A5024194480- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Bone health and treatments
- Gene expression and cancer classification
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Genomics and Rare Diseases
- Evolution and Genetic Dynamics
- Vitamin D Research Studies
- Functional Brain Connectivity Studies
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Genetic Syndromes and Imprinting
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
Tulane University
2016-2025
Xidian University
2025
Peking University
2025
Guangzhou Medical University
2016-2025
Emory University
2024
Boys Town
2024
Boys Town National Research Hospital
2024
HumanN (United States)
2024
Center for Translational Research in Neuroimaging and Data Science
2024
Georgia Institute of Technology
2024
Genetic factors, as well environmental play a role in development of nasopharyngeal carcinoma (NPC). A number single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs ITGA9 at 3p21.3 9 within the 6p21.3 HLA region genotyped. explore potential clinical application markers we further evaluate...
The relationship between obesity and osteoporosis has been widely studied, epidemiological evidence shows that is correlated with increased bone mass. Previous analyses, however, did not control for the mechanical loading effects of total body weight on mass may have generated a confounded or even biased osteoporosis.The objective this study was to reevaluate by accounting mass.We measured whole fat mass, lean percentage index, in two large samples different ethnicity: 1988 unrelated Chinese...
A key assumption in studying mRNA expression is that it informative the prediction of protein expression. However, only limited studies have explored mRNA-protein correlation yeast or human tissues and results been relatively inconsistent. We carried out analyses on expressions freshly isolated circulating monocytes from 30 unrelated women. The expressed proteins for 71 genes were quantified identified by 2-D electrophoresis coupled with mass spectrometry. corresponding Affymetrix gene...
The human gut microbiome can modulate metabolic health and affect insulin resistance, it may play an important role in the etiology of gestational diabetes mellitus (GDM). Here, we compared microbial composition 43 GDM patients 81 healthy pregnant women via whole-metagenome shotgun sequencing their fecal samples, collected at 21-29 weeks, to explore associations between taxonomic units functional genes. A metagenome-wide association study identified 154 837 genes, which clustered into 129...
Abstract Background Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming knowledge-intensive, but essential CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis based on daily analyses. Methods Based a state-of-the-art transfer-learned deep convolutional neural network artificial intelligence (AI), we proposed novel patch aggregation strategy clinic using weakly...
Accurate prognosis for cancer patients can provide critical information optimizing treatment plans and improving life quality. Combining omics data demographic/clinical offer a more comprehensive view of than using or clinical alone also reveal the underlying disease mechanisms at molecular level. In this study, we developed validated deep learning framework to extract from high-dimensional gene expression miRNA conduct prediction breast ovarian-cancer multiple independent multi-omics...
Obesity is a major public health problem with strong genetic determination; however, the factors underlying obesity are largely unknown. In this study, we performed genome-wide association scan for by examining approximately 500 000 single-nucleotide polymorphisms (SNPs) in sample of 1000 unrelated US Caucasians. We identified novel gene, CTNNBL1, which has multiple SNPs associated body mass index (BMI) and fat mass. The most significant SNP, rs6013029, achieved experiment-wise P-values 2.69...
Copy number variation (CNV) has played an important role in studies of susceptibility or resistance to complex diseases. Traditional methods such as fluorescence situ hybridization (FISH) and array comparative genomic (aCGH) suffer from low resolution regions. Following the emergence next generation sequencing (NGS) technologies, CNV detection based on short read data have recently been developed. However, due relatively young age procedures, their performance is not fully understood. To...
Abstract To understand the role of environmental and genetic influences on nasopharyngeal carcinoma (NPC) in populations at high risk NPC, we have performed a case‐control study Guangxi Province Southern China 2004–2005. NPC cases ( n = 1,049) were compared with 785 NPC‐free matched controls who seropositive for IgA antibodies (IgA) to Epstein‐Barr virus (EBV) capsid antigen (VCA)—a predictive marker Chinese populations. A questionnaire was used capture exposure family history data. Risk...
The human zona pellucida is composed of four glycoproteins (ZP1, ZP2, ZP3, and ZP4) has an important role in reproduction. Here we describe a form infertility with autosomal recessive mode inheritance, characterized by abnormal eggs that lack pellucida. We identified homozygous frameshift mutation ZP1 six family members. In vitro studies showed defective proteins normal ZP3 colocalized throughout the cells were not expressed at cell surface, suggesting aberrant results sequestration...
Abstract Motivation: Several new de novo assembly tools have been developed recently to assemble short sequencing reads generated by next-generation platforms. However, the performance of these under various conditions has not fully investigated, and sufficient information is currently available for informed decisions be made regarding tool that would most likely produce best a specific set conditions. Results: We studied compared commonly used specifically designed data, including SSAKE,...