A5100678438- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Wnt/β-catenin signaling in development and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Colorectal Cancer Treatments and Studies
- Single-cell and spatial transcriptomics
Fudan University
2007-2024
Zhongshan Hospital
2007-2024
The First Affiliated Hospital, Sun Yat-sen University
2007-2024
Sun Yat-sen University
2007-2024
Wenzhou Medical University
2023
Fujian Agriculture and Forestry University
2023
Australian Regenerative Medicine Institute
2022
Anhui Medical University
2013-2022
Jiangsu Vocational College of Medicine
2022
Monash University
2022
The overall response rate for anti-PD-1 therapy remains modest in hepatocellular carcinoma (HCC). We found that a combination of IFNα and anti-PD-1-based immunotherapy resulted enhanced antitumor activity patients with unresectable HCC. In both immunocompetent orthotopic spontaneous HCC models, synergized the treatment led to significant enrichment cytotoxic CD27+CD8+ T cells. Mechanistically, suppressed HIF1α signaling by inhibiting FosB transcription cells, resulting reduced glucose...
IL-10-producing regulatory B cells (IL-10 + cells), a dominant cell (Breg) subset, foster tumor progression. However, the mechanisms underlying their generation in HCC are poorly understood. Ten-eleven translocation-2 (TET2), predominant epigenetic enzyme cells, regulates gene expression by catalyzing demethylation of 5-methylcytosine into 5-hydroxymethyl cytosine (5hmC). In this study, we investigated role TET2 IL-10 and its prospects for clinical application.TET2 activation triggered...
Abstract Background Chromobox Homolog 1 (CBX1) plays a crucial role in the pathogenesis of numerous diseases, including evolution and advancement diverse cancers. The CBX1 pan-cancer its mechanism hepatocellular carcinoma (HCC), however, remains to be further investigated. Methods Bioinformatics approaches were harnessed scrutinize CBX1’s expression profile, association with tumor staging, potential impact on patient outcomes across various Single-cell RNA sequencing data facilitated...
Abstract Liver transplantation (LT) is one of the best therapeutic options for nonresectable hepatocellular carcinoma (HCC). Unfortunately, some HCC patients succumb to disease after LT, which reduces long- and medium-term survival. To identify proteins associated with invasion metastasis, undergoing LT complete follow-up data were included in this study categorized into recurrence nonrecurrence groups. We extracted total protein from acquired homogeneous tumor cells applied a cleavable...
Abstract Lysine acetylation (Kac) as an important posttranslational modification of histones is essential for the regulation gene expression in hepatocellular carcinoma (HCC). However, atlas whole acetylated proteins HCC tissues and difference protein between normal human are unknown. In this report, we characterized proteome acetyl (acetylome) profile normal, paracancerous, liver clinical samples by quantitative proteomics techniques. We identified 6781 sites 2582 quantified 2492 1190...
Abstract Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity heterogeneity among PLCs remains challenging. Here, using single-cell RNA sequencing, spatial transcriptomic bulk multi-omics, we elaborated molecular architecture 3 PLC types, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) combined hepatocellular-cholangiocarcinoma (CHC). Taking high-resolution...
Abstract Anti-PD-L1-based combination immunotherapy has become the first-line treatment for unresectable hepatocellular carcinoma (HCC). However, objective response rate is lower than 40%, highlighting need to identify mechanisms of tolerance immune checkpoint inhibitors and accurate biomarkers response. Here, we employed next-generation sequencing analyze HCC samples from 10 patients receiving anti-PD-L1 therapy. Activation renin-angiotensin system was elevated in nonresponders compared...
<p>Supplementary materials and methods, Supplementary Figures figure legends, Tables</p>
<div>Abstract<p>Anti–PD-L1–based combination immunotherapy has become the first-line treatment for unresectable hepatocellular carcinoma (HCC). However, objective response rate is lower than 40%, highlighting need to identify mechanisms of tolerance immune checkpoint inhibitors and accurate biomarkers response. In this study, we used next-generation sequencing analyze HCC samples from 10 patients receiving anti–PD-L1 therapy. Activation renin–angiotensin system was elevated in...
