A5028833857- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Proteoglycans and glycosaminoglycans research
- Pharmacogenetics and Drug Metabolism
- Acute Kidney Injury Research
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Circular RNAs in diseases
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Dialysis and Renal Disease Management
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- Advanced biosensing and bioanalysis techniques
- Natural Compounds in Disease Treatment
- Immune Response and Inflammation
Sichuan University
2016-2025
Harbin Medical University
2015-2025
Qingdao University
2021-2025
Affiliated Hospital of Qingdao University
2021-2025
First Affiliated Hospital of Harbin Medical University
2017-2025
Command Hospital
2025
Shenzhen Institute of Innovation Design (China)
2025
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Wuxi People's Hospital
2023-2024
Mesangial cells-mediated glomerulonephritis is a frequent cause of end-stage renal disease. Here, we show that celastrol effective in treating both reversible and irreversible mesangioproliferative rat models, but find its off-target distributions severe systemic toxicity. We thus target to mesangial cells using albumin nanoparticles. Celastrol-albumin nanoparticles crosses fenestrated endothelium accumulates cells, alleviating proteinuria, inflammation, glomerular hypercellularity,...
Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report efficacy of celastrol as promising compound for treatment pancreatic carcinoma via naïve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles. Neutrophil nanoparticles (NNPs) are well demonstrated overcome blood pancreas barrier achieve...
Metastasis is a multistep biological process regulated by multiple signaling pathways. The integrity of the Golgi apparatus plays an important role in these Inspired mechanism and our previous finding about accumulation chondroitin sulfate hepatic stellate cells, we developed apparatus-targeting prodrug nanoparticle system synthesizing retinoic acid (RA)-conjugated (CS) (CS–RA). nanoparticles appeared to accumulate cancer cells realized RA release under acidic environment. We confirmed that...
Liver fibrosis is a serious liver disease associated with high morbidity and mortality. The activation of hepatic stellate cells (HSCs) the overproduction extracellular matrix proteins are key features during progression. In this work, chondroitin sulfate nanomicelles (CSmicelles) were developed as delivery system targeting HSCs for treatment fibrosis. CS-deoxycholic acid conjugates (CS-DOCA) synthesized via amide bond formation. Next, retinoic (RA) doxorubicin (DOX) encapsulated into...
Objective To quantify functional age‐related changes in the cartilage antioxidant network order to discover novel mediators of oxidative stress and osteoarthritis (OA) pathophysiology. Methods We evaluated histopathologic knee OA 10‐, 20‐, 30‐month‐old male F344BN rats analyzed oxidation according ratio reduced oxidized glutathione. Antioxidant gene expression protein abundance were by quantitative reverse transcription–polymerase chain reaction selected reaction–monitoring mass...
Hepatic fibrosis is one kind of liver diseases with a high mortality rate and incidence. The activation proliferation hepatic stellate cells (HSCs) the most fundamental reason fibrosis. There are no specific effective drug delivery carriers for treatment at present. We found that when occurs, expression CD44 receptors on surface HSCs significantly increased. Based this finding, we designed silibinin-loaded hyaluronic acid (SLB-HA) micelles to achieve Meanwhile, constructed rat model using...
Toll-like receptors (TLR) play a dual regulatory role in the tumor microenvironment (TME). TLR agonists (TLRa) elicit both innate and adaptive immune responses to achieve anti-tumor effects, whereas inflammatory response induced by TLRa contributes escape of cells. Preliminary evidences suggest that result antitumor effects can be explored as vaccine adjuvants preclinical clinical models, however, only few obtained FDA approval for studies. Meanwhile, antagonists are anti-inflammatory...
Abstract The blood–brain barrier (BBB) is a highly regulated and efficient that controls the mass transfer between blood brain, severely limits brain penetration of systemically administered therapeutics. During onset progression tumors, BBB alters, tumor (BBTB) forms. Though BBTB differs from in certain aspects, such as neuronal connections aberrant pericyte distribution, it retains critical aspects BBB. Hence, one major challenge development therapeutics for to achieve sufficient thus...
