A5079424962- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Chemokine receptors and signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Heat shock proteins research
- Lipid metabolism and biosynthesis
- Advanced Glycation End Products research
- Artificial Intelligence in Healthcare
- TGF-β signaling in diseases
- Peroxisome Proliferator-Activated Receptors
Mudanjiang Medical University
2014-2025
Jilin Medical University
2024
Jilin University
2024
Harbin Medical University
2012-2020
Yunnan Agricultural University
2020
Nanjing University
2007
Prostate cancer is the most commonly diagnosed type of and second leading cause cancer‑associated mortality in males. The efficacy prostate chemotherapy frequently impaired by drug resistance; however, underlying mechanisms this resistance remain elusive. Sex determining region Y-box 2 (Sox2) vital importance regulation stem cell proliferation carcinogenesis. In present study, using MTT, clone formation, cycle apoptosis assays, over-expression Sox2 was demonstrated to enhance paclitaxel...
Background/Aims: Hepatocellular carcinoma (HCC) has a high morbidity as well mortality and is believed to be one of the most prevalent cancers worldwide. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) involved in numerous cancers, including HCC. This study aimed explore role MALAT1 HCC progression. Methods: expression levels Vimentin tissues relative pair-matched adjacent normal liver were analyzed by RT-PCR, immunohistochemistry. Using bioinformatics...
Long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression by acting as competing endogenous (ceRNAs). However, lncRNA-associated ceRNAs oncogenesis are not fully understood. The present study aims to determine whether a ceRNA network can serve prognostic marker human prostate cancer (PCa). In order identify and key lncRNAs PCa, we constructed differentially expressed (DELs)-differentially miRNAs (DEMis)-differentially mRNAs (DEMs) regulatory based on theory...
Background Coffee is one of the most consumed beverages worldwide, but effects on thyroid are unknown. This study aims to examine association between coffee and function. Methods Participant data (≥ 20 years, n = 6578) for observational were obtained from NHANES 2007-2012. Analysis was performed using weighted linear regression models multiple logistic models. Genetic datasets Hyperthyroidism Hypothyroidism IEU database contained 462,933 European samples. Mendelian randomization (MR) used...
Abstract Background As an oncogene, long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) can promote tumor metastasis. Hyperexpression of MALAT1 has been observed in many malignant tumors, including hepatocellular carcinoma (HCC). However, the role and mechanism HCC remain unclear. Methods Thirty human paracancerous tissue specimens were collected, hepatoma cell lines Huh7 HepG2 cultured according to standard methods. Snail family zinc finger (Slug) expression...
Background: Long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of multiple tumors. However, roles lncRNAs during colon adenocarcinoma and cancer progression remain unclear. This study aimed identify new that act as molecular markers for prevention diagnosis adenocarcinoma. Methods: RNA sequencing (RNA-Seq) data associated with were retrieved from Cancer Genome Atlas (TCGA). Biological processes Gene Ontology (Go) Kyoto Encyclopedia Genomes (KEGG) searched pathways at...
Triglyceride glucose (TyG) index and atherogenic of plasma (AIP) are indicators insulin resistance. However, inadequate evidence indicates that the TyG index, AIP, chronic pain linked. Data from National Health Nutrition Examination Survey (NHANES) between 1999 2004 were used. Directed acyclic graphs used to identify 11 potential confounders. The AIP treated as continuous variables in multivariate logistic regression models assess their association with pain. Furthermore, nonlinear...
Transforming growth factor-α (TGF-α) is upregulated in advanced stages of prostate cancer and strongly correlated with metastasis. However, the effect TGF-α on epithelial-mesenchymal transition (EMT) underlying mechanisms remain unclear. Recently, microRNAs have emerged as new regulators EMT. This study found that treatment DU145 cells suppressed expression epithelial marker E-cadherin increased mesenchymal Vimentin well changed cell morphology from cobblestone shape to spindle shape. The...
Hypoxia is a common phenomenon in prostate cancer, which leads to cell proliferation and tumor growth. Fractalkine (FKN) membrane‑bound chemokine, implicated the progression of human cancer skeletal metastasis. However, association between FKN hypoxia‑induced remains be elucidated. The present study demonstrated that hypoxia induced expression secretion DU145 line. Furthermore, inhibiting activity with anti‑FKN FKN‑specific antibody markedly inhibited proliferation. Under normoxic...
