A5021702791- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- S100 Proteins and Annexins
- Bioactive Natural Diterpenoids Research
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Acute Lymphoblastic Leukemia research
- Amino Acid Enzymes and Metabolism
- Pain Mechanisms and Treatments
- Biochemical and Structural Characterization
- Plant-based Medicinal Research
- Sulfur Compounds in Biology
- Pharmacological Receptor Mechanisms and Effects
- Nanoplatforms for cancer theranostics
- Asthma and respiratory diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cancer Immunotherapy and Biomarkers
- Corneal surgery and disorders
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
Capital Medical University
2021-2025
Beijing Tongren Hospital
2021-2025
Zhejiang Sci-Tech University
2014-2024
Lanzhou University
2005-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2024
Zhejiang Medical and Health Group Hangzhou Hospital
2023
Massachusetts Institute of Technology
2019
University of California, San Francisco
2018
Abstract Blockade of the protein–protein interaction between transmembrane protein programmed cell death 1 (PD‐1) and its ligand PD‐L1 has emerged as a promising immunotherapy for treating cancers. Using technology mirror‐image phage display, we developed first hydrolysis‐resistant D ‐peptide antagonists to target PD‐1/PD‐L1 pathway. The optimized compound PPA‐1 could bind at an affinity 0.51 μ M in vitro. A blockade assay cellular level tumor‐bearing mice experiments indicated that also...
Cell death is an essential biological process for physiological growth and development. Three classical forms of cell death-apoptosis, autophagy, necrosis-display distinct morphological features by activating specific signaling pathways. With recent research advances, we have started to appreciate that these processes can cross-talk through interconnecting, even overlapping, pathways, the final fate result interplay different programs. This review provides insight into independence...
Introducing new chemical reactivity into proteins in living cells would endow innovative covalent bonding ability to for research and engineering vivo. Latent bioreactive unnatural amino acids (Uaas) can be incorporated react with target natural acid residues via proximity-enabled reactivity. To expand the diversity of amenable such vivo, a functionality that is biocompatible able multiple under physiological conditions highly desirable. Here we report genetic encoding...
Substance P (SP) regulates multiple biological processes through its high-affinity neurokinin-1 receptor (NK-1R). While the SP/NK-1R signaling axis is involved in pathogenesis of solid cancer, role this pathway hematological malignancy remains unknown. Here, we demonstrate that NK-1R expression markedly elevated white blood cells from acute myeloid leukemia patients and a panel human cell lines. Blocking induces apoptosis vitro vivo via increase mitochondrial reactive oxygen species. This...
Abstract LF11-322 (PFWRIRIRR-NH 2 ) (PFR peptide), a nine amino acid-residue peptide fragment derived from human lactoferricin, possesses potent cytotoxicity against bacteria. We report here the discovery and characterization of its antitumor activity in leukemia cells. PFR inhibited proliferation MEL HL-60 cells by inducing cell death absence classical features apoptosis, including chromatin condensation, Annexin V staining, Caspase activation increase abundance pro-apoptotic proteins....
Abstract In chronic wound management, efficacious handling of exudate and bacterial infections stands as a paramount challenge. Here novel biomimetic fabric, inspired by the natural transpiration mechanisms in plants, is introduced. Uniquely, fabric combines commercial polyethylene terephthalate (PET) with asymmetrically grown 1D rutile titanium dioxide (TiO 2 ) micro/nanostructures, emulating critical plant features: hierarchically porous networks hydrophilic water conduction channels. This...
Annexin A1 is a Ca2+-dependent phospholipid binding protein involved in variety of pathophysiological processes. Accumulated evidence has indicated that important functions cell proliferation, apoptosis, differentiation, metastasis, and inflammatory response. Moreover, the abnormal expression closely related to occurrence development tumors. In this review article, we focus on structure function protein, especially recent role cancer. This summary will be very for further investigation novel...
