A5004567240- Liver physiology and pathology
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Radiopharmaceutical Chemistry and Applications
- Thyroid Disorders and Treatments
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Ear and Head Tumors
- Soft tissue tumors and treatment
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Colorectal and Anal Carcinomas
- CNS Lymphoma Diagnosis and Treatment
Shanghai Jiao Tong University
2017-2025
Renji Hospital
2015-2025
Xidian University
2025
Memorial Sloan Kettering Cancer Center
2018-2024
Tsinghua University
2022-2024
Fudan University Shanghai Cancer Center
2014-2024
Shihezi University
2023
Shanghai Medical College of Fudan University
2015-2018
Fudan University
2015-2017
Jinshan Hospital of Fudan University
2013-2015
Histone deacetylase 5 (HDAC5) is an important protein in neural and cardiac diseases a potential drug target. However, little known regarding the specific role of HDAC5 breast cancer (BC). We aimed to evaluate expression human tumors determine effects inhibition BC cells.HDAC5 was evaluated patients correlated with clinical features patient prognosis. Functional experiments were performed using shRNA selective HDAC inhibitor LMK-235 for knockdown cells. The synergistic proteasome bortezomib...
Uterine tumor resembling ovarian sex cord (UTROSCT) is a rare mesenchymal neoplasm that mainly harbors NCOA1-3 rearrangements with partner genes ESR1 or GREB1 . Here, we explored 23 UTROSCTs by targeted RNA sequencing. The association between molecular diversity and clinicopathologic features was investigated. mean age of our cohort 43 years (23-65 y). Only 15 patients (65%) were originally diagnosed UTROSCTs. Mitotic figures ranged from 1 to 7/10 high power fields, primary tumors increased...
Abstract Purpose: Oncogenic fusions involving the neuregulin 1 (NRG1) gene are found in approximately 0.2% of cancers diverse histologies. The resulting chimeric NRG1 proteins bind predominantly to HER3, leading HER3-HER2 dimerization and activation downstream growth survival pathways. HER3 is, therefore, a rational target for therapy fusion–driven cancers. Experimental Design: We developed novel patient-derived isogenic models NRG1-rearranged examined effect anti-HER3 antibody,...
Chondroitin polymerizing factor (CHPF) is an important glycosyltransferase involved in the biosynthesis of chondroitin sulfate. However, relationship between CHPF and gastric cancer has not been fully investigated. expression tissues was detected by immunohistochemistry correlated with patient prognosis. Cultured cells human epithelial cell line GES1 were used to investigate effects shCHPF shE2F1 on development progression MTT, western blotting, flow cytometry analysis apoptosis, colony...
Desmoplastic small round cell tumor (DSRCT) is a rare but highly aggressive soft tissue sarcoma that arises in the abdominopelvic cavity of young males. Since discovery EWSR1::WT1 fusion as driver DSRCT, no actionable genomic alterations have been identified, limiting disease management to combination surgery, chemotherapy, and radiation, with very poor outcomes. Herein, we evaluated ERBB2/HER2 expression DSRCT therapeutic target.
Abstract Purpose: BATF2, a novel IFN-stimulated gene, inhibits tumor cell proliferation, invasion, and migration. The objectives of this study were to determine how BATF2 expression is associated with colorectal cancer progression patient outcome, investigate overexpression hepatocyte growth factor (HGF)/MET signaling, elucidate the rationale for combining MET inhibitors IFN. Experimental Design: in tissues was determined correlated prognosis. Cultured cells used effects on malignant...
Objective: To detect ROS1 rearrangement using three different assays, including immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and reverse transcription polymerase chain reaction (RT-PCR), to analyze the clinicopathologic features of patients with lung adenocarcinoma. Methods: One hundred eighty-three consecutive adenocarcinoma operation follow-up data were analyzed for by IHC, FISH, RT-PCR. PCR products RT-PCR-positive samples sequenced confirmation specific fusion...
It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role pathway. However, copy number variations (CNVs) of subunits on gene level remain unknown DLBCL. Therefore, aim study to investigate CNV and their relationship with clinicopathological features exploring possible mechanism underlying 12 genes was detected by NanoString nCounter 60 de novo DLBCLs 10 reactive hyperplasia specimens as...
The resistance of cancer cells to apoptosis poses a significant challenge in therapy, driving the exploration alternative cell death pathways such as pyroptosis, known for its rapid and potent effects. While initial efforts focused on chemotherapy‐induced concerns about systemic inflammation highlight need precise activation strategies. Photothermal therapy emerges promising non‐invasive technique, minimizing pyroptosis‐related side effects by targeting tumors spatially temporally. However,...
Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin's with limited data. In this study, population-based study of primary DLBCL in the United States was performed to determine its incidence trends, prognostic factors, survival, role surgery as well comparison nodal DLBCL. 1021 patients diagnosed were identified Surveillance, Epidemiology, and End Results (SEER) cancer registries from 1973-2014. The both increased over time. Patients older, mainly women, at earlier...
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses transcriptional regulatory domain of EWSR1 with DNA-binding WT1, resulting in oncogenic EWSR1-WT1 fusion protein. The paucity DSRCT disease models has hampered preclinical therapeutic studies on this aggressive cancer. Here, we developed and mined expression profiles to identify genetic vulnerabilities that could be leveraged for new therapies. We describe four lines one...
Abstract Background Considering the molecular heterogeneity of sarcomas and their immunologically quiet character, immunotherapy (e.g., immune checkpoint inhibitors) plays a viable role in only subset these tumors. This study aimed to determine subtypes (IMSs) for selecting suitable patients from an extremely heterogeneous population. Results By performing consensus clustering analysis gene expression profiles 538 with online databases, we stratified into three IMSs characterized by...
Primary gastric adenosquamous carcinoma (GASC) is a rare tumor that exhibits aggressive behavior and currently lacks standardized therapeutic recommendations. Microsatellite instability (MSI)/mismatch repair deficiency (dMMR) positive PD-L1 expression confer sensitivity to immune checkpoint inhibitors; however, their statuses in GASC remain uncertain. In this study, clinical features, MMR/MSI status, MLH1 methylation, two T-cell markers, of 30 cases were collected from three institutions....
4197 Background: Primary duodenal adenocarcinoma (DA) is a rare gastrointestinal tumor with poor prognosis. This study aimed to investigate the immune microenvironment (TIME) and genetic landscape of DA depict unique subtypes, distinguishing its prognosis identifying potential therapeutic targets. Methods: To reveal heterogeneity DA’s TIME, 88 treatment-naïve samples were analyzed via multiplex immunofluorescence (mIF) staining, whole-exome sequencing, RNA sequencing. The quantity...
e16472 Background: Primary duodenal adenocarcinoma (DA) is a rare tumor with low incidence rate, high mortality and lacks effective treatment methods sensitive biomarkers for predicting prognosis. We aim to analyze the differences in clinical characteristics between Chinese Western populations DA, construct model better predict prognosis of patients DA. Methods: 500 DA from SEER database 232 Renji Hospital, Shanghai Jiaotong University school were enrolled. A nomogram was constructed...
Indolent natural killer (NK) cell lymphoproliferative disorder of the gastrointestinal (GI) tract (iNKLPD) is a rare, recently recognised neoplasm. Most reported tumours are confined to GI tract, while small subset harbour JAK3 mutations. We collected four cases iNKLPD with goal adding additional information current knowledge this disease regarding clinicopathological, immunohistochemical and molecular features.Similar features including medium- large-sized lymphoid cells variable amounts...
Several clinical and pathological factors have an impact on the prognosis of colorectal cancer (CRC), but they are not yet adequate for risk assessment. We aimed to identify a molecular signature that can reliably CRC patients at high recurrence.Two hundred eighty-one samples (stage II/III) were included in this study. A two-step gene expression profiling study was conducted. First, measurements from 81 fresh frozen obtained using Affymetrix Human Genome U133 Plus 2.0 Arrays. Second, focused...
Abstract Some histone deacetylases (HDACs) promote tumor cell growth and pan‐ or selective HDAC inhibitors are active in some cancers; however, the pivotal enzyme its functions human diffuse large B‐cell lymphoma (DLBCL) remain largely unknown. Using NanoString nCounter assays, we profiled mRNA expression identified HDAC6 as an upregulated family member DLBCL tissue samples. We then found that plays oncogenic role DLBCL, evidenced by promotion of proliferation vitro xenograft vivo ....
Xiaolin Lin, Ting Han, Meng Zhuo, Tengfei Liu, Zebing Dongxi Xiang, Hong Li, Xiuying Xiao
Background: Direct liver invasion (DI) is a predominant pathway of gallbladder cancer (GBC) metastasis, but the molecular alterations associated with DI remain addressed.This study identified specific genes correlated DI, which may offer potential biomarker for diagnosis and prognosis advanced GBC.Methods: RNA samples from 3 patients GBC were used RNA-seq analysis.Differentially expressed metabolic pathways between primary tumor (T) tissue was to analyze aberrant gene...
Despite intensive efforts, a considerable proportion of colorectal cancer (CRC) patients develop local recurrence and distant metastasis. Stomatin-like protein 2 (SLP-2), member the highly conserved stomatin superfamily, is upregulated across types. However, biological functional roles SLP-2 remain elusive in CRC. Here, we report that high expression was found CRC tissues linked to tumor progression cell differentiation. Additionally, correlated with poor overall survival (OS) (p < 0.001)....