A5101927715- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Advanced Proteomics Techniques and Applications
- Lung Cancer Research Studies
- Educational Research and Pedagogy
- Cancer-related Molecular Pathways
- Family and Patient Care in Intensive Care Units
- Lung Cancer Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- interferon and immune responses
- Genetic factors in colorectal cancer
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Ubiquitin and proteasome pathways
- Ion-surface interactions and analysis
- Genomics and Phylogenetic Studies
- Neuroblastoma Research and Treatments
- Advanced biosensing and bioanalysis techniques
- COVID-19 and Mental Health
- Innovative Educational Techniques
- Atherosclerosis and Cardiovascular Diseases
- Attachment and Relationship Dynamics
Harbin Medical University
2021-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2017-2024
Shanghai Institute of Hematology
2024
Hebei Medical University
2022
Third Hospital of Hebei Medical University
2022
Shanghai Chest Hospital
2017-2020
Shanghai Ninth People's Hospital
2018-2019
Tianjin Medical University Cancer Institute and Hospital
2017
Abstract Early cancer detection greatly increases the chances for successful treatment, but available diagnostics some tumours, including lung adenocarcinoma (LA), are limited. An ideal early-stage diagnosis of LA large-scale clinical use must address quick detection, low invasiveness, and high performance. Here, we conduct machine learning serum metabolic patterns to detect LA. We extract direct by optimized ferric particle-assisted laser desorption/ionization mass spectrometry within 1 s...
Identification of novel non-invasive biomarkers is critical for the early diagnosis lung adenocarcinoma (LUAD), especially accurate classification pulmonary nodule. Here, a multiplexed assay developed on an optimized nanoparticle-based laser desorption/ionization mass spectrometry platform sensitive and selective detection serum metabolic fingerprints (SMFs). Integrative SMFs based multi-modal platforms are constructed LUAD The dual modal model, with protein tumor marker neural network...
Purpose: The clinical utility of cell-free DNA (cfDNA) to assess EGFR mutations is increasing. However, there are limited studies determining their validity and utility. value cfDNA assays in cancer management remains controversial. Methods: In this study, we first evaluated the analytical performance ddPCR Lung Assay. We next analyzed concordance results with tissue amplification refractory mutation system PCR (ARMS-PCR) plasma next-generation sequencing (NGS) genotyping. Finally, assessed...
Abstract Background The aims of the present study were to investigate incidence nurses who suffered anxiety during COVID-19 pandemic and explore how expressive suppression influences relationship between family function anxiety. Methods This used cross-sectional research simple random sampling. A total 300 questionnaires distributed 254 qualified after invalid proposed, thus a female from tertiary hospital included in this study. measurement General demographic questionnaires, Self-Scale...
Abstract High‐throughput sequencing of circulating cell‐free DNA (cfDNA) is critical for targeted therapy selection and monitoring in non‐small cell lung cancer (NSCLC) patients. However, low quantities cfDNA the blood assay artifacts limit sensitivity specificity next‐generation (NGS) test. This study develops a novel amplicon‐based NGS technology, CLAmp‐seq ( c ircular l igation mplification sequencing), with concatemer‐based error correction strategy, which effectively removes polymerase...
<title>Abstract</title> <bold>Background</bold>: The relationship between perceived stress and mobile phone addiction among nursing students requires elucidation, alongside the clarification of potential explanatory pathways for associated risks. <bold>Methods</bold>: 4179 freshmen sophomore participated in this investigation. Several assessment tools were employed, including Chinese Perceived Stress Scale, Generalized Anxiety Disorder-7 scale, Flow State Mobile Phone Addiction Tendency...
As the third generation of molecular marker, single nucleotide polymorphism (SNP) has considerable application value in many fields. It requires high-throughput, simple and precise methods for SNP detection. We demonstrated a new nucleic acids detection approach using nanoparticles as co-matrix assisted with laser desorption/ionization mass spectrometry (LDI MS). Owing to condensation metal oxide nanoparticles, we achieved uniform crystallization organic matrix. Consequently, sensitivity...
Simazine is a widely used herbicide and known as an environmental estrogen. Multiple studies have proved simazine can induced the degeneration of dopaminergic neuron resulting in degenerative disease-like syndrome. Herein, we explored neurotoxicity on nervous system embryos weaned offspring during maternal gestation period or lactation periods. We found that disturbed crucial components expression involved Lmx1a/Wnt1 pathway embryonic offspring. Furthermore, morphological behavioral tests...