A5082531996- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Intestinal and Peritoneal Adhesions
- Congenital Diaphragmatic Hernia Studies
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- RNA modifications and cancer
- Blood groups and transfusion
- Medical Research and Treatments
- Bone Tissue Engineering Materials
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Preterm Birth and Chorioamnionitis
- Congenital Anomalies and Fetal Surgery
- Parvovirus B19 Infection Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pelvic floor disorders treatments
Children's Hospital of Zhejiang University
2011-2025
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2022-2025
Chengde Medical University
2024
Institute of Chemistry
2013-2023
Beijing National Laboratory for Molecular Sciences
2013-2023
Southern Medical University Shenzhen Hospital
2010-2023
Chinese Academy of Sciences
2013-2023
State Key Laboratory of Polymer Physics and Chemistry
2013-2023
Tianjin University of Traditional Chinese Medicine
2020-2022
<h3>Importance</h3> Several respiratory support techniques are available to minimize the use of invasive mechanical ventilation (IMV) in preterm neonates. It is unknown whether noninvasive high-frequency oscillatory (NHFOV) more efficacious than nasal continuous positive airway pressure (NCPAP) or intermittent (NIPPV) neonates after their first extubation. <h3>Objective</h3> To test hypothesis that NHFOV NCPAP NIPPV reducing IMV extubation and until neonatal intensive care unit discharge...
The NASONE (Nasal Oscillation Post-Extubation) trial showed that noninvasive high-frequency oscillatory ventilation (NHFOV) slightly reduces the duration of invasive mechanical (IMV) in preterm infants, whereas NHFOV and intermittent positive pressure (NIPPV) result fewer reintubations than nasal continuous airway (NCPAP). It is unknown whether similarly effective extremely neonates or those with more severe respiratory failure (based on previous CO2 levels).To clarify better NIPPV NCPAP...
Abstract Objective To describe the sonographic features and perinatal outcome of congenital vascular rings diagnosed prenatally at a single tertiary care institution. Methods All cases by prenatal ultrasound between July 2005 December 2009 were identified referral center using an established database. The diagnosis was confirmed postnatal echocardiography for live‐born infants or autopsy terminated cases. Results overall incidence ring during this 5‐year period 0.086% (81 among 94 321 women...
Placing a physical barrier between the injured site and adjacent tissues is very common highly effective approach to prevent abdominal adhesions in these days. A biodegradable trilayered was fabricated formation of adhesions, which poly(lactide-co-glycolide)/poly(lactide)-b-poly(ethylene glycol) (PLGA/PLA-b-PEG) electrospun layer sandwiched layers carboxymethyl chitosan (CMCS) sponge. The hydrophilic CMCS sponge with glycerin (GL) could adhere surface wound easily, present great hemostatic...
A multiple targeted drug carrying bilayer membrane for preventing an abdominal adhesion is prepared by electrospinning. Two bioactive drugs were successfully incorporated into this and can be independently released from nanofibrous scaffolds without losing structural integrity functionality of the anti-adhesion membrane. Besides, release profile could easily adjusted optimizing swelling behavior fibrous scaffold. The inner layer bilayered membranes loaded with carbazochrome sodium sulfonate...
Abstract Preeclampsia (PE) is a disorder of pregnancy that characterised by hypertension and significant amount proteinuria beginning after 20 weeks pregnancy. It closely associated with high maternal morbidity, mortality, organ dysfunction or foetal growth restriction. Therefore, it necessary to identify early novel diagnostic biomarkers PE. In the present study, we performed multi-step integrative bioinformatics analysis microarray data for identifying hub genes as With help gene...
A strategy of using silver nanoparticle (AgNP)-loaded electrospun membrane as a novel coating material for preventing implant associated infections is reported. The takes both the advantages excellent antibacterial well no drug resistance properties AgNPs, and widely used biodegradable to serve AgNP carrier physical obstruction bacteria adhesion. However, AgNPs have not been applied in clinical treatment yet because concern potential toxicity. For first time, we systematically investigated...
Increasing evidence suggests that an exaggerated maternal systemic inflammatofrery response may play a central role in the pathogenesis of preeclampsia (PE). Considering growing on microRNAs (miRNAs) and tissue‑specific regulators gene expression, we investigated potential association miR‑210 forkhead box p3 (Foxp3) preeclamptic patients. Serum levels cytokines interleukin (IL)‑6, IL‑10, IL‑17, transforming grown factor‑β1 were detected with ELISA. Reverse‑transcription‑quantitative...
Abstract Background Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and treatment options for advanced CRC are limited. The regulatory mechanisms aberrant NAT10-mediated N4-acetylcytidine (ac4C) modifications in progression remains poorly understood. Consequently, an integrated transcriptomic analysis necessary to fully elucidate role ac4C progression. Methods NAT10 expression levels were analyzed samples compared with those corresponding normal...
Moderate-to-severe bronchopulmonary dysplasia (msBPD) is a prevalent and severe condition in very preterm infants, contributing to long-term respiratory issues. Developing predictive model specific the Chinese population could support early intervention. This research focused on determining risk factors developing for msBPD infants with distress, following 2018 National Institute of Child Health Human Development criteria. A prospective multicenter study was conducted across 26 tertiary...
Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, role GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore effect on immunity pan-cancer. Methods: Based RNA sequencing data 33 cancers obtained from Cancer Genome Atlas, we analyzed clinical significance GBPs and focused correlation between tumor microenvironment (TME). Immunotherapy cohort IMvigor210 was used relationship treatment...
Peritoneal adhesion is the most common adverse effect following abdominal surgery or inflammation. The occurrence in clinical trials has been successfully reduced using barriers. However, shortcomings of frequently used barriers, such as rapid degradation rate gel barrier and inadequate operation ability solid barrier, cannot be ignored. In this study, a fibrous membrane with an ECM-like structure was prepared. properties were significantly by changing surface structure. caused less...
To investigate the relationship between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes mellitus (GDM), to determine whether PAPP-A has improved value for predicting GDM in a Chinese population.Clinical data 599 patients 986 unaffected pregnant women undergoing both antenatal examinations delivery were retrospectively analyzed. First-trimester serum levels compared groups. Binary logistic regression analysis was used explore risk factors GDM, area under receiver...
Background: Globally, the proportion of child deaths that occur in neonatal period remains a high level 37–41%. Differences cause neonate death exist different regions as well economic development countries. The specific aim this study was to investigate causes, characteristics, and differences neonates during hospitalization tertiary Neonatal Intensive Care Unit (NICU) China. Methods: All dead admitted 26 NICUs were included between January l, 2011, December 31, 2011. data collected...
Pulmonary hypertension (PH) is a severe cardiovascular complication of bronchopulmonary dysplasia (BPD) that contributes to the high mortality rates for preterm infants. The objective this study establish prediction model BPD-associated PH (BPD-PH) by integrating multiple predictive factors infants with BPD.A retrospective investigation perinatal clinical records and data echocardiography in all BPD was performed from January 2012 December 2019. A BPD-PH established based on univariate...