A5103115753- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Vascular Procedures and Complications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Valve Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrovascular and Carotid Artery Diseases
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
- Cardiovascular Health and Disease Prevention
- Heart rate and cardiovascular health
- Peripheral Artery Disease Management
- Advanced Glycation End Products research
- Protease and Inhibitor Mechanisms
- Cervical Cancer and HPV Research
- Signaling Pathways in Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Monoclonal and Polyclonal Antibodies Research
Beijing Anzhen Hospital
2015-2025
Capital Medical University
2015-2025
Bioscience (China)
2024
Beijing Institute of Water
2019-2022
Beijing Chao-Yang Hospital
2015
Harbin Medical University
2002
The triglyceride-glucose (TyG) index is an alternative marker of insulin resistance (IR) and closely associated with the prevalence prognosis atherosclerotic cardiovascular disease (ASCVD). However, association between TyG in-stent restenosis (ISR) after drug-eluting stent (DES) implantation in patients acute coronary syndrome (ACS) remains unknown.The present study retrospectively recruited who were admitted for ACS underwent angiography at 6 to 24 months successful DES-based percutaneous...
The triglyceride-glucose (TyG) index, which is a reliable substitute indicator for insulin resistance, has been considered an independent risk factor long-term outcomes in patients with cardiovascular disease. However, it remains unknown whether the TyG index associated poor prognosis acute coronary syndrome (ACS) prior artery bypass grafting (CABG) undergoing percutaneous intervention (PCI).A total of 1158 ACS CABG PCI were retrospectively studied. was calculated by ln[fasting triglyceride...
To evaluate the associations between serum anion gap (AG) with severity and prognosis of coronary artery disease (CAD).
Recently, the atherogenic index of plasma (AIP) has been proposed as a novel, reliable atherogenicity marker. This study aimed to investigate association AIP with risk in-stent restenosis (ISR) in patients acute coronary syndrome (ACS).
Transradial approach, which is now widely used in coronary angiography and intervention, may be advantageous with respect to the femoral access due lower incidence of vascular complications. Transulnar approach has been proposed for elective procedures patients not suitable transradial approach. The objective this study was evaluate safety efficacy transulnar versus intervention.Two hundred forty undergoing angiography, followed or by were randomized (TUA) (TRA). Doppler ultrasound...
Abstract Background Recent studies have substantiated the role of triglyceride glucose (TyG) index in predicting prognosis coronary artery disease (CAD) patients, while no relevant revealed association between TyG and collateralization event chronic total occlusion (CTO). The current study intends to explore whether, or what extent, is associated with impaired CAD patients CTO lesions. Methods enrolled 1093 undergoing cardiac catheterization for at least one lesion. Data were collected from...
Abstract Background: T cell engagers (TCEs) have been clinically validated but are mostly limited to hematological cancers. Developing BiTEs for solid tumors faces hurdles such as penetration into tissue, suppressive nature of the tumor microenvironment and systemic toxicity, etc. This study aims tackle these challenges by delivering an mRNA-encoded TCE targeting hepatocellular carcinoma antigen Glypican-3 (GPC3) directly liver thus enhancing local concentration promote anti-tumor activity...
Abstract Background: Persistent infection with human papillomavirus (HPV) 16 and 18, two most prevalent high-risk subtypes, is a predominant cause to cancers such as head neck, cervical cancers. Although prophylactic vaccines can provide protection from infection, therapeutic efficacious drugs for already developed HPV-related are badly needed. The conventional based on protein or peptides have not reached satisfactory efficacy patients due lack of strong immunogenicity fully unleash the...
ABSTRACT Adherence to antihypertensive medications is essential for blood pressure (BP) control, influencing long‐term outcomes in hypertensive patients. This study examines the association between visit‐to‐visit variability BP and heart rate (HR) its effect on adherence beta‐blocker therapy among outpatients. Conducted across 160 hospitals China from January 1, 2011, December 31, this included 9225 outpatients prescribed metoprolol succinate. HR were assessed over three visits (baseline,...
