A5101558969- Cancer-related molecular mechanisms research
- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Hypoxia, and Metabolism
- Advanced Proteomics Techniques and Applications
- Advanced Fiber Laser Technologies
- ZnO doping and properties
- Mycobacterium research and diagnosis
- Crystal Structures and Properties
- dental development and anomalies
- Protein Degradation and Inhibitors
- Proteoglycans and glycosaminoglycans research
- Photorefractive and Nonlinear Optics
- Immune cells in cancer
- Bone and Dental Protein Studies
- Prion Diseases and Protein Misfolding
- Mineralogy and Gemology Studies
- Cancer Cells and Metastasis
- Ga2O3 and related materials
- Dermatoglyphics and Human Traits
- Amyotrophic Lateral Sclerosis Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurogenetic and Muscular Disorders Research
Xidian University
2025
First Affiliated Hospital of Henan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shanghai Jiao Tong University
2009-2023
Shanghai First People's Hospital
2022-2023
Tongren Hospital
2016-2020
Ningxia Medical University
2015-2016
Second Military Medical University
2009
Abstract Dissecting the spatial heterogeneity of cancer-associated fibroblasts (CAFs) is vital for understanding tumor biology and therapeutic design. By combining pathological image analysis with proteomics, we revealed two stromal archetypes in hepatocellular carcinoma (HCC) different biological functions extracellular matrix compositions. Using paired single-cell RNA epigenomic sequencing Stereo-seq, fibroblast subsets CAF-FAP CAF-C7, whose enrichment strongly correlated opposing patient...
Identification of novel non-invasive biomarkers is critical for the early diagnosis lung adenocarcinoma (LUAD), especially accurate classification pulmonary nodule. Here, a multiplexed assay developed on an optimized nanoparticle-based laser desorption/ionization mass spectrometry platform sensitive and selective detection serum metabolic fingerprints (SMFs). Integrative SMFs based multi-modal platforms are constructed LUAD The dual modal model, with protein tumor marker neural network...
Bone metastasis is one of the main complications lung cancer and most important factors that lead to poor life quality low survival rate in patients. However, regulatory mechanisms underlying bone are still understood. Here, we report microRNA-182 (miR-182) plays a critical role regulating osteoclastic cells. We found miR-182 was significantly upregulated both bone-metastatic human non-small cell (NSCLC) line tumor specimens. further demonstrated markedly enhanced ability NSCLC cells for...
Estrogen/ERα signaling is critical for breast cancer progression and therapeutic treatments. Thus, identifying new regulators of this pathway will help to develop therapeutics overcome chemotherapy resistance the cells. Here, we report Ajuba directly interacts with ERα potentiate target gene expression, biologically promotes cell growth contributes tamoxifen these constitutively binds DBD AF2 regions ERα, interactions can be markedly enhanced by estrogen treatment. Mechanistically, recruits...
// Chao Liu 1, 2, * , Jiamin Wang 3, 4, Xiaoyuan Yuan 4 Wenli Qian Bosen Zhang 1 Minmin Shi 2 Junjie Xie Baiyong Shen Hong Xu Zhaoyuan Hou 5 Hao Chen Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School Medicine, Shanghai, China Institute Digestive 3 Hongqiao Tongren Hospital/Faculty Basic Biochemistry and Molecular Cell Biology, Key Laboratory for Tumor Microenvironment Inflammation, Differentiation Apoptosis Chinese Minister Education, Jiao Tong These authors...
Coronary artery disease (CAD) is an enormous health problem in the world. Dermatoglyphs are cutaneous ridges on fingers, palms, and soles, formed by genetic regulation control during early intrauterine life. The Dermatoglyphic traits do not change significantly as growth of age. They may be phenotypic characters individual genes represent predisposition to certain diseases.The study was carried out document characteristic dermatoglyphic patterns coronary which could useful diagnosis...
In this paper, a promising method for growing large-sized and high-quality Mg 2 SiO 4 single crystals was explored, transparent crystal, 30 mm in diameter 80 in...
To learn more about gene editing and ALS, to provide a comprehensive view of for further treatment amyotrophic lateral sclerosis.