A5100418240- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Adipose Tissue and Metabolism
- Burn Injury Management and Outcomes
- Aquaculture disease management and microbiota
- Ocular Surface and Contact Lens
- Inflammasome and immune disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal Imaging and Analysis
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Extracellular vesicles in disease
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Wound Healing and Treatments
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Glaucoma and retinal disorders
- Acute Ischemic Stroke Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA Interference and Gene Delivery
Shihezi University
2025
Ministry of Agriculture and Rural Affairs
2025
Xinjiang Production and Construction Corps
2025
Shenzhen Third People’s Hospital
2025
First Hospital of Jilin University
2015-2025
Jilin University
2015-2025
Soochow University
2011-2025
First Affiliated Hospital of Soochow University
2011-2025
China-Japan Friendship Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
1981-2025
Adolescents with atopic dermatitis (AD) have high disease burden negatively affecting quality of life, limited treatment options. The efficacy and safety dupilumab, a monoclonal antibody, approved for in adolescent patients inadequately controlled AD, remain unknown this patient population.
In the human papillomavirus (HPV) era, best way to assess oropharyngeal squamous carcinomas (SCC) for risk stratification is not clear. Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority tumors are positive ISH negative, significance which unclear.
Bacterial DNA (bDNA) can activate an innate-immune stimulatory "danger" response via toll-like receptor 9 (TLR9). Mitochondrial (mtDNA) is unique among endogenous molecules in that mitochondria evolved from prokaryotic ancestors. Thus, mtDNA retains molecular motifs similar to bDNA. It unknown, however, whether released by shock or capable of eliciting immune responses like We hypothesized shock-injured tissues might release and act as a danger-associated pattern (or "alarmin") neutrophils...
In China, dengue remains an important public health issue with expanded areas and increased incidence recently. Accurate timely forecasts of in China are still lacking. We aimed to use the state-of-the-art machine learning algorithms develop accurate predictive model dengue.Weekly cases, Baidu search queries climate factors (mean temperature, relative humidity rainfall) during 2011-2014 Guangdong were gathered. A index was constructed for developing models combination factors. The observed...
Diabetic wound is one of the common complications in diabetic patients, which exhibits chronic, hard-to-heal characteristics. The healing process wounds impaired by several factors, including excessive oxidative stress, blocked angiogenesis, and bacterial infection. therapeutic effects traditional microneedle patches remain not satisfactory, due to their difficulty simultaneously targeting multiple targets treat wounds. As such, there an urgent need develop a multifunctional (MN) patch for...
This study employed a sophisticated approach consisting of ultrasound-assisted enzyme treatment to extract polysaccharides from sea buckthorn (SBP). The SBP extraction parameters were optimized, the following optimal identified: solid-liquid ratio 1:32 g/mL, ultrasound duration 26 min, temperature 52 °C, and composite concentration 6000 U/100 mL, maximum yield was 24.07 ± 0.15 %. separation purification resulted in isolation three fractions (SBPR-1, SBPR-2, SBPR-3). composition structural...
Nuclear factor erythroid 2-related (Nrf2) confers protection against cell death induced by hyperoxia and other proapoptotic stimuli. Because phosphoinositide-3-kinase (PI3K)/Akt signaling promotes survival, the significance of this pathway in mediating reactive oxygen species (ROS)-dependent hyperoxia-induced Nrf2 activation was investigated murine pulmonary epithelial line, C10. Inhibition PI3K markedly attenuated translocation ARE (antioxidant response element)-mediated transcription....
Neutrophil activation by infectious and inflammatory signals requires ATP release its feedback through purinergic receptors.
Disturbed cell autophagy is found in various cardiovascular disease conditions. Biomechanical stimuli induced by laminar blood flow have important protective actions against the development of vascular diseases. However, impacts and underlying mechanisms shear stress on autophagic process endothelial cells (ECs) are not entirely understood. Here we investigated human ECs. We that flow, but oscillatory or low-magnitude promoted autophagy. Time-course analysis cessation experiments confirmed...
Entecavir (ETV) is a potent inhibitor of hepatitis B viral replication, but long‐term therapy may be required. We investigated whether adding on pegylated interferon (Peg‐IFN) to ETV enhances serological response rates. In this global investigator‐initiated, open‐label, multicenter, randomized trial, e antigen (HBeAg)‐positive chronic (CHB) patients with compensated liver disease started monotherapy (0.5 mg/day) and were in 1:1 ratio either Peg‐IFN add‐on (180 µg/week) from week 24 48 (n =...
High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high associated with nonalcoholic fatty liver disease, which an independent diseases, it remains elusive whether salt-induced hepatic damage leads to development of diseases.Mice were fed normal or high-salt diet 8 weeks determine effect loading on histological changes and blood pressure, withdrawal metformin treatment also conducted some diet-fed mice. Adeno-associated...
Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these thought to differentiate along a common pathway. However, by fate mapping of single NK upon murine cytomegalovirus (MCMV) we identified two distinct cell lineages that contributed responses. One was equivalent conventional (cNK) while the other transcriptionally similar type 1 innate lymphoid (ILC1s). ILC1-like...
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, crosstalk and synovial fibroblasts still largely unknown. Here, global miRNA screening plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total 14 exosomal miRNAs were abnormally expressed RA patients. Then, downregulated expression miR-204-5p confirmed both replication 30:30) validation groups 56:60). Similar to...