A5100375615- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Ion channel regulation and function
- Cardiovascular Health and Disease Prevention
- Pulmonary Hypertension Research and Treatments
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Autophagy in Disease and Therapy
- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Retinal Imaging and Analysis
- Cancer, Hypoxia, and Metabolism
- Yeasts and Rust Fungi Studies
- Genomics, phytochemicals, and oxidative stress
Tianjin Central Hospital of Gynecology Obstetrics
2024-2025
Wuhan University
2023-2025
Zhongnan Hospital of Wuhan University
2023-2025
Qingdao University
2025
Educational Department of Liaoning Province
2025
Jiangsu Normal University
2023-2025
Inner Mongolia Medical University
2025
China Medical University
2021-2025
Nankai University
2024
Dalian Medical University
2018-2024
Circular RNAs (circRNAs) have recently emerged as a new family of noncoding that are involved in the causation and progression various cancers. However, roles circRNAs tumorigenesis gastric cancer (GC) still largely unknown.The expression profiles GC were identified open GEO database evaluated at mRNA level clinical samples compared with paired non-tumorous tissues. Kaplan-Meier survival curve was used to analyze correlation circRNA patients' prognosis. Subsequently, circular structures...
Significance Ischemic retinopathies include a diverse group of diseases in which immature retinal vasculature or damage to mature vessels leads ischemia. The anticipated rise the worldwide prevalence diabetes will result concurrent increase number patients with vision impairment from diabetic eye disease, most common cause ischemic retinopathy. We set out identify novel hypoxia-inducible genes that promote vascular permeability and may therefore play role pathogenesis disease. demonstrate...
Article AbstractObjective: Although cannabis is the most widely abused illicit drug, little known about prevalence of withdrawal and its factor structure, clinical validity, psychiatric correlates in general population. Method: National Epidemiologic Survey on Alcohol Related Conditions participants were assessed, 2001-2002, with structured in-person interviews covering substance history, DSM-IV Axis I II disorders, symptoms after cessation use. Of these, 2613 had been frequent users ( >= 3...
// Na Chen 1, 2, * , Dan Guo 3, Qiong Xu 2 Minhui Yang Wang 1 Man Peng Yanqing Ding Shuang Jun Zhou Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China School Basic Sciences, 3 Pharmacy, These authors contributed equally to this work Correspondence to: Zhou, e-mail: jzhou16@163.com Wang, shuangw@126.com Keywords: FEZF1-AS1, FEZF1, colorectal cancer, long non-coding RNA Received: July 16, 2015 Accepted: January 21,...
Recent studies indicate that circular RNA (circRNA) is involved in tumorigenesis, but its role triple-negative breast cancer (TNBC) remains largely unknown. In this study, we characterized the of circ-ITCH TNBC and found was significantly down-regulated tissues cell lines closely associated with poor prognosis. We therefore constructed MDA-MB-231 BT-549 stably expressing by lentiviral vectors to determine underlying mechanisms progression. Most importantly, over-expression remarkably...
Retinitis pigmentosa (RP) encompasses a diverse group of Mendelian disorders leading to progressive degeneration rods and then cones. For reasons that remain unclear, diseased RP photoreceptors begin deteriorate, eventually cell death and, consequently, loss vision. Here, we have hypothesized associated with mutations in phosphodiesterase-6 (PDE6) provokes metabolic aberration rod cells promotes the pathological consequences elevated cGMP Ca2+, which are induced by Pde6 mutation. Inhibition...
Abstract Recent studies have furthered our understanding of the function long noncoding RNAs (lncRNAs) in numerous biological processes, including cancer. This study investigated expression a novel lncRNA, colorectal neoplasia differentially expressed ( CRNDE ), carcinoma (CRC) tissues and cells by real-time RT-PCR situ hybridization, its using series vitro vivo experiments to determine potential as prognostic marker therapeutic target. was found be upregulated primary CRC P <0.05),...
Long noncoding RNAs (lncRNAs) have been indicated to play critical roles in cancer development and progression. LncRNA HOXD cluster antisense RNA1 (HOXD-AS1) has recently found be dysregulated several cancers. However, the expression levels, cellular localization, precise function mechanism of HOXD-AS1 colorectal carcinoma (CRC) are largely unknown.Real-time PCR situ hybridization were used detect CRC tissue samples cell lines. Gain- loss-of-function experiments performed investigate...
