A5101865443- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Tumors and Oncological Cases
- Animal Virus Infections Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Animal Disease Management and Epidemiology
- Cancer, Lipids, and Metabolism
- Ion Transport and Channel Regulation
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Kidney Stones and Urolithiasis Treatments
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Pediatric Urology and Nephrology Studies
- Immune Cell Function and Interaction
- Genetic Associations and Epidemiology
- Magnesium in Health and Disease
- Mechanisms of cancer metastasis
- Cancer Cells and Metastasis
- Ureteral procedures and complications
- Cell Adhesion Molecules Research
Peking University First Hospital
2024
Peking University
2024
Anhui Provincial Children's Hospital
2024
Sichuan Cancer Hospital
2021-2024
University of Electronic Science and Technology of China
2021-2024
Wuhan University
2017-2023
Renmin Hospital of Wuhan University
2017-2023
Shanghai University of Medicine and Health Sciences
2023
Yunnan Agricultural University
2020-2023
Hebei Medical University
2023
// Yongbin Zheng 1 , Chao Yang Shilun Tong Yu Ding Wenhong Deng Dan Song Kuang Xiao Department of Gastrointestinal Surgery, Renmin Hospital Wuhan University, Wuhan, Hubei, PR China Correspondence to: Zheng, email: zhengyongbinhb@163.com Keywords: colorectal cancer, variation, genetic, TINCR, lncRNA Received: January 05, 2017 Accepted: February 13, Published: March 24, ABSTRACT Colorectal cancer (CRC) accounts for the leading causes cancer-related morbidity and mortality. However, a large...
As a heterogeneous disease, colorectal cancer (CRC) presents great challenge to individualized treatment due its lymph node metastasis (LNM). Existing studies have shown that immune and stromal components in extracellular matrix (ECM) act as important part tumorigenicity progression, while their roles LNM not been fully elucidated. Here, crucial ECM-related genes responsible for CRC were selected by multi-omics analysis.Firstly, we characterized the infiltration landscape of samples from The...
Housekeeping proteins are essential endogenous controls for normalization as they expected to be stably expressed. However, the stability of expression level housekeeping needs assessed considering various experimental conditions. Our study evaluated degree variability 7 commonly used with regard their potential utility normalizers in 56 pairs matched colorectal adenocarcinoma (CRC) tissue samples and 6 hepatocellular carcinoma (HCC) using multiple reaction monitoring (MRM) Western blot...
Abstract Cell-free DNA (cfDNA), which is primarily released following cell death, has been described and developed to serve as an effective biomarker in autoimmune diseases may share the pathogenesis with schizophrenia. In this study, we hypothesized explored whether concentrations size distributions of cfDNA are abnormal A total 65 patients schizophrenia (SZ), 29 mood disorders (MD) 62 matched healthy controls (HC) were included study. Fluorescence correlation spectroscopy was used assay...
Abstract Schizophrenia (SCZ) is a highly heritable psychiatric disorder that affects approximately 1% of population around the world. However, early relevant studies did not reach clear conclusions genetic mechanisms SCZ, suggesting additional susceptibility loci exert significant influence on SCZ are yet to be revealed. So, in order identify novel genes account for risk we performed systematic family-based study using whole exome sequencing (WES) 65 Han Chinese families. The analysis 51...
Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, role GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore effect on immunity pan-cancer. Methods: Based RNA sequencing data 33 cancers obtained from Cancer Genome Atlas, we analyzed clinical significance GBPs and focused correlation between tumor microenvironment (TME). Immunotherapy cohort IMvigor210 was used relationship treatment...
Abstract Oxaliplatin displays a wide spectrum of antitumor activities and is widely used in the treatment metastatic colorectal cancer (CRC). However, tumor responses to this agent are variable, underlying mechanisms poorly understood. In present study, oxaliplatin was found strongly inhibit growth HCT116 cells harboring wild-type p53 but only weakly SW480 cells, HT29 or p53−/− which all lack expression. Administration significantly induced accumulation enhanced expression CYP2S1 with p53....
