A5100705188- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuropeptides and Animal Physiology
- Renal Diseases and Glomerulopathies
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Pediatric health and respiratory diseases
- Cancer-related gene regulation
- Coronary Interventions and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Acute Myeloid Leukemia Research
- Antimicrobial Peptides and Activities
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
University of Electronic Science and Technology of China
2021-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022-2025
Fudan University
2020-2025
Jingzhou Central Hospital
2019-2025
National Clinical Research
2021-2025
Central South University
2014-2024
Xiangya Hospital Central South University
2020-2024
Northeast Agricultural University
2024
Zhejiang Energy Research Institute
2024
Zhejiang University
2024
Alzheimer' disease (AD), a progressive neurodegenerative characterized by impairments of cognitive function, is associated with inflammation which suggested to be potential cause synaptic deficits and neuronal loss. Apelin-13, predominant neuropeptide inhibiting effect on inflammation, has beneficial effects cognition memory damage. However, whether apelin-13 can protect neurons ameliorate AD inflammatory response the underling mechanism remains largely unknown. To test this hypothesis, rats...
Abstract Abnormal activation of the nuclear factor‐kappa B (NF‐κB) signaling pathway is closely implicated in triple‐negative breast cancer growth, metastasis, and tumor immune escape. In this study, anti‐cancer effects icariin, a natural flavonol glycoside, toward cells underlying mechanisms were investigated. This investigation showed that icariin selectively inhibited proliferation triggered apoptosis concentration‐ time‐dependent manner, but exhibited little cytotoxicity normal cells....
Insulin resistance (IR), evaluation of which is difficult and complex, closely associated with cardiovascular disease. Recently, various IR surrogates have been proposed proved to be highly correlated assessed by the gold standard. It remains indistinct whether different perform equivalently on prognostic prediction stratification following percutaneous coronary intervention (PCI) in non-ST-segment elevation acute syndrome (NSTE-ACS) patients without type 2 diabetes mellitus (T2DM).
Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed association of with percentage time that ambulatory blood pressure (ABP) within target range (PTTR) proposed by 2024 European Society Cardiology (ESC) guidelines for (BP) management. In a person-level meta-analysis 14 230 individuals enrolled in population cohorts, systolic and diastolic ABPs were combined to assess 24-h, daytime, nighttime PTTR thresholds non-elevated ABP set at <115/65,...
To cite this article: Huerta-Yepez S, Baay-Guzman GJ, Bebenek IG, Hernandez-Pando R, Vega MI, Chi L, Riedl M, Diaz-Sanchez D, Kleerup E, Tashkin DP, Gonzalez FJ, Bonavida B, Zeidler Hankinson O. Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma rhinitis. Allergy 2011; 66: 909–918. Background: New therapies are necessary to address inadequate control many patients. This study sets out investigate whether hypoxia-inducible factor (HIF) essential...
The present study aimed to investigate the effect and mechanism of angiotensin II-induced ferroptosis in vascular endothelial cells.In vitro, HUVECs were treated with AngII, AT1/2 R antagonist, P53 inhibitor, or their combinations. MDA intracellular iron content evaluated using an ELISA assay. expression ALOX12, P53, P21, SLC7A11 determined by western blotting then confirmed through RT-PCR.As concentration Ang II (0, 0.1,1,10,100, 1000uM for 48 h) increased, level increased HUVECs. Compared...
Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of 18F-DHMT, a marker ROS, for early detection cardiotoxicity rats. Echocardiography was performed at baseline and 4, 6, 8 weeks post-doxorubicin initiation, whereas vivo superoxide production measured 4 6 with 18F-DHMT positron emission tomography. Left ventricular ejection fraction (LVEF) not significantly decreased until treatment, myocardial elevated weeks. imaging...
In plants, R2R3 MYB transcription factors (TFs) consist of one large gene family and are involved in the regulation many developmental processes various stresses. However, functions most TFs woody plants remain unknown. Here, PtrMYB94, an TF from Populus trichocarpa, is characterized to be drought responses abscisic acid (ABA) signaling. PtrMYB94 encodes a nuclear-localized TF. RT-PCR results showed that transcripts were relatively abundant leaves stems, induced rapidly response dehydration...
Background/Aims: Hepatocellular carcinoma (HCC) has a high morbidity as well mortality and is believed to be one of the most prevalent cancers worldwide. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) involved in numerous cancers, including HCC. This study aimed explore role MALAT1 HCC progression. Methods: expression levels Vimentin tissues relative pair-matched adjacent normal liver were analyzed by RT-PCR, immunohistochemistry. Using bioinformatics...
An introgression line RBPH660, derived from wild rice Oryza rufipogon, showed stable resistance to brown planthopper (BPH). Segregation analysis indicated BPH of RBPH660 was controlled by multiple genes/QTLs. By using the bulked segregant (BSA)-seq method, two genomic regions harboring QTLs were identified 1.20 16.70 Mb on chromosome 4 and 10.20 12.60 9 in respectively. A major locus, designated as Bph35 accounting for 51.27% phenotypic variation with a LOD score 42.51, mapped candidate...
Biodynamic models representing distributed human-seat interactions can assist seat design. This study sought to develop a finite element (FE) model the soft tissues of body supported by seating and vertical in-line apparent mass fore-and-aft cross-axis seated human during vibration excitation. The was developed with rigid parts torso segments, skeletal structures (pelvis femurs) deformable buttocks thighs. had three modes at frequencies less than 15 Hz provided reasonable mass. be represent...
Luminal preservation of the intestine is an attractive method to locally mitigate injury and ischemic-reperfusion in small bowel transplantation (SBT) because this has a potential maintain intestinal graft integrity. Hydrogen noted as antioxidant material by reducing hydroxyl radicals. We hypothesized that hydrogen-containing solution can be optimum for luminal SBT.Ischemic reperfusion was induced Lewis rats occlusion supramesenteric artery vein 90 min. Experimental protocols were divided...
Cardiac fibrosis secondary to long‑term hypertension is known promote cardiac dysfunction; however, few therapeutic agents are available for the treatment of this condition in clinical practice. The heptapeptide alamandine (Ala) has recently been identified as a component renin‑angiotensin system (RAS), which exerts protective effect against hypertrophy; it unknown whether Ala may also be useful fibrosis. In present study, potential effects on hypertension‑induced were investigated an aged,...
Aging is characterized by a progressive loss of physiological integrity, leading to impaired organ function and, ultimately, increased vulnerability death. Many complex diseases are related aging, including asthma. In the lung, airway epithelium serves as first barrier prevent access inspired external stimuli and dictates initial stress responses. Notably, in mucosa asthma patients, an increase senescent epithelial cells has been detected. Although it speculated that senescence could...