Accumulating evidence suggests that long noncoding RNA (lncRNA) plays important regulatory roles in cancer biology. However, the involvement of lncRNA colorectal carcinoma progression remains largely unknown, especially metastasis. In this study, we investigated changes expression and identified a new lncRNA, antisense transcript SATB2 (SATB2-AS1), as key regulator progression. SATB2-AS1 was frequently downregulated cells tissues, patients whose tumors expressed at low levels had shorter...
Abstract Background Circular RNAs (circRNAs), a class of noncoding (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. However, there is large gap the knowledge about circDOCK1 and its biological functions osteogenic sarcoma (OS). Methods Differentially expressed OS cell lines tissues were identified circRNA microarray analysis quantitative real-time PCR (qRT–PCR). To explore actions vivo...
CGAS-STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion-targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)-derived type I photosensitizer (BDP) Au nanoparticle-engineered hollow mesoporous silica (HMSN/AuNPs) has been fabricated for light-controlled mitochondrial stress-inducing agonist-independent cGAS-STING pathway activation. The HABH can actively target tumor tissues release...
A total of 807 entire VP1 sequences Coxsackievirus A6 (CV-A6) from mainland China 1992 to 2015, including 520 in this study and 287 the GenBank database, were analysed provide a basic framework molecular epidemiological characteristics CV-A6 China. Sixty-five 46 representative isolates Chinese strains 19 international used for describing genotypes sub-genotypes. The results revealed that can be categorised into 4 designated as A, B, C, D according previous data further subdivided B1-B2,...
Abstract Protein regulator of cytokinesis 1 (PRC1) has been reported in correlation with various malignancies. Functionality PRC1 nasopharyngeal carcinoma (NPC) was investigated, perspective long noncoding RNA (lncRNA) regulatory circuitry. Aberrant expressed messenger and lncRNA were screened out from the Gene Expression Omnibus microarray database. NPC cell line CNE‐2 adopted for vitro study transfected mimic or short hairpin miR‐194‐3p PTPRG‐AS1. The radioactive sensitivity, viability,...
The expression and function of long noncoding RNAs (lncRNAs) in the development hypoxic pulmonary hypertension (HPH), especially proliferation artery smooth muscle cells (PASMCs), are largely unknown. Herein, we examined role lncRNA-maternally expressed gene 3 (lncRNA-MEG3) HPH. lncRNA-MEG3 was significantly increased primarily localized cytoplasm PASMCs. knockdown by lung-specific delivery small interfering (siRNAs) inhibited HPH vivo. Silencing siRNAs gapmers attenuated cell-cycle...
Background Thyroid hormone withdrawal (THW) in postoperative thyroid cancer patients who need always accompanied by complications (e.g., dyslipidemia and constipation). At present, there are no effective safe means to alleviate these complications. Purpose We aimed assess the oral-gut microbiota profiles THW then investigate whether probiotics could alleviating related therapeutic effects were associated with state. Methods Fifty eligible carcinoma undergoing thyroidectomy randomly assigned...
To assess the diagnostic accuracy of AccuIMR, a newly proposed, pressure wire-free index, in identifying coronary microvascular dysfunction (CMD) among patients with acute syndrome [including ST-segment elevation myocardial infarction (STEMI) and non-ST-segment (NSTEMI)] chronic (CCS).A total 163 consecutive (43 STEMI, 59 NSTEMI, 61 CCS), who underwent invasive angiography (ICA) for whom index microcirculatory resistance (IMR) was measured, were retrospectively enrolled at single center. IMR...
Retinal ischemia plays a critical role in multiple vision-threatening diseases and leads to death of retinal neurons, particularly ganglion cells. Oxidative stress an important this cell loss. Nrf2 (NF-E2-related factor 2) is major regulator the antioxidant response, its retina increasingly appreciated. We investigated potential neuroprotective function after ischemia-reperfusion (I/R) injury. In experimental model I/R, knockout mice exhibited much greater loss neuronal cells layer than...