A5100368060- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Analytical chemistry methods development
- Phytochemicals and Antioxidant Activities
- Mass Spectrometry Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Tea Polyphenols and Effects
- Drug Transport and Resistance Mechanisms
- Berberine and alkaloids research
- Retinal Diseases and Treatments
- Nutrition and Health in Aging
- Plant-based Medicinal Research
- Allergic Rhinitis and Sensitization
- Traditional Chinese Medicine Analysis
- Antimicrobial Peptides and Activities
- Advanced Chemical Sensor Technologies
- Probiotics and Fermented Foods
- Plant Toxicity and Pharmacological Properties
- Glaucoma and retinal disorders
- Advanced Proteomics Techniques and Applications
- Phytochemistry and Biological Activities
Shandong First Medical University
2017-2025
Guiyang Medical University
2020-2025
Macau University of Science and Technology
2016-2025
Inner Mongolia University
2025
Tsinghua University
2006-2025
Kunming University of Science and Technology
2023-2025
Kunming Medical University
2012-2025
Shandong University of Traditional Chinese Medicine
2023-2025
Affiliated Hospital of Guizhou Medical University
2022-2025
Chinese University of Hong Kong
2009-2025
Abstract Environmental factors may influence types and contents of active substances. This study investigated the environmental on substance antioxidant activity Potentilla fruticosa L. from different regions China. Also, HPLC fingerprint similarity analysis (SA) coupled with hierarchical cluster (HCA) discriminant (DA) were further introduced for accurate classification quality assessment P. . The results showed that altitude was significantly negatively correlated to content tannin ( P...
Cycads represent one of the most ancient lineages living seed plants. Identifying genomic features uniquely shared by cycads and other extant plants, but not non-seed-producing may shed light on origin key innovations, as well early diversification Here, we report 10.5-Gb reference genome Cycas panzhihuaensis, complemented transcriptomes 339 cycad species. Nuclear plastid phylogenomic analyses strongly suggest that Ginkgo form a clade sister to all gymnosperms, in contrast mitochondrial...
Abstract Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactylation novel lactate-derived posttranslational modification that plays key roles multiple cellular processes. Since hypoxia ischemic retinopathy precipitating factor for retinal neovascularization, lactylation very likely to be involved this process. The present study...
Uveitis causes blindness and critical visual impairment in people of all ages, retinal microglia participate uveitis progression. Unfortunately, effective treatment is deficient. Icariin (ICA) a bioactive monomer derived from Epimedium. However, the role ICA remains elusive. Our study indicated that alleviated intraocular inflammation vivo. Further results showed proinflammatory M1 could be transferred to anti-inflammatory M2 by retina HMC3 cells. direct pharmacological target unknown, this...
polysaccharide (GLP) is a prebiotic with immunomodulatory effects. However, the therapeutic potential of GLP in tumor immunotherapy has not been fully explored, especially T cell-mediated antitumor immunity. In this study, we found that significantly inhibited growth and activated immunity colorectal cancer (CRC). spleens tissues, proportion cytotoxic CD8
The cellular and subcellular localization mechanism of transport the heteromeric organic solute transporter (OST) OSTalpha-OSTbeta was examined in human rodent epithelia. two subunits were expressed together small intestine, kidney, liver, tissues that also express apical sodium-dependent bile acid uptake ASBT (SLC10A2). Indirect immunofluorescence microscopy localized OSTalpha OSTbeta to basolateral membrane mouse, rat, ileal enterocytes, renal proximal tubular cells, cholangiocytes....
Peptidic mimics of the gut hormone glucagon-like peptide (GLP) 1, exemplified by recently approved drug exenatide, show promise as therapies for type 2 diabetes. Such "incretin mimetics" regulate glucose appearance in plasma and can restore glucose-stimulated insulin secretion without excess risk hypoglycemia. The need injection, which may limit use peptidic GLP-1 receptor (GLP-1R) agonists, has driven largely unsuccessful efforts to find smaller molecules. failure identify orally effective...
Flavonoids are common dietary components with many health benefits shown through epidemiological studies. However, the fact that flavonoids also act as pro-oxidants and mutagens makes safety of uncertain when used at higher doses. To give a preliminary evaluation on correlation between beneficial harmful effects flavonoids, antioxidative activity cytotoxicity 20 from food herbs were investigated in vitro. The results indicated luteolin, hydroxygenkwanin, kaempferol possessed significant dual...
The CFCS of <italic>Lactobacilli</italic> strains from human breast milk induced apoptosis in HeLa cells ROS related mitochondrial pathway.
Mitochondrial fragmentation plays an important role in the progression of cardiac diseases, such as myocardial infarction and heart failure. network is controlled by many factors different cell types. Here we show that interplay between E2F1, miR-421 Pink1 regulates mitochondrial morphology cardiomyocyte death. reduces protects from apoptosis. On other hand, promotes fragmentation, apoptosis suppressing translation. Finally, transcription factor E2F1 activates expression. Knocking down...
The jasmonic acid (JA) and salicylic (SA) signalling pathways, which mediate induced plant defence responses, can express negative crosstalk. Limited knowledge is available on the effects of this crosstalk host-plant selection behaviour herbivores. We report temporal dosage such host preference oviposition-site herbivorous spider mite Tetranychus urticae towards Lima bean (Phaseolus lunatus) plants, including underlying mechanisms. Behavioural observations reveal a dynamic response mites to...