The neurokinin-1 receptor (NK-1R) antagonists are approved as treatment for chemotherapy-associated nausea and vomiting in cancer patients. emerging role of the substance P-NK-1R system oncogenesis raises possibility repurposing well-tolerated NK-1R treatment. This study reports that human colorectal (CRC) patients with high expression have poor survival, SR140333 aprepitant induce apoptotic cell death CRC cells inhibit xenograft growth. cytotoxicity induced by is mediated induction...
Hyperactivation of oncogenic pathways downstream RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as tumor-suppressive mechanism must be overcome during transformation. We previously demonstrated AKT-induced senescence (AIS) is associated with profound transcriptional metabolic changes. Here, we demonstrate human fibroblasts undergoing AIS display upregulated cystathionine-β-synthase (CBS) expression enhanced uptake exogenous cysteine, which lead to increased...
Colon cancer is one of the most common digestive tract malignancies, having second highest mortality rate among all tumors, with a five-year survival advanced patients only 10%. Efficient, targeted drugs are still lacking in treating colon cancer, so it urgent to explore novel druggable targets. Here, we demonstrated that annexin A1 (ANXA1) was overexpressed tumors 50% patients, and ANXA1 overexpression significantly negatively correlated poor prognosis cancer. promoted abnormal...
AIM: To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis (LASIK) LASIK combined with accelerated crosslinking (LASIK Xtra). METHODS: This prospective study analyzed 52 consecutive treated Xtra 45 LASIK. Only right eyes two groups were analyzed. The uncorrected distance acuity (UDVA), keratometry values, postoperative central thickness (CCT), demarcation line depth, compensated intraocular pressure (IOPcc),...
Clostridium difficile carriage has been considered as a potential source for the deadly infection, but its role in cancer patients is still unclear. We aimed to identify clinical and immunological factors that are related C. Chinese patients. A total of 400 stool samples were collected from who received chemotherapy three hospitals eastern China. Bacterial genomic DNA was extracted two toxin genes (tcdA tcdB) detected. PCR ribotyping performed using capillary gel electrophoresis....
Acidic vesicles and organelles play fundamental roles in a broad range of cellular events such as endocytosis, lysosomal degradation, synaptic transmission, pathogen fate, drug delivery. Fluorescent reporters will be invaluable for studying these complex multifunctional systems with spatiotemporal resolution, yet common fluorescent proteins are generally nonfluorescent at acidic conditions due to the decrease anionic chromophores upon protonation, but physiological pH, creating interfering...
Abstract Protein therapeutics are increasingly used to treat various diseases, yet they often suffer from short serum half‐lives. An emerging strategy extend lifetime in vivo is attach fatty acids onto proteins increase their binding human albumin (HSA). Herein, the genetic encoding of ϵ‐ N ‐heptanoyl‐ l ‐lysine (HepoK) reported, which introduces a fatty‐acid‐containing amino acid into with exquisite site‐specificity and homogeneity, overcoming issues associated existing chemical conjugation...
AIM: To compare the effect of myopia and astigmatism correction postoperative change in higher-order aberration as results receiving small-incision lenticule extraction (SMILE) femtosecond laser-assisted situ keratomileusis (FS-LASIK). METHODS: A prospective non-randomized controlled study was conducted. The subjects are divided into two groups according to different operations received: 229 eyes 116 patients SMILE group 168 86 FS-LASIK group. All were followed up for 3mo by monitoring their...
Acute myeloid leukemia (AML) is a complex malignancy characterized by the clonal expansion of immature precursors. The standard treatment for newly diagnosed AML chemotherapy consisting cytosine arabinoside (Ara-C) and anthracyclines with disappointing clinical outcomes severe adverse effects, such as symptomatic bradycardia, neurotoxicity. Thus, it promising to treat through combination drug therapy reduce effects chemotherapeutics. In our recent published PNAS paper, we reported that NK-1R...