Abstract Conducting polymers are mixed ionic–electronic conductors that emerging candidates for neuromorphic computing, bioelectronics and thermoelectrics. However, fundamental aspects of their many-body correlated electron–ion transport physics remain poorly understood. Here we show in p-type organic electrochemical transistors it is possible to remove all the electrons from valence band even access deeper bands without degradation. By adding a second, field-effect gate electrode,...
In our study, we aimed to develop a codelivery nanoparticulate system of pirarubicin (THP) and paclitaxel (PTX) (Co-AN) using human serum albumin improve the therapeutic effect reduce systemic toxicities. The prepared Co-AN demonstrated narrow size distribution around 156.9 ± 3.2 nm (PDI = 0.16 0.02) high loading efficiency (87.91 2.85% for THP 80.20 2.21% PTX) with sustained release profiles. Significantly higher drug accumulation in tumors decreased normal tissues were observed xenograft...
Multidrug resistance has remained a major cause of treatment failure in chemotherapy due to the presence P-glycoproteins (P-gp) that actively pump drugs from inside cell outside. P-gp inhibitors were developed and coadministered with chemotherapeutic overcome effect efflux pumps thus enhancing chemosensitivity therapeutics. Our study aimed at developing lipid nanoemulsion system for coencapsulation doxorubicin (DOX) bromotetrandrine (W198) reverse multidrug (MDR) breast cancer. W198 was...
A safe and efficient tumor-targeting strategy based on oligomeric hyaluronic acid (HA) modification coadministration of tumor-penetrating peptide-iRGD was successfully developed. In this study, common liposomes (cLip) were modified by HA to obtain HA-Lip. After injection into rats, HA-Lip showed good stealth in the bloodstream lower liver distribution compared with cLip. Moreover, our could be internalized B16F10 cells (CD44-overexpressing tumor cells) through HA-CD44 interaction. systemic...
PEGylated liposomes (PEG-Lip) have been widely used as a drug carrier for their good stealth property in blood circulation. However, the second injection of PEG-Lip was reported to result accelerated clearance (ABC) phenomenon and trigger hypersensitivity reactions sensitive individuals its complement activation effect. To avoid adverse immune responses, HA selected modify afford modified (HA-Lip). Repeated administrations HA-Lip were performed rats. Our results showed that induced ABC...
The expression and function of long noncoding RNAs (lncRNAs) in the development hypoxic pulmonary hypertension (HPH), especially proliferation artery smooth muscle cells (PASMCs), are largely unknown. Herein, we examined role lncRNA-maternally expressed gene 3 (lncRNA-MEG3) HPH. lncRNA-MEG3 was significantly increased primarily localized cytoplasm PASMCs. knockdown by lung-specific delivery small interfering (siRNAs) inhibited HPH vivo. Silencing siRNAs gapmers attenuated cell-cycle...
Selective targeting of drugs to kidneys may improve renal effectiveness and reduce extrarenal toxicity. Using fluorescence imaging, we found for the first time that randomly 50% N-acetylated low molecular weight chitosan (LMWC) selectively accumulated in kidneys, especially tubules after i.v. injection mice. To develop evaluate novel drug carrier, prednisolone, used as a model drug, was covalently coupled with various LMWCs via succinic acid spacer. The mean residence (MRT) plasma...
Phospholipid complex (PLC) based self-nanoemulsifying drug delivery system (PLC-SNEDDS) has been developed for efficient of drugs with poor solubility and low permeability. In the present study, a BCS class IV P-glycoprotein (P-gp) substrate, morin, was selected as model to elucidate oral absorption mechanism PLC-SNEDDS. PLC-SNEDDS superior PLC in protecting morin from degradation by intestinal enzymes vitro. situ perfusion study showed increased permeability duodenum-specific. contrast, all...