A5000151117- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Advanced Neural Network Applications
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Research Studies
- Machine Learning and Data Classification
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2016-2025
Fudan University
2015-2025
Anhui University of Traditional Chinese Medicine
2025
West China Hospital of Sichuan University
2024
Sichuan University
2017-2024
Beijing Institute of Technology
2022-2024
Zhangzhou Municipal Hospital of Fujian Province
2024
Fujian Medical University
2024
Sun Yat-sen University
2022-2024
MicroRNA (miRNA) opens up a new field for molecular diagnosis of cancer. However, the role circulating miRNAs in plasma/serum cancer is not clear. The aim this study was to investigate whether plasma can be used as biomarkers early detection colorectal carcinoma (CRC). We measured levels 12 (miR-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) samples from patients with advanced neoplasia (carcinomas adenomas) healthy controls using real-time RT-PCR. found that...
Purpose: The long, noncoding RNA (lncRNA) PVT1 is an important epigenetic regulator with a critical role in human tumors. Here, we aimed to investigate the clinical application and potential molecular mechanisms of gastric cancer tumorigenesis progression.Experimental Design: expression level was determined by RT-qPCR analysis 190 pairs tissues adjacent normal mucosa (ANT). biologic functions were assessed vitro vivo functional experiments. protein pull-down assays LS/MS mass spectrometry...
Colorectal cancer (CRC) is a major cause of death worldwide. Sensitive, non-invasive diagnostic screen methods are urgently needed to improve its survival rates. Stable circulating microRNA offers unique opportunities for the early diagnosis several diseases, including cancers. Our aim has been find new plasma miRNAs that can be used as biomarkers detection CRC.According results miRNA profiling performed on pooling samples form 10 CRC patients or healthy controls, panel (hsa-miR-10a, -19a,...
Long noncoding RNA (lncRNA) and mRNAs are long RNAs (≥200 nucleotides) compared with miRNAs. In blood, may be protected by serum extracellular vesicles, such as apoptotic bodies (AB), microvesicles (MV), exosomes (EXO). They potential biomarkers for identifying cancer.Sera from 76 preoperative colorectal cancer patients, age- sex-matched healthy subjects, 20 adenoma patients without were collected. We investigated the distribution of into three vesicles. Seventy-nine cancer-related chosen...
Abstract Background Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming knowledge-intensive, but essential CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis based on daily analyses. Methods Based a state-of-the-art transfer-learned deep convolutional neural network artificial intelligence (AI), we proposed novel patch aggregation strategy clinic using weakly...
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
PURPOSE To assess whether the integration of PD-1 inhibitor with total neoadjuvant therapy (iTNT) can lead to an improvement in complete responses (CRs) and favors a watch-and-wait (WW) strategy patients proficient mismatch repair or microsatellite stable (pMMR/MSS) locally advanced rectal cancer (LARC). PATIENTS AND METHODS We conducted prospective, multicenter, randomized, open-label, phase II trial using pick-the-winner design. Eligible clinical T3-4 and/or N+ adenocarcinoma were randomly...
The examination of circulating nucleic acids (CNAs) is an emerging noninvasive diagnostic technique. However, it unclear if serum long noncoding RNAs (lncRNAs) represent a novel marker to detect gastric cancer (GC). In this study, we measured 39 candidate cancer‐associated lncRNAs by reverse transcription and quantitative polymerase chain reaction (RT‐qPCR) in sera from 110 patients with GC, 106 age‐ sex‐matched healthy subjects 15 peptic ulcer, markers were validated assessed RT‐qPCR....
Abstract Background The long non-coding RNAs (lncRNAs) study has gradually become one of the hot topics in field RNA biology. One lncRNA which attracted attention is LOC285194, a demonstrated potential tumor-suppressor role osteosarcoma. aim this was to examine expression LOC285194 colorectal cancer (CRC) patients and investigate relationship between levels existing clinicopathologic parameters patient survival. Methods detected by quantitative real-time polymerase chain reaction pairs...
Epstein-Barr virus-associated gastric cancer (EBVaGC) shows a robust response to immune checkpoint inhibitors. Therefore, cost-efficient and accessible tool is needed for discriminating EBV status in patients with cancer. Here we introduce deep convolutional neural network called EBVNet its fusion pathologists predicting EBVaGC from histopathology. The yields an averaged area under the receiver operating curve (AUROC) of 0.969 internal cross validation, AUROC 0.941 on external dataset...
