A5022255776- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Chromatography in Natural Products
- Analytical Chemistry and Chromatography
- Bone health and osteoporosis research
- Tryptophan and brain disorders
- Plant-based Medicinal Research
- Kidney Stones and Urolithiasis Treatments
- Pharmacological Effects of Natural Compounds
- Sulfur-Based Synthesis Techniques
- Phytochemistry and Biological Activities
- Chronic Kidney Disease and Diabetes
- Berberine and alkaloids research
- Oxidative Organic Chemistry Reactions
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Bone Metabolism and Diseases
- Ginkgo biloba and Cashew Applications
- Fungal Biology and Applications
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
Wuhan University
2018-2025
Shanghai University
2018-2025
Xi'an Medical University
2025
Air Force Medical University
2021-2025
Chinese Academy of Sciences
2020-2024
Inner Mongolia Medical University
2019-2024
Xinxiang Medical University
2020-2024
Kunming Institute of Zoology
2024
Université de Toulouse
2024
Inner Mongolia Agricultural University
2022-2024
Traditional reductions of alkenes, such as using stoichiometric reductants with waste generation and catalytic hydrogenation high-pressure H2, are accompanied by environmental or safety issues. Herein, we demonstrated a universal method for the electrocatalytic deuteration alkenes modified electrodes under ambient temperature. The key M-H/M-D species alkene reduction were generated from electrolysis H2O/D2O on electrodes, which avoided usage H2 D2. Mono-, di-, tri-, tetra-substituted...
Rosmarinic acid (RA) and lithospermic B (LAB) are two typical phenolic acids with significant bioactivities that may contribute to the therapeutic effects of Salvia miltiorrhiza. Precise knowledge biosynthetic pathway leading RA LAB is a necessary prerequisite optimize production important compounds in S. In vivo isotopic labeling experiments using [ring-(13)C]-phenylalanine, combined dynamic measurements metabolite levels by UPLC/Q-TOF, were used investigate metabolic origin These data...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in world. However, current biomarkers that discriminate HCC from liver cirrhosis (LC) are important but limited. More reliable for diagnosis therefore needed. Serum patients, LC patients and healthy volunteers were analyzed using NMR LC/MS-based approach conjunction with random forest (RF) analysis to their serum metabolic profiles. Thirty-two potential have been identified, feasibility these was evaluated, where 100%...
A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp3)–C(sp3) bond cleavage C(sp3)–Cl formation efficiently occur with good yields under mild conditions, the chlorinated products are readily transformed into other useful synthetic intermediates drugs. The reaction features complete regioselectivity, high efficiency, excellent practicality.
Abstract Osteoporosis, characterized by bone mass reduction and increased fractures, has become a global health problem that seriously affects the of people, especially postmenopausal women; however, current pathogenesis osteoporosis (PMOP) not been thoroughly elucidated to date. In this study, bilateral ovariectomy was performed establish an OVX mouse model osteoporosis. UPLC-Q-TOF-MS-based lipidomics in combination with metabolomics were used analyze femur tissue mice. We found 11 polar...
Abstract Dearomative annulation of indoles has emerged as a powerful tool for the preparation polycyclic indoline‐based alkaloids. Compared with well‐established methods towards five‐membered‐ring‐fused indolines, six‐membered‐ring‐fused indolines are rarely accessed under thermal conditions. Herein, dearomative [4+2] between different is developed through an electrochemical pathway. This transformation offers remarkably regio‐ and stereoselective route to highly functionalized pyrimido[5,4‐...
Abstract High‐performance liquid chromatography‐diode array detection (HPLC‐DAD), electrospray ionization time‐of‐flight mass spectrometry (HPLC‐ESI‐TOF‐MS) and quadrupole ion trap (HPLC‐ESI‐MS n ) were used for the isolation, identification structural analysis of water‐soluble phenolic nonpolar diterpenoid constituents in Dan‐shen (Radix Salvia miltiorrhizae which was prepared by sonication 70% methanol. Mass spectra obtained ESI‐TOF‐MS (ESI‐QIT‐MS). A formula database known established...
Background In spite of great advances in target-oriented Western medicine for treating myocardial infarction (MI), it is still a leading cause death worldwide epidemic. contrast to medicine, Traditional Chinese (TCM) uses holistic and synergistic approach restore the balance Yin-Yang body energy so body's normal function can be restored. Sini decoction (SND) well-known formula TCM which has been used treat MI many years. However, its activity evaluation mechanistic understanding are lacking...
Abstract The damage-associated molecular pattern molecules (DAMPs) released by necrotic cells can trigger inflammatory response, which will facilitate the clearance of these dead cells. Neutrophil mobilization is a very important step for cell clearance, however detailed mechanisms DAMPs induce neutrophil remains largely elusive. In this study, using cell-induced mice model, we found that both number and percentage rapidly (as early as 30 min) increased with but not live treatment. CXCL1 was...
A panel of serum metabolite markers (glutamine, kynurenine, and LysoPC(18:2)) was identified as candidate diagnostic biomarkers for post-stroke cognitive impairment.
A strategy for oxidative Csp3–H/N–H cross-coupling is presented. This reaction successfully utilizes 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and tert-butyl nitrite (TBN) as co-catalysts to construct the biomedical applicable biheteroarenes under aerobic conditions. Notably, this amination successful with a wide range of alkylheteroarenes could be used functionalization tactic pharmaceutical research other areas. Furthermore, preliminary mechanistic studies indicate that C–N bond...
Postmenopausal osteoporosis is characterized by excess osteoclastogenesis which leads to net bone loss and brittle fractures.Studies have demonstrated that estrogen deficiency-associated microbiotadependent could be prevented probiotics prebiotics.In this study, we report orally administered lactulose (20 g/kg, 6 weeks) significantly inhibited osteoclastogenesis, resorption, ovariectomy (OVX)-induced in mice.Lactulose increased intestinal Claudin 2, 3 15, compared the OVX group, lowered...
With the importance of sulfur-containing organic molecules, developing methodologies toward C–S bond formation is a long-standing goal, and, to date, considerable progress has been made in this area. Recent electrochemical oxidative cross-coupling reactions for allow synthesis molecules from more effective synthetic routes with high atom economy under mild conditions. In review, we highlight vital novel research arena an emphasis on and mechanistic aspects electrochemistry reactions. 1...
Background Doxorubicin (DOX) is one of the most potent antitumor agents available; however, its clinical use limited because risk severe cardiotoxicity. Though numerous studies have ascribed DOX cardiomyopathy to specific cellular pathways, precise mechanism remains obscure. Sini decoction (SND) a well-known formula Traditional Chinese Medicine (TCM) and considered as efficient against DOX-induced cardiomyopathy. However, action mechanisms are not well known due complex components....
Isatis indigotica is a widely used herb for the clinical treatment of colds, fever, and influenza in Traditional Chinese Medicine (TCM). Various structural classes compounds have been identified as effective ingredients. However, little known at genetics level about these active metabolites. In present study, we performed de novo transcriptome sequencing first time to produce comprehensive dataset I. indigotica. A database 36,367 unigenes (average length = 1,115.67 bases) was generated by...
A molecular description of lignan biosynthesis in Isatis indigotica displaying its synthetic characteristics and regulatory mechanism is great importance for the improvement production this class active compounds. To discover potential key catalytic steps genes, I. hairy roots elicited by methyl jasmonate (MeJA) were used as a source systematic variation exploring metabolic/transcriptional changes candidate genes that might play roles biosynthesis. The reprogramming modulated MeJA was...