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature atherosclerosis. This study aimed to evaluate the effect PVAT-derived exosomes (EXOs) on lipid accumulation macrophages and verify anti-atherogenic characteristics PVAT. Methods Results: We extracted EXOs from PVAT subcutaneous (SCAT) wild-type C57BL/6J mice. After coincubation, were...
To explore the aetiology of obstructive azoospermia (OA) in Chinese infertility patients, 133 OA patients was included this study diagnosed and evaluated by one major specialist trained urological infertility. We retrospected medical records to collect relative information. All had been underwent physical examination, ultrasound scan urogenital system, serum hormone tests, genetic tests two separate semen analyses. The mean age all 32.7 ± 6.8 years. A total 266 reproductive tract units...
Several members of secreted frizzled-related protein (SFRP) are involved in the process myocardial ischemia-reperfusion injury. However, little is known about role SFRP5 patients with acute ST-segment elevation infarction (STEMI).In this cross-sectional study, 85 first-time anterior STEMI who underwent timely primary percutaneous coronary intervention (PCI) and 35 without artery disease (CAD) were enrolled. Serum levels measured using an enzyme-linked immunosorbent assay kit. Patients...
Purpose We aimed to describe the facilitators and barriers of physical activity for patients with coronary heart disease.
Contrast-induced acute kidney injury (CI-AKI) is associated with increasing in-hospital and long-term adverse clinical outcomes in high-risk patients undergoing percutaneous coronary intervention (PCI). Contrast media (CM)-induced renal tubular cell apoptosis reported to participate this process by activating endoplasmic reticulum (ER) stress. An angiotensin II type 1 receptor (AT1R) antagonist can alleviate ER stress-induced streptozotocin (STZ)-induced diabetic mice reduce CM-induced...
To investigate whether tauroursodeoxycholic acid (TUDCA) could attenuate contrast media (CM)-induced renal tubular cell apoptosis by inhibiting endoplasmic reticulum stress (ERS), we exposed HK-2 cells to increasing doses of meglumine diatrizoate (20, 40, and 80 mg I/mL) for 2 16 hours, with/without TUDCA preconditioning 24 hours. Cell viability test, Hoechst 33258 staining, flow cytometry were used detect diatrizoate-induced apoptosis, while real-time polymerase chain reaction Western blot...
Omentin-1, as a novel adipocytokine, ameliorates obesity-associated disorders and suppresses the development of atherosclerotic lesions. The present research investigated correlation between serum omentin-1 post-infarction myocardial function.A total 52 patients with first anterior ST-segment elevation infarction (STEMI) were recruited into this study. Participants divided two subgroups according to median admission concentration. δ1 was defined (admission level) - (serum at 24 hours after...
To explore treatment with Direct Oral Anticoagulants (DOACs) in left ventricular thrombus (LVT) after ST-segment elevation myocardial infarction (STEMI) patients who underwent percutaneous coronary intervention (PCI).Contemporary data regarding using DOACs for LVT STEMI PCI is limited.To investigate the efficacy and safety of on post PCI.This retrospective study enrolled within 1month from onset received warfarin or at discharge. The primary endpoint was resolution. Secondary endpoints were...
The transradial approach (TRA) is commonly applied for coronary catheterization. However, there are few reports on the safety and feasibility of catheterization in patients with prior artery bypass graft (CABG) surgery. We retrospectively evaluated 124 consecutive who underwent angiography intervention via (TRA group, n = 68) or transfemoral (TFA 56). baseline clinical characteristics between 2 groups were similar except myocardial infarction. No significant difference ( P > .05)was...
Background and Aims: Epicardial adipose tissue, exosomes, miRNAs have important activities in atherosclerosis. The purpose of this study was to establish miRNA expression profiles epicardial tissue-derived exosomes patients with coronary Methods: Biopsies tissue were obtained from without artery disease (CAD, n = 12 NCAD, 12) during elective open-heart surgeries. Tissue incubated DMEM-F12 for 24 hours. Exosomes isolated, then nanoparticle tracking analysis, transmission electron microscopy,...