A5100422786- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- Bacteriophages and microbial interactions
- X-ray Diffraction in Crystallography
- Electrochemical sensors and biosensors
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Pickering emulsions and particle stabilization
- Osteoarthritis Treatment and Mechanisms
- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Electrospun Nanofibers in Biomedical Applications
- Analytical Chemistry and Sensors
- Plant Virus Research Studies
- Nanoplatforms for cancer theranostics
- Electrochemical Analysis and Applications
- Mesenchymal stem cell research
- Microfluidic and Capillary Electrophoresis Applications
- Chemical Synthesis and Analysis
- Conducting polymers and applications
- Polymer Surface Interaction Studies
North China University of Science and Technology
2019-2025
Chinese Academy of Sciences
2016-2025
Institute of Hydrobiology
2023-2025
Jiangsu Province Hospital
2018-2025
Sichuan University
2015-2025
China Jiliang University
2012-2025
University of South Carolina
2016-2025
Xiamen University
2008-2025
Affiliated Hospital of Qingdao University
2014-2025
University of Chinese Academy of Sciences
2016-2025
The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently in aqueous solution the presence of a tris(triazolyl)amine ligand. process has been employed to make rapid reliable covalent connections micromolar concentrations protein decorated with either reactive moieties. chelating ligand plays crucial role stabilizing Cu(I) oxidation state protecting from Cu(triazole)-induced denaturation. Because azide alkyne groups themselves are unreactive residues or...
Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition this allowed us to construct a large library pure coumarin dyes. Since both azide alkyne are quite inert biological systems, has potential in bioconjugation bioimaging applications.
It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of devices, a phenomenon can be exploited for label-free detection biomolecules with high potential miniaturization. This work presents an elucidation electronic biosensing mechanisms newly developed microarray "micromat" sensors. Chemical functionalization schemes are devised block selected components devices from...
We report the fabrication of single-walled carbon nanotube (SWNT) DNA sensors and sensing mechanism. The simple generic protocol for label-free detection hybridization is demonstrated with random sequence 15mer 30mer oligonucleotides. on gold electrodes, instead SWNT sidewalls, mainly responsible acute electrical conductance change due to modulation energy level alignment between contact. This work provides concrete experimental evidence effect SWNT−DNA binding functionality, which will help...
Acid in ionic liquid was demonstrated as an efficient system for hydrolysis of lignocellulosic materials with improved total reducing sugars (TRS) yield under mild conditions. TRS yields were up to 66%, 74%, 81% and 68% corn stalk, rice straw, pine wood bagasse, respectively, C4mimCl the presence 7 wt% hydrogen chloride at 100 °C atmospheric pressure within 60 min. Different combinations between liquids, such C6mimCl, C4mimBr, AmimCl, C4mimHSO4, SbmimHSO4, acids, including sulfuric acid,...
Grow your nanochemical dendrimers! Cowpea mosaic virus (see relief image derived from the X-ray structure) can be isolated its host plant in gram quantities and participates selective chemical reactions at specific sites of icosahedrally-arrayed coat protein. Mutant structures easily engineered, propagated, to provide particles with tailored reactivities. Applications for these areas catalysis materials science conceived.
As next-generation artificial enzymes, nanozymes have shown great promise for tumor catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze hydrogen peroxide (H2O2) produce highly toxic hydroxyl radicals (•OH) kill cells. However, limited by the low affinity between with H2O2 and level of in microenvironment, peroxidase usually produced insufficient •OH cells therapeutic purposes. Herein, we present a pyrite nanozyme ultrahigh affinity, resulting 4144-...
While various monocyte chemokine systems are increased in expression osteoarthritis (OA), the hierarchy of chemokines and receptors mediating monocyte/macrophage recruitment to OA joint remains poorly defined. Here, we investigated relative contributions CCL2/CCR2 versus CCL5/CCR5 axes pathogenesis.Ccl2-, Ccr2-, Ccl5- Ccr5-deficient control mice were subjected destabilisation medial meniscus surgery induce OA. The pharmacological utility blocking signalling mouse was using bindarit, a CCL2...
Abstract Regulating the fluorescent properties of organic small molecules in a controlled and dynamic manner has been fundamental research goal. Although several strategies have exploited, realizing multi-color molecular emission from single fluorophore remains challenging. Herein, we demonstrate an emissive system by combining pyrene acylhydrazone units, which can generate switchable emissions at different assembled states. Two kinds supramolecular tools, amphiphilic self-assembly...
Another face to Janus particles: Silica nanosheets were synthesized by crushing hollow spheres formed self-assembled materialization of an amphiphilic emulsion interface. The serve as solid surfactants and can be used collecting oil or hazardous chemical spills. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset. They made available submitted the authors. Please note: publisher is responsible for...
Metal–organic framework (MOF) nanosheets are a class of two-dimensional (2D) porous and crystalline materials that hold promise for catalysis biodetection. Although 2D MOF have been utilized in vitro assays, ways engineering them into diagnostic tools live animals much less explored. In this work, series successfully engineered highly sensitive selective platform vivo monitoring heparin (Hep) activity. The iron-porphyrin derivative is selected as ligand to synthesize archetypical with...
We have discovered that magnetic Fe3O4 nanoparticles exhibit an intrinsic catalytic activity toward the electrochemical reduction of small dye molecules. Metallic nanocages, which act as efficient signal amplifiers, can be attached to surface beads further enhance signals. The Fe3O4@nanocage core-satellite hybrid show significantly more robust electrocatalytic activities than enzymatic peroxidase/H2O2 system. demonstrated these nonenzymatic nanoelectrocatalysts used signal-amplifying...
Abstract Early cancer detection greatly increases the chances for successful treatment, but available diagnostics some tumours, including lung adenocarcinoma (LA), are limited. An ideal early-stage diagnosis of LA large-scale clinical use must address quick detection, low invasiveness, and high performance. Here, we conduct machine learning serum metabolic patterns to detect LA. We extract direct by optimized ferric particle-assisted laser desorption/ionization mass spectrometry within 1 s...
Introducing new chemical reactivity into proteins in living cells would endow innovative covalent bonding ability to for research and engineering vivo. Latent bioreactive unnatural amino acids (Uaas) can be incorporated react with target natural acid residues via proximity-enabled reactivity. To expand the diversity of amenable such vivo, a functionality that is biocompatible able multiple under physiological conditions highly desirable. Here we report genetic encoding...
Abstract The development of advanced materials for information encryption with time-dependent features is essential to meet the increasing demand on security. Herein, smart orthogonal and temporal properties are successfully developed based a dynamic assembly-induced multicolour supramolecular system. Multicolour fluorescence, including blue, orange even white light emissions, achieved by controlling assembly pyrene derivatives tailoring solvent composition. By taking advantage tuneable...
Adult stem cell research has been advanced in recent years because of the cells' attractive abilities self-renewal and differentiation. Topography materials is one key features that can be harnessed to regulate behaviors. Stem cells interact with underlying material through nanosized integrin receptors. Therefore, manipulation topographical cues at a nanoscale level employed modulate fate. In this review, we focus our discussion on different surface cues, especially, an emphasis viral...
Abstract Amorphous purely organic phosphorescence materials with long‐lived and color‐tunable emission are rare. Herein, we report a concise chemical ionization strategy to endow conventional poly(4‐vinylpyridine) (PVP) derivatives ultralong (UOP) under ambient conditions. After the of 1,4‐butanesultone, resulting PVP‐S phosphor showed UOP lifetime 578.36 ms, which is 525 times longer than that PVP polymer itself. Remarkably, multicolor ranging from blue red was observed variation excitation...