Abstract Background Statistical data on the incidence, mortality, and burden of breast cancer relevant risk factors are valuable for policy-making. We aimed to estimate deaths, disability-adjusted life years (DALYs) by country, gender, age group, social-demographic status between 1990 2017. Methods extracted from 2017 Global Burden Disease (GBD) study through in 195 countries territories. Data about number incident cases, DALYs, age-standardized rates were collected. also estimated...

MicroRNAs are stable and easy to detect in plasma. The plasma levels of microRNAs often changed disease conditions, including cancer. This makes circulating a novel class biomarkers for cancer diagnosis. Analyses online microRNA data base revealed that expression level three microRNAs, microRNA-24 (miR-24), microRNA-320a (miR-320a), microRNA-423-5p (miR-423-5p) were down-regulated colorectal (CRC). However, whether the these can serve as CRC diagnosis prognosis is not determined.Plasma...

Abstract Background Hodgkin lymphoma (HL) is an uncommon B cell lymphoma. We assessed the global, regional, and national burden of HL from 1990 to 2017, by gender, age, social-demographic index (SDI). Methods Data on HL, including incidence, mortality, disability adjusted life-years (DALY), 2017 were obtained Global Burden Disease study. Estimated annual percentage changes (EAPCs) calculated assess incidence rate, DALY trends. Results incidences increased 38.66%, 72,937 in 101,133 while...

Background The patterns of the incidence and mortality prostate cancer (PC) have been changing over years. In addition, unclear etiology PC necessitates further studies into geographic distribution age composition patients with PC. This study was aimed at examining epidemiology to help policymakers allocate limited resources health care system accordingly. Methods Annual case data age‐standardized rates (ASRs) were obtained for incidence, mortality, disability‐adjusted life‐years (DALYs)...

This study aimed to investigate the mechanism of probiotic VSL#3 in acute alcoholic intestinal injury, and evaluate effect VSL#3, glutamine,VSL#3+glutamine heat-killed therapy a rat model.Six- eight-week-old male wild-type rats were divided into seven groups. To establish alcohol liver disease model, received three doses corn starch dissolved PBS/40% administered intra-gastrically every 12 hours. Treatment groups an intra-gastric dose Glutamine, or VSL#3+Glutamine 30 minutes prior...

Abstract Background Chromobox Homolog 1 (CBX1) plays a crucial role in the pathogenesis of numerous diseases, including evolution and advancement diverse cancers. The CBX1 pan-cancer its mechanism hepatocellular carcinoma (HCC), however, remains to be further investigated. Methods Bioinformatics approaches were harnessed scrutinize CBX1’s expression profile, association with tumor staging, potential impact on patient outcomes across various Single-cell RNA sequencing data facilitated...

Rationale: For the high prevalence of frail in patients with chronic obstructive pulmonary disease (COPD), further study should explore an in-depth understanding relationship between frailty and prognosis COPD. Objective: To determine correlation risk acute exacerbation, hospitalizations, mortality older stable Participants Methods: Consecutive adults (≥ 65) diagnosed COPD from January 2018 to July 2019, average follow-up 546 days (N = 309). Frailty was defined by Fried phenotype. Poisson...

Measurement of estimated glucose disposal rate (eGDR) has been demonstrated to be an indicator insulin resistance (IR) and a risk sign for long-term outcomes in those with ischemic heart disease type 2 diabetes mellitus (T2DM) having coronary artery bypass grafting (CABG). After elective percutaneous intervention (PCI), the usefulness eGDR prognosis non-ST-segment elevation acute syndrome (NSTE-ACS) non-diabetes is yet unknown.1510 NSTE-ACS patients who underwent PCI 2015 (Beijing Anzhen...

High-risk human papilloma virus (hrHPV) is the main causal factor of cervical precancer and cancer when persistent infection left untreated. Previous studies have confirmed vaginal microbiota associated with HPV development lesions. The at different parts female genital tract closely related but from each other. To analyze distinction between hrHPV(+) women in China, one hundred subjects were recruited, including 10 patients HPV16/18(+) carcinoma, 38 no 32 other 20 healthy controls HPV(-)....

Purpose: To explore the impact of frailty on adverse outcomes in elderly hemodialysis (HD) patients. Patients and Methods: An observational prospective cohort study was conducted patients (≥ 60) with HD, an average 12-month follow-up. Fried phenotype (FFP) used to define frailty. Negative binomial regression estimate incidence emergency visits, hospitalizations, acute cardiovascular events, falls within a year. Cox analysis assess influence all-cause mortality HD Results: Our enrolled 150...

