A5100454141- Spinal Cord Injury Research
- Spine and Intervertebral Disc Pathology
- Genetic factors in colorectal cancer
- Nerve Injury and Rehabilitation
- Spinal Dysraphism and Malformations
- Trauma Management and Diagnosis
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Spinal Fractures and Fixation Techniques
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver physiology and pathology
- Tea Polyphenols and Effects
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cervical and Thoracic Myelopathy
- Helicobacter pylori-related gastroenterology studies
First Affiliated Hospital of Xi'an Jiaotong University
2014-2025
Huashan Hospital
2016-2025
Southern University of Science and Technology
2025
Xinxiang Medical University
2025
Beijing Technology and Business University
2025
China Medical University
2025
Huazhong University of Science and Technology
2025
International Collaboration On Repair Discoveries
2011-2024
Dazhou Central Hospital
2024
University of British Columbia
2009-2024
Minocycline has been demonstrated to be neuroprotective after spinal cord injury (SCI). However, the cellular consequences of minocycline treatment on secondary response are poorly understood. We examined ability reduce oligodendrocyte apoptosis, microglial/macrophage activation, corticospinal tract (CST) dieback, and lesion size improve functional outcome SCI. Adult rats were subjected a C7-C8 dorsal column transection, presence apoptotic oligodendrocytes was assessed within ascending...
Phosphoenolpyruvate carboxykinase 1 (PEPCK1) is the critical enzyme for gluconeogenesis and linked with type II diabetes. Previous studies have found that SIRT2, a deacetylase, plays an important role in deacetylating PEPCK1 little known about anti-diabetic activity of SIRT2 inhibitors. In this study, we investigated effects sirtinol, inhibitor, on cell vivo vitro. Immunoblotting analysis revealed sirtinol significantly decreased protein level PEPCK1, was accompanied by hyperacetylation as...
Helicobacter pylori infection is mostly a family-based infectious disease. To facilitate its prevention and management, national consensus meeting was held to review current evidence propose strategies for population-wide H. control management reduce the related disease burden.Fifty-seven experts from 41 major universities institutions in 20 provinces/regions of mainland China were invited modify statements using Delphi process grading recommendations assessment, development evaluation...
polysaccharide (GLP) is a prebiotic with immunomodulatory effects. However, the therapeutic potential of GLP in tumor immunotherapy has not been fully explored, especially T cell-mediated antitumor immunity. In this study, we found that significantly inhibited growth and activated immunity colorectal cancer (CRC). spleens tissues, proportion cytotoxic CD8
Object In experimental models of spinal cord injury (SCI) researchers have typically focused on contusion and transection injuries. Clinically, however, other mechanisms such as fracture–dislocation distraction also frequently occur. The objective the present study was to compare primary damage in three clinically relevant animal SCI. Methods Contusion, fracture–dislocation, flexion–distraction SCI were developed. To visualize traumatic increases cellular membrane permeability,...
Chronic gastritis is one of the most common findings at upper endoscopy in general population, and chronic atrophic epidemiologically associated with occurrence gastric cancer. However, current status diagnosis treatment China unclear. A multi-center national study was performed; all patients who underwent diagnostic for evaluation gastrointestinal symptoms from 33 centers were enrolled. Data including sex, age, endoscopic prospectively recorded. Totally 8892 included. At endoscopy, 4389,...
Spontaneous remyelination occurs after spinal cord injury (SCI), but the extent of myelin repair and identity cells responsible remain incompletely understood contentious. We assessed cellular origin new by fate mapping platelet-derived growth factor receptor α (PDGFRα), Olig2+, P0+ following contusion SCI in mice. Oligodendrocyte precursor (OPCs; PDGFRα+) produced oligodendrocytes for <i>de novo</i> ensheathment ∼30% myelinated axons at epicenter 3 months SCI, demonstrating that these...
Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination contusive SCI by deleting gene from platelet-derived growth receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) mice prior to SCI. While OPC proliferation and density are not altered Myrf inducible knockout SCI, accumulation new oligodendrocytes largely prevented. This greatly inhibits...
Abstract Liver fibrosis is a wound‐healing response represented by excessive extracellular matrix deposition. Activation of hepatic stellate cell (HSC) the critical cellular basis for fibrogenesis, whereas hepatocyte undergoes epithelial‐mesenchymal transition (EMT) which also involved in chronic liver injury. Long noncoding RNA H19 has been found to be associated with cholestatic lately. However, role remains largely elucidated. In this study, we that expression was significantly...
The alteration of the enteric nervous system (ENS) and its role in neuroimmune modulation remain obscure pathogenesis inflammatory bowel diseases (IBDs). Here, by using xCell tool latest immunolabeling-enabled three-dimensional (3D) imaging solvent-cleared organs technique, we found severe pathological damage entire ENS decreased expression choline acetyltransferase (ChAT) IBD patients. As a result, acetylcholine (ACh), major neurotransmitter synthesized ChAT, was greatly reduced colon...
Abstract Whether amino acids act on cellular insulin signaling remains unclear, given that increased circulating acid levels are associated with the onset of type 2 diabetes (T2D). Here, we report phenylalanine modifies receptor beta (IRβ) and inactivates glucose uptake. Mice fed phenylalanine-rich chow or phenylalanine-producing aspartame overexpressing human phenylalanyl-tRNA synthetase (hFARS) develop resistance T2D symptoms. Mechanistically, FARS phenylalanylate lysine 1057/1079 IRβ...
The effect of tea polyphenols (TPLs), specifically catechins, on the postprandial glycemic response to cooked starches differing in amylose contents was investigated. vivo test using a mouse model showed moderate reduction co-cooked normal (containing 27.8% amylose) or waxy corn starch with 10% TPLs (dry weight starch), while an augmented delayed blood glucose peak observed when high (HAC, containing 79.4% used as component. Enzyme kinetics results demonstrated that noncompetitively inhibit...
Study Design: This is a prospective single-center nonrandomized control clinical study involving 81 overweight or obese patients who underwent minimally invasive open transforaminal lumbar interbody fusion (TLIF). Objective: The objective of this was to evaluate the safety and efficacy TLIF as an alternative technique in patients. Summary Background Data: Spinal surgery associated with increased complications, blood loss, operative times. potential benefits have been discussed few studies....
LKB1, also known as STK11, is a master kinase that serves an energy metabolic sensor and involved in cell polarity regulation. Recent studies have indicated LKB1 related to breast tumorigenesis cancer progression. However, little work has been done on the roles of epithelial-mesenchymal transition cancer. In this study, we tried prove loss disrupts epithelial causes tumor metastasis invasion.The relationships expression clinic-pathological parameters markers E-cadherin high-molecular-weight...
Trace amines (TAs) are metabolically related to catecholamine and associated with cancer neurological disorders. Comprehensive measurement of TAs is essential for understanding pathological processes providing proper drug intervention. However, the trace amounts chemical instability challenge quantification. Here, diisopropyl phosphite coupled chip two-dimensional (2D) liquid chromatography tandem triple-quadrupole mass spectrometry (LC-QQQ/MS) was developed simultaneously determine...
The objective of this study was to compare the long-term histological and behavioral outcomes after spinal cord injury (SCI) induced by one three distinct biomechanical mechanisms: dislocation, contusion, distraction. Thirty male Sprague-Dawley rats were randomized incur a traumatic cervical SCI these clinically relevant mechanisms. injured spines surgically stabilized, motor function assessed for following 8 weeks. cords then harvested histologic analysis. Quantification white matter...