A5100424546- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Microbial Natural Products and Biosynthesis
- Traditional Chinese Medicine Studies
- Signaling Pathways in Disease
- Pharmacological Effects of Natural Compounds
- Chemotherapy-induced cardiotoxicity and mitigation
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Ginseng Biological Effects and Applications
- Renin-Angiotensin System Studies
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- Melanoma and MAPK Pathways
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
Beijing University of Chinese Medicine
2016-2025
Henan Provincial People's Hospital
2025
Second People’s Hospital of Huai’an
2025
Zhujiang Hospital
2008-2025
People 's Hospital of Jilin Province
2025
Xuzhou Medical College
2025
Southern Medical University
2016-2025
Yunnan University
2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2020-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of and its analogs remains limited. Here, we report multivariate-modular approach to metabolic-pathway engineering that succeeded in increasing titers taxadiene--the committed intermediate--approximately 1 gram per liter (~15,000-fold) an engineered Escherichia coli strain. Our partitioned taxadiene metabolic pathway into two modules: native upstream...
Abstract Traditional Chinese Medicine (TCM), with a history of thousands years clinical practice, is gaining more and attention application worldwide. And TCM-based new drug development, especially for the treatment complex diseases promising. However, owing to TCM’s diverse ingredients their interaction human body, it still quite difficult uncover its molecular mechanism, which greatly hinders TCM modernization internationalization. Here we developed first online Bioinformatics Analysis...
Angiotensin (Ang) II mediates pathophysiologial changes in the kidney. Ang-(1-7) by interacting with G protein-coupled receptor Mas may also have important biological activities.In this study, renal deficiency for diminished damage models of insufficiency as unilateral ureteral obstruction and ischemia/reperfusion injury while infusion to wild-type mice pronounced pathological outcome aggravating inflammatory response. inhibited NF-kappaB activation thus elevation inflammation-stimulating...
Endophytic fungi represent underexplored resource of novel lead compounds and have a capacity to produce diverse class plant secondary metabolites. Here we investigated endophytic diversity screening paclitaxel-producing from Taxus x media.Eighty-one isolated T. media were grouped into 8 genera based on the morphological molecular identification. Guignardia Colletotrichum dominant genera, whereas remaining infrequent groups. The Glomerella Gibberella first reported in Taxus. Three...
Heart failure (HF) leads to an increase in morbidity and mortality globally. Tanshinone IIA is important traditional Chinese medicine monomer has been shown have remarkable protective effect against HF. Autophagy critically involved the progression of The on autophagy not clarified yet. In this study, left anterior descending (LAD) ligation was used induce HF model a hydrogen peroxide-(H2O2-)-induced H9C2 cell injury established. vivo, echocardiography results showed that could significantly...
p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells response to environmental factors, oncogenic stress, radiation, and chemotherapy. MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), regulates the production cytokines tumor microenvironment, such as TNF-α, interleukin-1β (IL-1β), IL-6, CXCL8 (IL-8). highly expressed human cancers may play role growth, invasion, metastasis, drug resistance. LY2228820 dimesylate (hereafter LY2228820), trisubstituted...
Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C-X-C motif chemokine ligand 12 (CXCL12) its receptor, receptor 4 (CXCR4). CXCR4 antagonists mobilize cells promote infarct repair, but the cellular mechanisms are unclear. Methods: We investigated therapeutic potential mode of action peptidic macrocycle antagonist POL5551 in mice with reperfused MI....
To combat the coronavirus disease 2019 (COVID-19) pandemic, nonpharmaceutical interventions (NPIs) were implemented worldwide, which impacted a broad spectrum of acute respiratory infections (ARIs).Etiologically diagnostic data from 142 559 cases with ARIs, who tested for 8 viral pathogens (influenza virus [IFV], syncytial [RSV], human parainfluenza [HPIV], adenovirus [HAdV], metapneumovirus [HMPV], [HCoV], bocavirus [HBoV], and rhinovirus [HRV]) between 2012 2021, analyzed to assess changes...
Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application doxorubicin limited due to cumulative dose-dependent cardiotoxicity. Dihydrotanshinone I (DHT) natural product from Salvia miltiorrhiza Bunge with multiple anti-tumor activity anti-inflammation effects. However, its anti-doxorubicin-induced cardiotoxicity (DIC) effect, either vivo or vitro, has not been elucidated yet. This study aims explore the effects DHT against DIC,...
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Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF) progression. Calycosin (Cal) is the major active component of Astragalus mongholicus Bunge has reported therapeutic effects on cardiac dysfunction after myocardial infarction. However, whether Cal could ameliorate infarction (MI)-induced inflammation precise mechanisms remain uncertain. The aim this study explore role HF clarify underlying mechanisms. Methods: For vivo experiments, rats underwent left...
Coronary Artery Calcification (CAC) is a major risk factor for various cardiovascular diseases. Low-Density Lipoprotein Cholesterol (LDL-C) significant in atherosclerotic diseases and usually elevated patients with Type 2 Diabetes Mellitus (T2DM). However, the association between LDL-C levels incident CAC asymptomatic T2DM remains unclear. This study single-center retrospective cohort conducted from January 2018 to December 2023, including 2,631 who underwent regular health screenings. All...
In this paper, we present a case study of Qishenkeli (QSKL) to research TCM's underlying molecular mechanism, based on drug target prediction and analyses TCM chemical components following experimental validation. First, after determining the compositive compounds QSKL, use drugCIPHER-CS predict their potential targets. These targets are significantly enriched with known cardiovascular disease-related Then find these in biological processes neuroactive ligand-receptor interaction,...
Emerging evidence suggests that autophagy plays important roles in the pathophysiological processes of cerebral ischemia and reperfusion injury. Calycosin, an isoflavone phytoestrogen, possesses neuroprotective effects rats. Here, we investigated calycosin against injury, as well related probable mechanisms behind pathways.A ischemic injury model was established by middle artery occlusion male Sprague-Dawley Neurological scores, infarct volumes, brain water content were assessed after 24 h...
Heart failure (HF) leads to an increase in morbidity and mortality globally. Disorders of energy metabolism apoptosis cardiomyocytes are critically involved the progression HF. Ginsenoside Rb3 (G-Rb3) is a natural product derived from ginseng that has cardio-protective effect. The pharmacological mechanism G-Rb3 treatment HF remains be clarified. In this study, we aimed explore regulative effects on fatty acids oxidation by vivo vitro studies. Myocardial infarction (MI)-induced mice model...
Fibrotic scarring drives the progression of heart failure after myocardial infarction (MI). Therefore, development specific treatment regimens to counteract fibrosis is high clinical relevance. The transcription factor sex-determining region Y box 9 (SOX9) functions as an important regulator during embryogenesis, but recent data point toward additional causal role in organ fibrosis. We show here that SOX9 upregulated scar MI mice. Fibroblast-specific deletion Sox9 ameliorated MI-induced left...
Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation autophagy implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediators autophagy. In this work, by assessing autophagic flux a DOX-stimulated H9C2 model, we observed autolysosome accumulation caused interruption degradation. Tanshinone IIA (TSA) well-known small...