Objective: This study explored whether anticoagulation is safe for frail and non-frail elderly patients who have nonvalvular atrial fibrillation (NVAF). Methods: At hospital discharge, the anticoagulant regimen frailty status were recorded 361 (aged ≥ 75 y) with NVAF. The followed 12 months. endpoints included occurrence of thrombosis; bleeding; all-cause death; cardiovascular events. Results: affected 50.42% population rate was 44.04%. age (OR 0.948, P = 0.006), paroxysmal NVAF 0.384, <...

The Tibetan medicinal botanical drug Taoerqi has long been recognized for its anti-inflammatory, antibacterial, and tumor-inhibitory properties. Botanical focuses on the isolation characterization of secondary metabolites from Pseudomonas frederiksbergensis, an endophytic bacterium isolated roots. were obtained through fermentation purification processes evaluated their anti-breast cancer activities using cellular assays transcriptomic analysis. Key regulatory targets, including SARM1, RGS5,...

Human papillomavirus (HPV) infection, especially persistent high-risk HPV, is associated with cervical cancer. Female reproductive tract microecological disorders and lower genital infections have been increasingly correlated HPV infection lesions. Due to their common risk factors transmission routes, coinfection other sexually transmitted (STIs) has become a concern. Additionally, the clinical significance of Mycoplasma subtypes appear vary. This study aimed assess correlations between STIs...

The prognostic value of triglyceride-glucose (TyG) has been well described in patients with coronary artery disease (CAD). Hyperhomocysteinemia (HHcy) promotes insulin resistance and also regarded as a potential risk factor for cardiovascular disease. However, the TyG acute syndrome (ACS) undergoing percutaneous intervention (PCI) interaction between HHcy remain unclear. A total 1,734 ACS PCI were continuously enrolled June 2016 November 2017 at Beijing Anzhen Hospital. Patients categorized...

Left atrium (LA) is an integral component of left heart remodeling, reflecting hemodynamics and ventricular status. It remains uncertain whether atrial diameter (LAD) can be utilized for predicting evaluating the occurrence failure (HF) in middle-aged elderly individuals. The study aimed to explore correlation between LAD HF individuals, elucidating timing relation LAD. retrospective-prospective investigated 4025 patients who underwent echocardiography at Zhongshan Hospital's Cardiovascular...

Mixed vaginitis is the result of simultaneous presence different pathogenic processes mediated by at least two types vaginal pathogens. Among various mixed presentations, bacterial vaginosis (BV) plus vulvovaginal candidiasis (VVC) presents to be most prevalent form. affects health women all ages worldwide. However, few studies have focused on clinical manifestations, pathogenesis, diagnostic criteria, or therapy vaginitis. We recruited 48 symptomatic patients with diagnoses VVC complicated...

This study aims to determine the effect of radial extracorporeal shock wave therapy (rESWT) versus drug when treating chronic pelvic pain syndrome (CPPS; type III B prostatitis). The included 45 participants with CPPS, divided into two groups: Group I comprised 25 participants, who were treated rESWT (3,000 pulses each; pressure: 1.8–2.0 bar; frequency: 10 Hz) once a week; II consisted 20 received combination an α-blocker and anti-inflammatory agent. Participants for 8 weeks. assessments...

Background: The CHA 2 DS -VASc score is often used for stroke risk stratification in atrial fibrillation (AF) patients. However, its usefulness patients ≥75 years of age with or without AF unclear. Objective: We aimed to investigate whether the can predict ischemic (IS), transient attack, thromboembolism (TE), and mortality elderly AF. Materials methods: During 2013–2014, 1,071 (36.3% concomitant AF) at least 75 old were enrolled, follow-up ended on July 15, 2017. Variables included...

Several members of secreted frizzled-related protein (SFRP) are involved in the process myocardial ischemia-reperfusion injury. However, little is known about role SFRP5 patients with acute ST-segment elevation infarction (STEMI).In this cross-sectional study, 85 first-time anterior STEMI who underwent timely primary percutaneous coronary intervention (PCI) and 35 without artery disease (CAD) were enrolled. Serum levels measured using an enzyme-linked immunosorbent assay kit. Patients...

Bacterial vaginosis (BV) is a common infectious disease of the reproductive tract. Metronidazole treatment, as first line frequently fails at recovery microbiome.

It has been demonstrated that glycated albumin (GA) is significantly associated with diabetes complications and mortality. However, among patients diagnosed non-ST-elevation acute coronary syndrome (NSTE-ACS) administered percutaneous intervention (PCI), the predictive value of GA for poor prognosis unclear.