A5100362629- Liver Disease Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Liver Disease and Transplantation
- Medical Imaging and Analysis
- Diabetes and associated disorders
- Scoliosis diagnosis and treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Diet, Metabolism, and Disease
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Lung Cancer Treatments and Mutations
- Cervical and Thoracic Myelopathy
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Pancreatitis Pathology and Treatment
- Ferroptosis and cancer prognosis
Queen Mary University of London
2017-2025
Zhongshan People's Hospital
2024-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021-2025
Peking University
2019-2025
Beijing Hospital of Traditional Chinese Medicine
2024-2025
Capital Medical University
2024-2025
Sun Yat-sen University
2022-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2022-2025
Sichuan University
2019-2024
West China Hospital of Sichuan University
2022-2024
Abstract Background Recent studies have suggested that vitamin D deficiency in children is widespread. But the status of Chinese seldom investigated. The objective present study was to survey serum levels 25-hydroxyvitamin [25(OH)D] more than 6,000 aged 1 month 16 years Hangzhou (latitude: 30°N), capital Zhejiang Province, southeast China. Methods who came child health care department our hospital, children's hospital affiliated university school medicine, for examination were taken blood...
Liver fibrosis is a serious liver disease associated with high morbidity and mortality. The activation of hepatic stellate cells (HSCs) the overproduction extracellular matrix proteins are key features during progression. In this work, chondroitin sulfate nanomicelles (CSmicelles) were developed as delivery system targeting HSCs for treatment fibrosis. CS-deoxycholic acid conjugates (CS-DOCA) synthesized via amide bond formation. Next, retinoic (RA) doxorubicin (DOX) encapsulated into...
Hepatic fibrosis is one kind of liver diseases with a high mortality rate and incidence. The activation proliferation hepatic stellate cells (HSCs) the most fundamental reason fibrosis. There are no specific effective drug delivery carriers for treatment at present. We found that when occurs, expression CD44 receptors on surface HSCs significantly increased. Based this finding, we designed silibinin-loaded hyaluronic acid (SLB-HA) micelles to achieve Meanwhile, constructed rat model using...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by prominent loss of nigrostriatal dopamine (DA) neurons with an accompanying neuroinflammation. The peptide angiotensin II (AngII) plays role in oxidative-stress induced disorders and thought to mediate its detrimental actions via activation AngII AT1 receptors. brain renin-angiotensin system implicated including PD. Blockade the converting enzyme or receptors provides protection acute animal models...
Vitamin D deficiency has been reported to associate with the impaired development of antigen-specific responses following vaccination. We aimed determine whether vitamin supplements might boost immunogenicity and efficacy SARS-CoV-2 vaccination by conducting three sub-studies nested within CORONAVIT randomised controlled trial, which investigated effects offering at a dose 800 IU/day or 3200 vs. no offer on risk acute respiratory infections in UK adults circulating 25-hydroxyvitamin...
Proper control of apoptotic signaling is important for maintenance testicular homeostasis after ionizing radiation (IR). Herein, we challenged the hypothesis that ghrelin, a pleiotropic modulator, potentially involved in IR-induced germ cell injury. Lower body exposure to 2 Gy IR induced notable increase ghrelin expression nuclear differentiating spermatogonia at defined stages, with an impairment Leydig cells (LCs)-expressing ghrelin. Unexpectedly, inhibition pathway by intraperitoneal...
Spinal cord injury (SCI) affects more than 2.5 million people worldwide. edema plays critical roles in the pathological progression of SCI. This study aimed to delineate aquaporin 4 (AQP4) and Na+-K+-Cl- cotransporter 1 (NKCC1) acute phase tissue destruction after SCI explore whether inhibiting both AQP4 NKCC1 could improve SCI-induced spinal damage. Rat model was established by modified Allen's method. water content, cerebrospinal fluid lactose dehydrogenase (LDH) activity, expression,...
Study Design Retrospective study. Objective This retrospective study primary focus is to investigate the relationship between C-VBQ score and occurrence of postoperative zero-profile anchored spacer (ROI-C) interbody fusion cage subsidence. Additionally, we aim evaluate predictive efficacy scoring system for subsidence in context ACDF with ROI-C. Methods Patients who underwent ROI-C at our hospital January 2016 December 2022 were included this Univariate analysis multivariate logistic...