Abstract Circular RNAs (circRNAs) are a class of regulatory with complex roles in healthy and diseased tissues. However, the oncogenic role circRNAs hepatocellular carcinoma (HCC) remains poorly understood, including mechanisms by which circular ubiquitin-binding associated protein 2 (circUBAP2) contributes to tumorigenesis. We analyzed expression circUBAP2 20 paired samples HCC tissue as well seven cell lines via quantitative real-time polymerase chain reaction. Functional experiments, such...
Development of an effective antitumor immune response depends on the appropriate interaction effector and target cells. Thus, expression chemokines within tumor may induce a more potent response. Secondary lymphoid tissue chemokine (SLC) is known to play critical role in establishing functional microenvironment secondary tissues. Its capacity attract dendritic cells (DCs) colocalize them with T makes it good therapeutic candidate against cancer. In this study, we used SLC as treatment for...
Liver cancer is a lethal disease that associated with poor prognosis. In order to identify the functionally important genes liver may reveal novel therapeutic avenues, we performed integrated analysis profile miRNA and mRNA expression levels for tumors compared normal samples in The Cancer Genome Atlas (TCGA) database. We identified 405 differentially expressed 233 miRNAs tumor controls. addition, also pathway found mitogen-activated protein kinases (MAPKs) G-protein coupled receptor (GPCR)...
e16220 Background: The combination of Sintilimab (a PD-1 antibody) and bevacizumab (bev) biosimilar improved progression-free survival overall in unresectable or advanced HCC as compared with sorafenib ORIENT-32 study was approved first-line treatment for China. We assessed the efficacy safety therapy conversion potentially resectable intermediate-stage HCC. Methods: Treatment-naïve patients (pts) intermediate stage (BCLC B) were enrolled this phase II trial (NCT04843943). Eligible pts...
Abstract Dysregulation of wingless‐type (Wnt) signaling is implicated in hepatocellular carcinoma (HCC). Wnt family member 8B (Wnt8B), one the canonical ligands, oncogenesis. However, role Wnt8B human HCCs and its transcriptional regulation mechanism are presently unknown . Here, we report that expression was frequently increased significantly associated with poorer patient prognosis. knockdown suppresses HCC cell growth both vitro vivo via inhibiting signaling. Zinc finger transcription...
Abstract Background Alteration of DNA methylation is an important event in pathogenesis and progression hepatocellular carcinoma (HCC). methyltransferase (DNMT) 1, the foremost contributor machinery, was revealed elevated HCC significantly correlates with poor prognosis. However, transcriptional regulation DNMT1 remains unknown. Methods Real‐time PCR immunohistochemistry were performed to detect zinc finger transcription factor 191 (ZNF191) expressions HCCs. Transcription activity promoter...
Myeloid cells are physiologically related to innate immunity and inflammation. Tumor-associated myeloid gained increasing interest because of their critical roles in tumor progression anticancer immune responses human malignancies. However, the associations between tumor-associated cell-related genes hepatocellular carcinoma have yet be revealed. Here, through integrating analysis bulk single-cell RNA (scRNA) sequencing public HCC samples, we developed a gene signature investigate role...
Rationale: Mitochondria generate ATP via the oxidative phosphorylation system, which mainly comprises five respiratory complexes found in inner mitochondrial membrane.A high-order assembly of is called a supercomplex.COX7A2L supercomplex factor that has been well-investigated for studying function and assembly.To date, effects supercomplexes on cell metabolism have not elucidated.Methods: We depleted COX7A2L or Cox7a2l human mouse cells to models lacking as well DBA/2J mice animal models.We...
The fall armyworm, Spodoptera frugiperda, is one of the most dangerous pests to various crops. As crucial sugar crop, sugarcane also constantly threatened by these pests. Plant wound-induced proteinase inhibitors (WIP) are natural defense proteins that play important roles in system against insect attack. Breeding for resistance would be best way improve variety characteristics and productivity sugarcane. Screening verification potential plant endogenous insect-resistant genes greatly...
Abstract Background We evaluated organ-specific response rates (OSRRs) to first-line lenvatinib plus anti-PD-1 antibodies in patients with advanced hepatocellular carcinoma (HCC). Methods This retrospective analysis included Chinese unresectable/advanced HCC who received (8 mg/day) ≥3 infusions of between October 2018 and May 2020. Tumor macrovascular tumor thrombi (MVTT) treatment responses were every 2 months using RECIST v1.1. The overall rate (ORR)/OSRR was defined as the percentage a...