Label noise has been a practical challenge in deep learning due to the strong capability of neural networks fitting all training data. Prior literature primarily resorts sample selection methods for combating noisy labels. However, these approaches focus on dividing samples by order sorting or threshold selection, inevitably introducing hyperparameters (e.g., ratio / threshold) that are hard-to-tune and dataset-dependent. To this end, we propose simple yet effective approach named PNP...
Abstract Tertiary lymphoid structures (TLSs) have been associated with favorable immunotherapy responses and prognosis in various cancers. Despite their significance, quantification using multiplex immunohistochemistry (mIHC) staining of T B lymphocytes remains labor-intensive, limiting its clinical utility. To address this challenge, we curated a dataset from matched mIHC H&E whole-slide images (WSIs) developed deep learning model for automated segmentation TLSs. The achieved Dice...
Recently, long noncoding RNAs (lncRNAs) were demonstrated to play important regulatory roles in biological processes and cancer biology. However, the overall pathophysiological contribution of lncRNAs gastric (GC) remains largely unknown. In this study, differentially expressed GC paired adjacent normal tissue samples identified by microarray validated using quantitative real-time polymerase chain reaction (qRT-PCR). One particular lncRNA, tumour suppressor candidate 7 (TUSC7), was analyzed...
Liver metastasis is common in patients diagnosed with colorectal cancer (CRC), and also correlated poor outcome. In this study we screened the different expression profiles of microRNAs (miRNAs) on development liver CRC patients. miR-99b-5p was found to be more than 6-fold higher primary tumors matched metastases (P = 0.007). Expression stage III without 0.028). Up-regulated associated longer overall survival 0.01). Besides, silencing miR-99b-5p-positive cell lines promoted migration...
Objectives Except pancreatic adenocarcinoma, cancer has several uncommon histological subtypes, including invasive intraductal papillary mucinous neoplasm (IPMN), neuroendocrine tumor (pNET), adenosquamous carcinoma, cystic (MCN), acinar cell carcinoma (ACC), squamous (SCC), and solid pseudopapillary (SPT). However, features of theses subtypes are not systematically analyzed. Methods Subjects with different cancers were retrieved from the Surveillance, Epidemiology, End Results registry....
Undifferentiated carcinoma of the gastrointestinal tract has variable rhabdoid features. Expression switch/sucrose nonfermenting (SWI/SNF) complex subunits is reportedly lost in a portion cases; however, prognostic significance this loss remains unknown. Herein, 30 undifferentiated cases were assessed for expression 4 SWI/SNF (SMARCB1, SMARCA2, SMARCA4, and ARID1A). Tumor origin sites comprised stomach (40.0%), large intestine (20.0%), small (16.7%), lower esophagus fundus (13.3%), ileocecal...
Uterine tumor resembling ovarian sex cord (UTROSCT) is a rare mesenchymal neoplasm that mainly harbors NCOA1-3 rearrangements with partner genes ESR1 or GREB1 . Here, we explored 23 UTROSCTs by targeted RNA sequencing. The association between molecular diversity and clinicopathologic features was investigated. mean age of our cohort 43 years (23-65 y). Only 15 patients (65%) were originally diagnosed UTROSCTs. Mitotic figures ranged from 1 to 7/10 high power fields, primary tumors increased...
The authors' purpose was to explore the incidence and prognostic significance of perineural invasion (PNI) in pT3N0 rectal cancer.Pathologic materials from resected specimens 173 patients with cancer were retrospectively collected. PNI-positivity categorized into 2 groups: surrounding nerve sheath (SS-PNI) invading through (TS-PNI). rate compared PNI as initially recorded original reports. Patients' outcome studied groups different status, multivariate analysis performed determine its...
Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) play critical roles in regulating cellular processes, such as cell growth and apoptosis, well cancer progression metastasis. ncRAN (non-coding RNA expressed aggressive neuroblastoma) was previously shown to be dramatically up-regulated associated with poor prognosis human neuroblastoma. This lncRNA also plays an important role bladder invasion. Colorectal (CRC) typically follows a complex cascade from primary malignancy...