Significance Autism is a childhood neurodevelopmental disorder affecting approximately 1 in 70 children the United States. Some parents believe that thimerosal-containing vaccines and/or measles, mumps, rubella (MMR) vaccine are involved etiology of autism. Here we gave nonhuman primate infants similar given to human determine whether animals exhibited behavioral neuropathological changes characteristic No were observed vaccinated animals, nor there cerebellum, hippocampus, or amygdala. This...
Abstract Hemorrhagic fever with renal syndrome (HFRS), caused by hantavirus , is a serious public health problem in China. Despite intensive countermeasures including Patriotic Health Campaign, rodent control and vaccination affected areas, HFRS still potential threat China, more than 10,000 new cases per year. Previous epidemiological evidence suggested that meteorological factors could influence incidence, but the studies were mainly limited to specific city or region This study aims...
In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk exposure, including household overcrowding, public transport use, visits to indoor places. Anti-spike IgG/A/M showed positive...
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of worldwide, with an estimated prevalence 25% in Western World. NAFLD a broad spectrum states and while people do not have progressive disease, 10-20% patients develop histological features inflammation (non-alcoholic steatohepatitis), fibrosis, cirrhosis its complications. Despite this large burden significant clinical impact, living are undiagnosed, course prediction imprecise there no treatments licensed for condition. In...
Laparoscopic-assisted single-port mediastinoscopic esophagectomy is a safe and effective emerging minimally invasive esophagectomy, but little has been reported about the learning curve for this technology. The goal of study was to determine number procedures achieve different levels proficiency on curve. This retrospectively analyzed data from consecutive surgeries performed by same surgeon at center 2016 2021. Learning curves were quantitatively assessed unadjusted cumulative sums,...
ABSTRACT Objective Cervical degeneration involves many pathophysiological changes. Vertebral bone loss, sclerotic hyperplasia of the vertebral body and intervertebral disc (IDD) are most common degenerative factors. However, whether there is a correlation between changes in mass IDD remains unclear. In this study, based on magnetic resonance imaging (MRI), Pfirrmann method was used to grade cervical degeneration, quality (VBQ) measured. The VBQ analyzed, its potential mechanism discussed as...
Interventions that promote the proliferation of endogenous neural stem cells (ENSCs) and induce their differentiation into neurons after spinal cord injury (SCI) hold significant potential for SCI repair. Tanshinone IIA (TIIA) exhibits extensive neuroprotective effects, its derivative, sodium tanshinone sulfonate (STS), has enhanced water solubility, making it easier to prepare injectable formulations increasing bioavailability. STS injections have been extensively utilized in treatment...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Current international guidelines recommend 6-monthly ultrasound surveillance in all patients with cirrhosis and those hepatitis B virus-related risk factors to detect early-stage HCC. However, it unknown whether the benefits are comparable across patient groups underlying disease-related factors. We aimed evaluate patient- associated HCC stage at diagnosis survival an ethnically diverse UK population. This was...
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent specific chronic respiratory diseases. It could worsen development cardiovascular diseases (CVD) and lung cancer. We aimed to elucidate relationship between use angiotensin receptor blockers (ARBs) incidence cancer among COPD population in China. This retrospective cohort included patients identified by international classification 10th edition (ICD-10) codes Yinzhou Regional Health Care Database. The ARBs was defined...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental characterized by impairments in social interaction and communication restricted, repetitive patterns of behavior. In order to identify individuals with ASD initiate interventions at the earliest possible age, biomarkers for are desirable. Research findings have identified widespread changes immune system children autism, both systemic cellular levels. an attempt find candidate antibody ASD, highly complex libraries peptoids...
<h3>ABSTRACT</h3> Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic worldwide. NAFLD defined by excess fat in and has a multidirectional relationship with metabolic syndrome. The prevalence risen rapidly recent years line obesity epidemic associated increases type 2 diabetes, hypertension hypercholesterolaemia. Patients are at risk cardiovascular cancer, proportion individuals, damage. This article summarises epidemiology NAFLD, clinical approach to risk-assessing...