Disulfidptosis is a newly-identified non-programmed cell death mode with tight associations glucose metabolism. Elevated glycolysis an important metabolic feature of tumor cells, which fulfills the energy requirement for their rapid growth and progression. Our present study determined to develop disulfidptosis related gene (DGRG) risk score signature predict prognosis ICI therapeutic responsiveness CRC patients. First, expression clinical profiles patients were obtained from TCGA GEO...
Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose this study was explore the expression profiles lipid metabolism-related genes (LMRG) in colorectal cancer (CRC).The metabolism statuses 500 CRC patients from Cancer Genome Atlas (TCGA) and 523 Gene Expression Omnibus (GEO GSE39582) database were analyzed. risk signature constructed by univariate Cox regression least absolute shrinkage selection operator (LASSO) regression.A novel four-LMRG...
Accumulating studies have shown that the dysregulation of microRNAs is related to carcinogenesis and development gastric cancer (GC), role miR-635 in GC remains largely unknown. Kinesin Family Member C1 (KIFC1) mRNA expression tissues paracancerous cells were detected by quantitative real-time PCR. KIFC1 protein normal was immunohistochemistry western blot. Cell proliferation monitored Counting Kit-8 assay 5-bromo-2′-deoxyuridine assay. Transwell employed detect migration invasion cells. The...
In patients with gastric cancer (GC), peritoneal metastasis is an indication of the end stage and often indicates a poor outcome. The diagnosis metastasis, especially occult (OPM), remains challenge for surgeons. This study was designed to explore relationship between OPM clinicopathological characteristics preoperative hematological parameters in GC develop nomogram predict probability before surgery.A total 672 from our center were included, including 583 OPM-negative 89 OPM-positive...
Colorectal cancer (CRC) ranks the second most common cause of cancer-related mortality worldwide. Ferroptosis, a recently discovered form programmed cell death different from other, raises promising novel opportunities for therapeutic intervention CRC. This study intended to systematically assess prognosis value and multiple roles ferroptosis-related genes in tumor immune microenvironment CRC.Of 1,192 CRC patients with complete information public datasets (TCGA CRC, GEO GSE39582 GSE17538...
Schizophrenia (SCZ) is a severe psychiatric disorder that affects approximately 0.75% of the global population. Both genetic and environmental factors contribute to development SCZ. SCZ tends run in family while both factor its etiology. Much evidence suggested alterations DNA methylations occurred patients.To investigate potential inheritable pattern methylation family, we performed genome-wide analysis peripheral blood samples from 106 Chinese trios. Genome-wide were quantified by Agilent...
Enhanced Recovery After Surgery (ERAS) has been used to improve surgical outcomes in recent years. However, its safety and efficacy elderly patients with gastric cancer remain unclear. The aim of this study was reveal the ERAS protocol cancer.Elderly (age≥70 years) who underwent gastrectomy were divided into group conventional group. Postoperative complications, postoperative hospital stay, hospitalization expenses, readmission rates compared between two groups.From December 2019 January...
Abstract The 14-3-3 family, which is composed of seven distinct members in humans, plays important roles the cell cycle, apoptosis, synaptic plasticity and neuronal differentiation migration. Previous genetic post-mortem gene expression studies have linked this family to schizophrenia. However, direction changes these has been inconsistent, reports living schizophrenic patients are still lacking. Here, we assessed protein levels peripheral blood leukocytes from drug-naïve first-episode...
Abstract Background In a previous study, persistent pain was suggested to be risk factor for tumor patients. However, the mechanism underlying this phenomenon is still unclear. Substance P (SP), pain-related neuropeptide secreted by neural system and immune system, plays an important role in induction maintenance of pain. Methods order explore whether SP participates influence on progression, serum samples lung cancer breast patients were collected tested. An elevated expression found with...