Wenbin Dong
A5100548355- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Neonatal Health and Biochemistry
- Mitochondrial Function and Pathology
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Infant Nutrition and Health
- Adipose Tissue and Metabolism
- Infant Development and Preterm Care
- Anesthesia and Neurotoxicity Research
- Neonatal and Maternal Infections
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Retinopathy of Prematurity Studies
- Birth, Development, and Health
- Pediatric health and respiratory diseases
- Infant Health and Development
- Non-Invasive Vital Sign Monitoring
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
Affiliated Hospital of Southwest Medical University
2016-2025
Southwest Medical University
2006-2025
Jinan University
2024
Guangxi Academy of Agricultural Science
2023-2024
Shanghai Clinical Research Center
2020-2024
Network Group (Czechia)
2024
Children's Hospital of Fudan University
2024
Henan Provincial Institute of Cultural Heritage and Archaeology
2024
Dalian Naval Academy
2023
Hebei Medical University
2023
<h3>Importance</h3> Several respiratory support techniques are available to minimize the use of invasive mechanical ventilation (IMV) in preterm neonates. It is unknown whether noninvasive high-frequency oscillatory (NHFOV) more efficacious than nasal continuous positive airway pressure (NCPAP) or intermittent (NIPPV) neonates after their first extubation. <h3>Objective</h3> To test hypothesis that NHFOV NCPAP NIPPV reducing IMV extubation and until neonatal intensive care unit discharge...
Abstract Small for gestational age (SGA) infants have an increased risk of necrotizing enterocolitis (NEC), but SGA has been found to not be a factor the deterioration NEC in previous literature. Few studies focused on correlative factors progression newborns. The present retrospective observational study was performed 64 with Bell’s stage II NEC. dependent variable that progressed III after diagnosis. A stepwise forward multivariate logistic regression model used select potential results...
The NASONE (Nasal Oscillation Post-Extubation) trial showed that noninvasive high-frequency oscillatory ventilation (NHFOV) slightly reduces the duration of invasive mechanical (IMV) in preterm infants, whereas NHFOV and intermittent positive pressure (NIPPV) result fewer reintubations than nasal continuous airway (NCPAP). It is unknown whether similarly effective extremely neonates or those with more severe respiratory failure (based on previous CO2 levels).To clarify better NIPPV NCPAP...
Background: Bronchopulmonary dysplasia (BPD) is one of the most common long-term lung complications prematurely born infants caused by prolonged injury and repair during immature development. Resveratrol has reported to exert anti-inflammatory, antioxidation, antiapoptosis effects. This study aimed investigate effect resveratrol in BPD.Methods: Neonate rats were delivered spontaneously randomized divided into four groups on postnatal day (PN) 0.5: room air (21% O2)+dimethyl sulfoxide (DMSO),...
Fertilizer application practices are one of the major challenges facing agroecology. The agrobenefits combined green manure and chemical fertilizers, potential to replace fertilizers now well documented. However, little is known about impact fertilization on microbial communities tice yield. In this study, diversity bacterial fungal communities, symbiotic networks their relationship with soil function were analyzed in five treatments (N: 100% nitrogen fertilizer alone; M: MN60: couple 60%...
The overutilization of antibiotics in very preterm infants (VPIs) at low risk early-onset sepsis (EOS) is associated with increased mortality and morbidities. Nevertheless, the association early antibiotic exposure bronchopulmonary dysplasia (BPD) remains equivocal.
It has been suggested that mild hypothermia treatment of hypoxia-ischemic encephalopathy (HIE) should start within 6 h after HIE, but many children are admitted to the hospital > h, particularly in developing areas. We aimed determine whether could remain effective 12 birth. According their admission, 152 newborns were enrolled < and 6–12 HIE groups. All received conventional combined with head therapy, according our routine clinical practice. Some only (lacking informed consent)....
Bronchopulmonary dysplasia is a severe and long-term pulmonary disease in premature infants. Hyperoxia-induced acute lung injury plays critical role bronchopulmonary dysplasia. Resveratrol polyphenolic phytoalexin natural agonist of Sirtuin 1. Many studies have shown that resveratrol has protective effect on hyperoxia-induced damage, but its specific mechanism still not clear. Further exploration the possible was main goal this study. In study, human alveolar epithelial cells were used to...
Abstract Recent studies have suggested that dogs were domesticated during the Last Glacial Maximum (LGM) in Siberia, which contrasts with previous proposed domestication centers (e.g. Europe, Middle East, and East Asia). Ancient DNA provides a powerful resource for study of mammalian evolution has been widely used to understand genetic history domestic animals. To maternal Asian dogs, we made complete mitogenome dataset 120 canids from 38 archaeological sites, including 102 newly sequenced...
Supplemental oxygen is commonly used to treat newborns with respiratory disorders. It has been explored that hyperoxia increases oxidative stress, and have the potential adverse effects on developing organs. Mitochondrial biogenesis plays a crucial role in maintaining mitochondrial homeostasis, resveratrol (Res) its unique advantage promoting biogenesis. However, molecular mechanisms controlling hyperoxia-induced kidney injury remain unclear. The aim of this study was evaluate protective...
Exosomes (Exos) derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) hold great potential for treating bronchopulmonary dysplasia (BPD); however, safety concerns and effects of intranasal administration remain unexplored. This study aimed to explore the hUC-MSCs Exos investigate efficacy bio-distribution repeated in neonatal BPD models. Characteristics were analyzed. A subcutaneous tumor formation assay using a single dose or was conducted Crl:NU-Foxn1nu mice. Vital signs,...
Abstract Background The relationship between antenatal corticosteroids (ACS) and preterm infants born to mothers with hypertensive disorders of pregnancy (HDP) remains a subject debate. To evaluate whether the use ACS before delivery was associated neonatal outcomes in very HDP. Methods This multicenter cohort study enrolled all gestational age at 24 31 week admitted tertiary NICUs Chinese Neonatal Network (CHNN) within h birth from 2019 2021. administration defined as least one dose...
Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder marked by progressive, symmetrical muscle weakness and atrophy. While only a limited number of studies on human SMA have demonstrated brain involvement, there are also few reports detailing early MRI changes in patients. In this paper, we present the case child whose initial symptom was limb hypotonia. The child's revealed abnormal signal testing ultimately confirmed diagnosis SMA. By reviewing relevant literature, aim...