeling, drug discovery, personalized medicine. derived from either pluripotent or tissue-resident stem (embryonic adult)...
Vascular growth and remodeling are dependent on the generation of new endothelial cells from stem involvement perivascular to maintain vessel integrity function. The existence cellular identity vascular (VESCs) remain unclear. pericytes in adult tissues thought arise recruitment differentiation mesenchymal progenitors during early development. In this study, we identified Protein C receptor-expressing (Procr+) as VESCs multiple tissues. Procr+ exhibit robust clonogenicity culture, high...
Administration of exogenous epidermal growth factor (EGF) improves testicular injury after acute ischemia-reperfusion (IR) stress, but the molecular basis is poorly understood. The role endogenous EGF in recovery and underlying intracellular signaling pathways involved were herein investigated. In mice, IR significantly enhanced expression level Egf at very beginning reperfusion. Expression receptor (Egfr (ErbB1)) was accordingly upregulated 3 h Deprivation majority circulated by...
Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that characterised by capillary-venous cavernomas, and due to loss-of-function mutations any one of three CCM genes. Familial follows two-hit mechanism similar tumour suppressor genes, while in cavernomas only small fraction endothelial cells shows mutated We reported mouse models human patients, lining the lesions have different features from surrounding endothelium, as they express mesenchymal/stem-cell...
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and nuclear levels are inversely proportional to cellular proliferation, suggesting activation the Wnt/β-catenin pathway may provide benefit for patients. In order further probe this concept we tested LY2090314, potent selective small-molecule inhibitor activity against GSK3α GSK3β isoforms. panel cell lines, nM concentrations LY2090314 stimulated TCF/LEF TOPFlash reporter activity,...
The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation apoptosis. How this triggers apoptosis remains largely unexplored. Here, we identify NR4A1 as a target the that mediates pro-apoptotic anti-tumor effects whereby YAP regulates transcription, phosphorylation, mitochondrial localization NR4A1. NR4A1, in turn, functions feedback inhibitor to promote its degradation, thereby inhibiting function during liver regeneration tumorigenesis....
The Hippo pathway plays a critical role in cell growth and tumorigenesis. activity of TEA domain transcription factor 4 (TEAD4) determines the output signaling; however, regulation function TEAD4 has not been explored extensively. Here, we identified glucocorticoids (GC) as novel activators TEAD4. GC treatment facilitated glucocorticoid receptor (GR)-dependent nuclear accumulation transcriptional activation positively correlated with GR expression human breast cancer, high predicted poor...
Signals from the niche play pivotal roles in regulating adult stem cell self-renewal. Previous studies indicated that steroid hormones can expand mammary cells (MaSCs) vivo. However, facilitating local factors directly contribute to MaSC expansion remain unclear. Here we identify R-spondin1 (Rspo1) as a novel hormonal mediator gland. Pregnancy and treatment up-regulate Rspo1 expression. cooperates with another mediator, Wnt4, promote self-renewal through Wnt/β-catenin signaling. Knockdown of...
Permanent hearing loss is caused by the irreversible damage of cochlear sensory hair cells and nonsensory supporting cells. In postnatal cochlea, epithelium terminally differentiated, whereas tympanic border (TBCs) beneath are proliferative. The functions TBCs poorly characterized. Using an Axin2(lacZ) Wnt reporter mouse, we found transient but robust signaling proliferation in during first 3 weeks, when number decreases. vivo lineage tracing shows that a subset derived postnatally from...
Adipocyte is the most predominant cell type in tumor microenvironment of breast cancer and plays a pivotal role progression, yet underlying mechanisms functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads human patients generated mature adipocytes cancer-associated (CAAs) vitro. The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing. One highly expressed genes granulocyte colony-stimulating factor...
Maintenance of undifferentiated, long-lived, and often quiescent stem cells in the basal compartment is important for homeostasis regeneration multiple epithelial tissues, but molecular mechanisms that coordinately control cell fate quiescence are elusive. Here, we report an epithelium-intrinsic requirement Zeb1, a core transcriptional inducer epithelial-to-mesenchymal transition, mammary ductal side branching regenerative capacity. Our findings uncover evolutionarily conserved role Zeb1...
Drosophila Nemo is the founding member of Nemo-like kinase (Nlk) family serine/threonine protein kinases that are involved in several Wnt signal transduction pathways. Here we report a novel function for inhibition bone morphogenetic (BMP) signaling. Genetic interaction studies demonstrate nemo can antagonize BMP signaling and inhibit expression target genes during wing development. bind to phosphorylate effector Mad. In cell culture, phosphorylation by blocks nuclear accumulation Mad...
Proper control of apoptotic signaling is important for maintenance testicular homeostasis after ionizing radiation (IR). Herein, we challenged the hypothesis that ghrelin, a pleiotropic modulator, potentially involved in IR-induced germ cell injury. Lower body exposure to 2 Gy IR induced notable increase ghrelin expression nuclear differentiating spermatogonia at defined stages, with an impairment Leydig cells (LCs)-expressing ghrelin. Unexpectedly, inhibition pathway by intraperitoneal...
// Bruce W. Konicek 1 , Andrew R. Capen Kelly M. Credille Philip J. Ebert Beverly L. Falcon Gary Heady Bharvin K.R. Patel Victoria Peek Jennifer Stephens Julie A. Stewart Stephanie Stout David E. Timm Suzane Um Melinda D. Willard Isabella H. Wulur Yi Zeng Yong Wang Richard Walgren and Sau-Chi Betty Yan Lilly Research Laboratories, Eli Company, Indianapolis, IN 46285, USA Correspondence to: Konicek, email: konicek_bruce_w@lilly.com Keywords: NTRK fusion; merestinib; LY2801653; inhibitor; type...