Chi Liu

ORCID: 0000-0003-2872-9576
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About
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Research Areas
  • Neonatal Respiratory Health Research
  • Cancer-related molecular mechanisms research
  • Asthma and respiratory diseases
  • Epigenetics and DNA Methylation
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • RNA modifications and cancer
  • Immune Response and Inflammation
  • Immune Cell Function and Interaction
  • Cell Adhesion Molecules Research
  • Respiratory viral infections research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Neuropeptides and Animal Physiology
  • Renal Diseases and Glomerulopathies
  • RNA Research and Splicing
  • Natural product bioactivities and synthesis
  • Pediatric health and respiratory diseases
  • Cancer-related gene regulation
  • Coronary Interventions and Diagnostics
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Wnt/β-catenin signaling in development and cancer
  • Acute Myeloid Leukemia Research
  • Antimicrobial Peptides and Activities
  • Acute Myocardial Infarction Research
  • Antiplatelet Therapy and Cardiovascular Diseases

University of Electronic Science and Technology of China
2021-2025

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022-2025

Fudan University
2020-2025

Jingzhou Central Hospital
2019-2025

National Clinical Research
2021-2025

Central South University
2014-2024

Xiangya Hospital Central South University
2020-2024

Northeast Agricultural University
2024

Zhejiang Energy Research Institute
2024

Zhejiang University
2024

Alzheimer' disease (AD), a progressive neurodegenerative characterized by impairments of cognitive function, is associated with inflammation which suggested to be potential cause synaptic deficits and neuronal loss. Apelin-13, predominant neuropeptide inhibiting effect on inflammation, has beneficial effects cognition memory damage. However, whether apelin-13 can protect neurons ameliorate AD inflammatory response the underling mechanism remains largely unknown. To test this hypothesis, rats...

10.3389/fphar.2019.00395 article EN cc-by Frontiers in Pharmacology 2019-04-16

Abstract Abnormal activation of the nuclear factor‐kappa B (NF‐κB) signaling pathway is closely implicated in triple‐negative breast cancer growth, metastasis, and tumor immune escape. In this study, anti‐cancer effects icariin, a natural flavonol glycoside, toward cells underlying mechanisms were investigated. This investigation showed that icariin selectively inhibited proliferation triggered apoptosis concentration‐ time‐dependent manner, but exhibited little cytotoxicity normal cells....

10.1111/cas.14648 article EN cc-by-nc Cancer Science 2020-09-21

Insulin resistance (IR), evaluation of which is difficult and complex, closely associated with cardiovascular disease. Recently, various IR surrogates have been proposed proved to be highly correlated assessed by the gold standard. It remains indistinct whether different perform equivalently on prognostic prediction stratification following percutaneous coronary intervention (PCI) in non-ST-segment elevation acute syndrome (NSTE-ACS) patients without type 2 diabetes mellitus (T2DM).

10.1186/s12933-021-01383-7 article EN cc-by Cardiovascular Diabetology 2021-09-18
Dong‐Yan Zhang De‐Wei An Yu‐Ling Yu Jesús D. Melgarejo José Boggia and 95 more Dries S. Martens Tine W. Hansen Kei Asayama Takayoshi Ohkubo Katarzyna Stolarz‐Skrzypek Sofia Malyutina Edoardo Casiglia Lars Lind Gladys Elena Maestre Ji‐Guang Wang Yutaka Imai Kalina Kawecka−Jaszcz Edgardo Sandoya Marek Rajzer Tim S. Nawrot Eoin O’Brien Wen‐Yi Yang Jan Filipovský Auxiliadora Graciani José R. Banegas Yan Li Jan A. Staessen Blerim Mujaj Jan A. Staessen FF Wei Yu Yl DY Zhang De‐Wei An Yi‐Bing Cheng QH Guo Yejin Kang Yaxian Li Huang Jf Q. F. Huang CS Sheng JG Wang Ying Wang DY Zhang Wei Zhang WY Yang Chi Liu FF Wei Jan Filipovský Jitka Seidlerová Marie Tichá Tine W. Hansen Hans Ibsen Jørgen Jeppesen C. Torp-Pedersen E. Dolan Eoin O’Brien Edoardo Casiglia Valérie Tikhonoff Kei Asayama Masahiro Kikuya Masahiro Satoh Yukako Tatsumi Takahisa Murakami Megumi Tsubota‐Utsugi Takuo Hirose Kyoko Nomura Hirohito Metoki Atsushi Hozawa Yutaka Imai Takayoshi Ohkubo Natasza Gilis‐Malinowska Agnieszka Łebek-Szatańska Krzysztof Narkiewicz Marcin Cwynar Jerzy Gąsowski Tomasz Grodzicki Kalina Kawecka−Jaszcz Wojciech Lubaszewski Agnieszka Olszanecka Katarzyna Stolarz‐Skrzypek Barbara Wizner Wiktoria Wojciechowska Jolanta Życzkowska JR Banegas Verónica Cabanas Francisco J. Caballero Auxiliadora Graciani Esther López‐García P Guallar Fernando Rodrı́guez-Artalejo Sofia Malyutina Elena Pello Gabriela Šimonová М. И. Воевода Kristina Björklund‐Bodegârd Lars Lind Björn Zethelius Manuel Alva Bianchi José Boggia Edgardo Sandoya

Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed association of with percentage time that ambulatory blood pressure (ABP) within target range (PTTR) proposed by 2024 European Society Cardiology (ESC) guidelines for (BP) management. In a person-level meta-analysis 14 230 individuals enrolled in population cohorts, systolic and diastolic ABPs were combined to assess 24-h, daytime, nighttime PTTR thresholds non-elevated ABP set at <115/65,...

