A5018921666- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Cholinesterase and Neurodegenerative Diseases
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Ginseng Biological Effects and Applications
- Analytical Chemistry and Chromatography
- Ginkgo biloba and Cashew Applications
- Chromatography in Natural Products
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Chemical synthesis and alkaloids
- Advanced Chemical Sensor Technologies
- Neurogenesis and neuroplasticity mechanisms
- Food Quality and Safety Studies
- EEG and Brain-Computer Interfaces
- Synthesis and biological activity
- Folate and B Vitamins Research
- Plant biochemistry and biosynthesis
- Phytoestrogen effects and research
- Berberine and alkaloids research
Liaoning University of Traditional Chinese Medicine
2020-2025
Henan University of Science and Technology
2025
RELX Group (Netherlands)
2018-2020
China Pharmaceutical University
2013-2018
A universal and promising route for screening of high-quality enzyme inhibitors from herbal medicines.
Abstract Two concepts involving natural products were proposed and demonstrated in this paper. (1) Natural product libraries (e.g. herbal extract) are not perfect for bioactivity screening because of the vast complexity compound compositions, thus a library reconstruction procedure is necessary before screening. (2) The traditional mode “screening single compound” could be improved to compound, drug combination multicomponent interaction” due fact that medicines work by integrative effects...
Restoring the compromised neurogenesis has been served as a potential strategy to rescue cognitive dysfunction of Alzheimer's disease (AD). In this study, we explored whether icarisid II (ICS II), natural product possessing powerful neuroprotection, could recover APP/PS1 mice, and investigated its underlying mechanisms. Our results showed that oral administration ICS alleviate injuries promote hippocampal neurogenesis, well stimulate Wnt/β-catenin signal pathway confirmed by upregulated...
ABSTRACT Introduction Berberis fortunei Lindl. (BF) is a medicinal plant widely utilized in East Asia. However, the chemical components present its roots, stems, and leaves have not been systematically analyzed compared. The specific active ingredients that inhibit HT29 colorectal cancer cells are still unclear. Objective aim of this study to comprehensively analyze compositions BF's evaluate their biological function against cells. Methodology GC‐IMS LC‐QTOF‐MS were employed volatile...
The similarity in appearance of poisonous and medicinal plants, such as Asarum heterotropoides (AH) Cynanchum paniculatum (CP), poses safety risks due to frequent confusion. Since AH contains toxic ingredients, the traditional methods olfactory gustatory identification cannot be used distinguish from CP. To differentiate them systematically, we proposed a novel strategy based on dual electronic sensors (DES) fingerprint spectra (DFS). DES included two intelligent sensors, namely E-nose...
Epilepsy is one of the most common cerebral diseases, development which can be divided into four states: interictal state, preictal ictal state and postictal state. Hunting for critical states great significance to predict seizures. This study seeks establish a general-purpose method epileptic seizure prediction by constructing individual-specific correlation networks between multi-channel EEG signals. In this paper, we present mobile network information gain (M-NIG) transforming floating...
Ultrafiltration LC-MS, affinity-guided isolation and molecular docking were integrated into one strategy to discover bioactive compounds from functional foods.
Zanthoxyli radix is a popular tea among the elderly, and it believed to have positive effect on Alzheimer's disease. In this study, highly effective three-step strategy was proposed for comprehensive analysis of active components biological functions Zanthoxylum nitidum (ZN), including high-resolution LC-Q-TOF mass spectrometry (HRMS), multivariate statistical heterogeneity (MSAH), experimental virtual screening bioactivity (EVBA). A total 117 compounds were identified from root, stem, leaf...
Herbal medicines (HMs) are an important source of drugs. In this study, efficient strategy integrating ultrafiltration LC-MS, microplate bioassays, and molecular docking was proposed to screen high-potency enzyme inhibitors from HMs. Using strategy, the structure-activity relationships (SARs) including binding-affinity-based SAR, enzymatic-activity-based structural-complementarity-based SAR compounds in HM can be analyzed provide abundant information for drug discovery. A prominent advantage...