A5013806203- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Plant Molecular Biology Research
- Age of Information Optimization
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Respiratory Support and Mechanisms
- Digestive system and related health
- Gastrointestinal motility and disorders
- Asthma and respiratory diseases
- Chinese history and philosophy
- CAR-T cell therapy research
- Vietnamese History and Culture Studies
- Liver Diseases and Immunity
- Wireless Communication Networks Research
Fudan University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2014-2025
Sun Yat-sen University
2025
Peking University
2015-2025
China Telecom
2023-2024
Oil Crops Research Institute
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Chinese Academy of Agricultural Sciences
2024
China Telecom (China)
2023-2024
Beta-diversity is a fundamental ecological metric for exploring dissimilarities between microbial communities. On the functional dimension, metaproteomics data can be used to quantify beta-diversity understand how community profiles vary under different environmental conditions. Conventional approaches metaproteomic often treat protein functions as independent features, ignoring evolutionary relationships among taxa from which proteins originate. A more informative distance that incorporates...
Abstract Using TLR agonists in cancer treatment can have either beneficial or detrimental effects. Therefore, it is important to determine their effect on the tumor growth and understand underlying mechanisms animal models. In this study, we report a general immunotherapeutic activity of synthetic bacterial lipoprotein (BLP), TLR1/TLR2 agonist, established lung carcinoma, leukemia, melanoma mice. Systemic 3LL tumor-bearing mice with BLP, but not LPS, led dose-dependent regression...
Gliomas, the most common primary neoplasms in brain, are notorious for their ability to evade immune response. Despite microglial infiltration gliomas, expression of MHC class II molecules those microglia is compromised. Here, we report that Toll-like receptor 2 (TLR2) activation downregulated an orthotopic murine glioma model. TLR2-induced impairment hindered proliferation and CD4+ T cells, which facilitated evasion. downregulation was caused by suppression master regulator molecule...
Tertiary lymphoid structures (TLS) in the tumor microenvironment (TME) are emerging solid-tumor indicators of prognosis and response to immunotherapy. Considering that tumorigenesis requires metabolic reprogramming subsequent TME remodeling, discovery TLS regulators is expected produce immunotherapeutic targets. To identify such regulators, we constructed a metabolism-focused sgRNA library performed an vivo CRISPR screening orthotopic lung mouse model. Combined with The Cancer Genome Atlas...
Increasing evidence in recent years has suggested that B cells act as a crucial regulator autoimmune diseases. However, little is known about their role hepatitis (AIH) and the underlying regulatory mechanisms. In this study, we show ameliorated experimental AIH (EAH) by suppressing CD4+ T-cell responses CD11b expression on was required for function of cells. vitro studies reveal suppressive mediated impairment antigen receptor (TCR) signaling transduction promotion TCR down-regulation....
IL-10-producing regulatory B cells (IL-10 + cells), a dominant cell (Breg) subset, foster tumor progression. However, the mechanisms underlying their generation in HCC are poorly understood. Ten-eleven translocation-2 (TET2), predominant epigenetic enzyme cells, regulates gene expression by catalyzing demethylation of 5-methylcytosine into 5-hydroxymethyl cytosine (5hmC). In this study, we investigated role TET2 IL-10 and its prospects for clinical application.TET2 activation triggered...
IL-10-producing B cells (B10 cells) have been shown to play a suppressive role in the peripheral blood of humans, with their numbers and function altered several autoimmune diseases. However, B10 Graves' disease (GD) remains unknown. In this study, we demonstrated that human belonged CD24hiCD27+ cell subpopulation. The proportion along CD19+CD24hiCD27+ subset was significantly lower new-onset patients compared healthy individuals. recovered patients, these proportions were restored levels...
Concanavalin A (Con A)-induced hepatitis is thought to be a T-cell-mediated disease with active destruction of liver cells. Interleukin (IL)-17 cytokine produced principally by CD4(+) T However, whether IL-17/IL-17 receptor (IL-17/IL-17R)-mediated responses are involved in Con A-induced injury remains unclear. In this study, we found that IL-17 expression was highly elevated tissues during hepatitis. The increased levels were paralleled the severity reflected Alanine aminotransaminase and...
Recent study has demonstrated that CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) present in bronchoalveolar lavage fluid (BALF) contribute to the resolution of an experimental acute lung injury (ALI). However, molecular mechanism underlying alveolar recruitment Treg remains unclear.To determine role BLT1, a chemotactic receptor for leukotriene B4 (LTB4), BALF LPS-induced ALI.We examined BLT1 expression mouse and human Tregs evaluated its mediating migration vitro vivo.We found was...
Parkinson’s disease (PD) is the fastest-growing neurodegeneration disease, characterized typically by a progressive loss of dopaminergic neurons in substantia nigra, and there are no effective therapeutic agents to cure PD. Rotenone (Rot) common widely used pesticide which can directly inhibit mitochondrial complex I, leading neurons. Our previous studies proved that JWA gene (arl6ip5) may play prominent role resisting aging, oxidative stress inflammation, knockout astrocytes increases...
Background Fasting-mimicking diet (FMD) boosts the antitumour immune response in patients with colorectal cancer (CRC). The gut microbiota is a key host immunity regulator, affecting physiological homeostasis and disease pathogenesis. Objective We aimed to investigate how FMD protects against CRC via modulation. Design assessed probiotic species enrichment FMD-treated mice using faecal metagenomic sequencing. candidate were verified antibiotic-treated conventional germ-free mouse models....
Therapeutic compounds significantly alter the composition of gut microbiota, yet their functional and ecological impacts, particularly at protein level, remain largely unexplored. In this study, we systematically mapped metaproteomic responses ex vivo human microbiota to 312 compounds, generating 4.6 million microbial responses, available as an interactive resource (https://shiny.imetalab.ca/MPR_Viz/). Across protein-level, taxonomic composition-level, ecosystem-level analyses,...
Abstract Background Psychiatric diseases seriously affect the cognitive, emotional and social functions of patients. Traditional treatment methods such as drug therapy psychotherapy have been effective in improving symptoms patients, but there are still limitations. In recent years, art has attracted more attention. Film television animation, an form with rich expression appeal, gradually recognized for its potential value regulation cognitive guidance. view limitations systematic...
Abstract Background Schizophrenia significantly impairs patients’ social functioning, including interaction, work ability, and daily living skills. Among these, the damage to functioning is a crucial barrier in recovery process of patients with schizophrenia. In recent years, Digital Media Art (DMA) has been introduced as an innovative therapeutic approach for Therefore, this study aims clarify impact DMA on chronic Methods The included 100 patients, aged 25 60, diagnosed schizophrenia,...
Strategies for preventing high glycolysis in tumour cells are urgently needed. CircRNAs (circRNAs) play important roles glycolysis. However, the mechanism underlying effects of hsa_circ_0001756 gastric cancer (GC) remains unclear. In this study, we detected expression GC tissues and using quantitative real-time polymerase chain reaction (qRT PCR). Construct a silencing overexpression vector to validate role GC. Pulldown RIP experiments were conducted verify identification miRNA protein...
CircRNAs are closely related to ferroptosis in gastric cancer cells; however, the mechanism by which circRNAs regulate carcinogenesis remains unknown. CircRNA-encoded novel peptides functional products translated from open reading frames (ORFs) within circular RNAs, demonstrating that not only serve as non-coding regulators but also have capacity encode biologically active peptides. Compared with noncancerous cells, cells greater iron requirements, and occurs response radiotherapy,...