A5011825695- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- TGF-β signaling in diseases
- Mesenchymal stem cell research
- Stress Responses and Cortisol
- FOXO transcription factor regulation
- Tryptophan and brain disorders
- Medicinal Plant Pharmacodynamics Research
- Tracheal and airway disorders
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Parathyroid Disorders and Treatments
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Concrete Corrosion and Durability
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
First Affiliated Hospital of Gannan Medical University
2023-2025
People’s Hospital of Wenshan Prefecture
2025
Beijing University of Chinese Medicine
2012-2024
Zhejiang University
2005-2024
West Anhui University
2019-2024
Ningbo University
2023-2024
Ningbo University of Technology
2024
Ningbo First Hospital
2018-2023
Affiliated Hospital of Qingdao University
2009-2023
Affiliated Hospital of Jining Medical University
2020-2023
We recently demonstrated the utility of quantifying spontaneous pain in mice via blinded coding facial expressions. As majority preclinical research is fact performed laboratory rat, we attempted to modify scale for use this species. present herein Rat Grimace Scale, and show its reliability, accuracy, ability quantify time course intraplantar complete Freund's adjuvant, intraarticular kaolin-carrageenan, laparotomy (post-operative pain) assays. The scale's demonstrate dose-dependent...
Abstract Recent studies have shown the importance of cell–substrate interaction on neurone outgrowth, where Young’s modulus matrix plays a crucial role neurite length, migration, proliferation, and morphology neurones. In present study, PC12 cells were selected as representative to be cultured hydrogel substrates with different stiffness explore effect substrate outgrowth. By adjusting concentration gelatin methacryloyl (GelMA), variation stiffnesses (indicated by modulus) from approximately...
Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF) progression. Calycosin (Cal) is the major active component of Astragalus mongholicus Bunge has reported therapeutic effects on cardiac dysfunction after myocardial infarction. However, whether Cal could ameliorate infarction (MI)-induced inflammation precise mechanisms remain uncertain. The aim this study explore role HF clarify underlying mechanisms. Methods: For vivo experiments, rats underwent left...
Peripheral nerve injuries (PNIs) can cause neuropathies and significantly affect the patient's quality of life. Autograft transplantation is gold standard for conventional treatment; however, its application limited by unavailability, size mismatch, local tissue adhesion. Tissue engineering, such as guidance conduits, an alternative promising strategy to guide regeneration peripheral repair; only a few conduits could reach high repair efficiency autografts. The healing process PNI frequently...
BPD (bronchopulmonary dysplasia) is predominantly characterized by persistent abnormalities in lung structure and arrested development, but therapy can be palliative. While promising, the use of BMSC (bone marrow-derived mesenchymal stem cell) treatment diseases remains controversial. We have assessed therapeutic effects vitro vivo. In co-culturing with injured tissue increased migration-potential BMSC; SP-C (surfactant protein-C), a specific marker AEC2 (type II alveolar epithelial cells),...
Abstract Tubulointerstitial fibrosis (TIF) is involved in the development of diabetic kidney disease (DKD). Transforming growth factor β1 (TGF-β1) extensive renal tissue by facilitating partial epithelial-mesenchymal transition (EMT), increasing synthesis extracellular matrix (ECM), inhibiting degradation, inducing apoptosis parenchyma cells, and activating interstitial fibroblasts inflammatory cells. Recent studies indicated that bone morphogenetic protein-7 (BMP-7) upregulated expression...
Background/Aims: This study aimed to identify the role of microRNA-22 (miR-22) in endothelial cell (EC) injury coronary heart disease (CHD) by targeting NLRP3 through inflammasome signaling pathway. Methods: A total 24 healthy male Sprague-Dawley (SD) rats were divided into normal and atherosclerosis groups. The assigned blank, negative control (NC), miR-22 mimic, inhibitor + siNLRP3 luciferase reporter gene assay was used detect relationship between NLRP3. MiR-22 expression as well...
Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it tentatively attributed to the chronic cytokine-mediated inflammatory response which induced by dysregulation of HPA axis overactivation innate immunity. However, exact mechanisms remain obscure. Herein, we mainly focused on function NLRP3 inflammasome investigate this issue.Male C57BL/6 mice were subjected 12 weeks...
Cardiotoxicity is one of the main side effects doxorubicin (Dox) treatment. Dox could induce oxidative stress, leading to an opening mitochondrial permeability transition pore (mPTP) and apoptosis in cardiomyocytes. Previous studies have shown that Cryptotanshinone (Cts) has potential cardioprotective effects, but its role Dox-induced cardiotoxicity (DIC) remains unknown. A Dox-stimulated H9C2 cell model was established. The Cts on viability, reactive oxygen species (ROS), superoxide ion...
Valerenic acid (VA) is a unique and biologically active component in Valeriana officinalis L., which has been reported to have regulatory effect on the cardiovascular system. However, its therapeutic effects pathological myocardial hypertrophy (PMH) underlying mechanisms are undefined. Our study aims elucidate how VA improves PMH, preliminarily discuss mechanism. The efficacy of PMH was confirmed by vivo vitro experiments mechanism investigated molecular dynamics (MD) simulations specific...
Depression is one of the most common mental disorders characterized mainly by low mood and loss interest or pleasure. About a third patients with depression do not respond to classic antidepressant treatments. Recent evidence suggests that Mrp8/14 (myeloid-related protein 8/14) plays crucial role in cognitive dysfunction neuroinflammatory diseases, yet its regulation remains largely uninvestigated. In present work, we explored potential progression depression. After 4 weeks chronic...
Significant losses of synapses have been demonstrated in studies Alzheimer's disease (AD), but structural and functional changes that depend on alterations the postsynaptic density (PSD) area occur prior to synaptic loss play a crucial role pathology AD. Evidence suggests curcumin can ameliorate learning memory deficits To investigate effects synapses, APPswe/PS1dE9 double transgenic mice (an AD model) were used, ultra-structures synapse-associated proteins observed. Six months after...