10.1093/eurheartj/ehaf220 article EN cc-by-nc European Heart Journal 2025-03-19

To cite this article: Huerta-Yepez S, Baay-Guzman GJ, Bebenek IG, Hernandez-Pando R, Vega MI, Chi L, Riedl M, Diaz-Sanchez D, Kleerup E, Tashkin DP, Gonzalez FJ, Bonavida B, Zeidler Hankinson O. Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma rhinitis. Allergy 2011; 66: 909–918. Background: New therapies are necessary to address inadequate control many patients. This study sets out investigate whether hypoxia-inducible factor (HIF) essential...

10.1111/j.1398-9995.2011.02594.x article EN Allergy 2011-04-26

The present study aimed to investigate the effect and mechanism of angiotensin II-induced ferroptosis in vascular endothelial cells.In vitro, HUVECs were treated with AngII, AT1/2 R antagonist, P53 inhibitor, or their combinations. MDA intracellular iron content evaluated using an ELISA assay. expression ALOX12, P53, P21, SLC7A11 determined by western blotting then confirmed through RT-PCR.As concentration Ang II (0, 0.1,1,10,100, 1000uM for 48 h) increased, level increased HUVECs. Compared...

10.1080/10641963.2023.2180019 article EN cc-by-nc Clinical and Experimental Hypertension 2023-03-01

Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of 18F-DHMT, a marker ROS, for early detection cardiotoxicity rats. Echocardiography was performed at baseline and 4, 6, 8 weeks post-doxorubicin initiation, whereas vivo superoxide production measured 4 6 with 18F-DHMT positron emission tomography. Left ventricular ejection fraction (LVEF) not significantly decreased until treatment, myocardial elevated weeks. imaging...

10.1016/j.jacbts.2018.02.003 article EN cc-by-nc-nd JACC Basic to Translational Science 2018-05-30

In plants, R2R3 MYB transcription factors (TFs) consist of one large gene family and are involved in the regulation many developmental processes various stresses. However, functions most TFs woody plants remain unknown. Here, PtrMYB94, an TF from Populus trichocarpa, is characterized to be drought responses abscisic acid (ABA) signaling. PtrMYB94 encodes a nuclear-localized TF. RT-PCR results showed that transcripts were relatively abundant leaves stems, induced rapidly response dehydration...

10.1093/treephys/tpz113 article EN Tree Physiology 2019-10-17

Background/Aims: Hepatocellular carcinoma (HCC) has a high morbidity as well mortality and is believed to be one of the most prevalent cancers worldwide. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) involved in numerous cancers, including HCC. This study aimed explore role MALAT1 HCC progression. Methods: expression levels Vimentin tissues relative pair-matched adjacent normal liver were analyzed by RT-PCR, immunohistochemistry. Using bioinformatics...

10.1159/000493962 article EN cc-by-nc-nd Cellular Physiology and Biochemistry 2018-01-01

An introgression line RBPH660, derived from wild rice Oryza rufipogon, showed stable resistance to brown planthopper (BPH). Segregation analysis indicated BPH of RBPH660 was controlled by multiple genes/QTLs. By using the bulked segregant (BSA)-seq method, two genomic regions harboring QTLs were identified 1.20 16.70 Mb on chromosome 4 and 10.20 12.60 9 in respectively. A major locus, designated as Bph35 accounting for 51.27% phenotypic variation with a LOD score 42.51, mapped candidate...

10.1016/j.rsci.2020.04.006 article EN cc-by-nc-nd Rice Science 2020-04-30

Biodynamic models representing distributed human-seat interactions can assist seat design. This study sought to develop a finite element (FE) model the soft tissues of body supported by seating and vertical in-line apparent mass fore-and-aft cross-axis seated human during vibration excitation. The was developed with rigid parts torso segments, skeletal structures (pelvis femurs) deformable buttocks thighs. had three modes at frequencies less than 15 Hz provided reasonable mass. be represent...

10.1080/00140139.2015.1005164 article EN Ergonomics 2015-02-26

Luminal preservation of the intestine is an attractive method to locally mitigate injury and ischemic-reperfusion in small bowel transplantation (SBT) because this has a potential maintain intestinal graft integrity. Hydrogen noted as antioxidant material by reducing hydroxyl radicals. We hypothesized that hydrogen-containing solution can be optimum for luminal SBT.Ischemic reperfusion was induced Lewis rats occlusion supramesenteric artery vein 90 min. Experimental protocols were divided...

10.1097/tp.0000000000000510 article EN Transplantation 2015-01-16

Cardiac fibrosis secondary to long‑term hypertension is known promote cardiac dysfunction; however, few therapeutic agents are available for the treatment of this condition in clinical practice. The heptapeptide alamandine (Ala) has recently been identified as a component renin‑angiotensin system (RAS), which exerts protective effect against hypertrophy; it unknown whether Ala may also be useful fibrosis. In present study, potential effects on hypertension‑induced were investigated an aged,...

10.3892/mmr.2019.10167 article EN cc-by-nc-nd Molecular Medicine Reports 2019-04-15

Aging is characterized by a progressive loss of physiological integrity, leading to impaired organ function and, ultimately, increased vulnerability death. Many complex diseases are related aging, including asthma. In the lung, airway epithelium serves as first barrier prevent access inspired external stimuli and dictates initial stress responses. Notably, in mucosa asthma patients, an increase senescent epithelial cells has been detected. Although it speculated that senescence could...

10.1111/febs.14749 article EN FEBS Journal 2019-01-12
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