Aim: To investigate the role and mechanisms of AC245100.4 in prostate cancer. Materials & methods: The expression location were examined using real-time PCR situ hybridization. Cell Counting Kit-8, clone formation, flow cytometry vivo assays conducted to determine AC245100.4. RNA antisense purification with mass spectrometry immunoprecipitation performed identify proteins that bind Western blotting was quantify protein. Results:AC245100.4 upregulated cancer mainly located cytoplasm....
Cervical cancer is one of the most common malignant tumors in women, and its morbidity mortality are increasing year by worldwide. Therefore, an urgent challenging task to identify potential biomarkers for cervical cancer. This study aims hub genes based on GEO database then validate their prognostic values multiple databases. By analysis, we obtained 83 co-expressed differential from ( GSE63514 , GSE67522 GSE39001 ). GO KEGG enrichment analysis showed that these it mainly involved DNA...
MiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) bind to miRNAs competitively affect mRNA expression. The ceRNA network is still unclear in breast cancer. In this study, a was constructed, new treatment prognosis targets biomarkers for cancer were explored.
// Dong Li 1, * , Hui Sun 3, Wen-jing 1 Hong-bo Bao 4 Shu-han Si Jia-lin Fan Ping Lin Rong-jun Cui 5 Yu-jia Pan Si-min Wen Xiu-lan Zheng 2, $ Xiao-guang Yu Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China 2 Ultrasonography, University Cancer Hospital, 3 Clinical Laboratory, The Second School Inner Mongolia for Nationalities, (Inner Forestry General Hospital), Hulunbuir, 022150, Neurosurgery, Mudanjiang Mudanjiang, 157000,...
Gastric cancer is the fourth most common type and second leading cause of cancer‑associated mortality worldwide. Metastasis a crucial feature its progression. DNA methylation provides key epigenetic signature in regulation pathway, implicated transcriptional regulation. CpG sites, which are associated with gene activity, underrepresented mammalian genome tend to be clustered within islands (CGIs) located vicinity transcription start sites majority protein‑coding genes humans. The inhibitor,...
This study aimed to construct a high-performance prediction and diagnosis model for type 2 diabetic retinopathy (DR) identify key correlates of DR. utilized cross-sectional dataset 3,000 patients from the People's Liberation Army General Hospital in 2021. Logistic regression was used as baseline compare performance machine learning related factors. The recursive feature elimination cross-validation (RFECV) algorithm select features. Four models, support vector (SVM), decision tree (DT),...
MicroRNAs (miRNAs/miRs), which are endogenous non-coding single-stranded RNAs 19-25 nucleotides in length, regulate gene expression by blocking translation or transcription repression. The present study revealed that miR-3160-5p was widely expressed prostate cancer cells reverse transcription-quantitative polymerase chain reaction. There a negative association between the of and F-box WD repeat domain containing 8 (Fbxw8) DU145 cells. A luciferase activity assay used to verify Fbxw8 is...
miR-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and thought to be a related diagnostic marker. Previous studies have indicated the effects of iodine on oncogenic activation. However, effect proliferation PTC cells associated underlying mechanisms remain unclear. We found that was downregulated smad4 upregulated patients exposed high concentration by situ hybridisation (ISH) immunohistochemical (IHC). NaI (10 −3 M) treatment Smad4 cell lines. Luciferase assay used confirm...
Digestive system pan-cancer is a general term for digestive tumors including colorectal carcinoma (CRC), esophageal (ESCA), stomach adenocarcinoma (STAD), and liver hepatocellular (LIHC). Since the anatomical location, function metabolism are closely related, there may be similarities in development progression of these tumors. Hypoxia consequence an imbalance between oxygen demand supply, intracellular hypoxia associated with malignant progression, treatment resistance, poor prognosis...
Urinary pan-cancer system is a general term for tumors of the urinary including renal cell carcinoma (RCC), prostate cancer (PRAD), and bladder (BLCA). Their location, physiological functions, metabolism are closely related, making occurrence outcome these highly similar. Cuproptosis new type death that different from apoptosis plays an essential role in tumors. Therefore, it necessary to study molecular mechanism cuproptosis-related lncRNAs prognosis, clinical diagnosis, treatment tumors.In...