A5045032713- Sarcoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Soft tissue tumors and treatment
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Tumors and Oncological Cases
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Photonic and Optical Devices
- Platelet Disorders and Treatments
- Complement system in diseases
- Ubiquitin and proteasome pathways
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Neurofibromatosis and Schwannoma Cases
- Power Systems Fault Detection
- Multiple Myeloma Research and Treatments
- Soft tissue tumor case studies
Regeneron (United States)
2023-2025
Memorial Sloan Kettering Cancer Center
2011-2023
Kettering University
2018
Pediatrics and Genetics
2013-2017
Cornell University
2014
We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657 pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally utilize transcriptomes 131 cell lines 147 normal tissue for comparison. describe patterns infiltrating immune cells, T receptor (TCR) clonal expansion, translationally relevant checkpoints. find that tumor-infiltrating lymphocytes TCR counts vary widely across types within each diagnosis, notably are significantly...
Desmoplastic small round cell tumor (DSRCT) was proposed as a distinct disease entity by William L Gerald and Juan Rosai in 1991. Over 850 patients have been reported the medical literature. A specific translocation, t(11;22)(p13;q12), is seen almost all cases, juxtaposing EWS gene to WT1 suppressor gene. DSRCT composed of nests cells with polyphenotypic differentiation, typically mixture epithelial, mesenchymal neural features, surrounded prominent desmoplastic stroma. has predilection for...
Ewing Sarcoma (ES) and Desmoplastic Small Round Cell Tumors (DSRCT) are aggressive sarcomas molecularly characterized by EWSR1 gene fusions. As pathognomonic genomic events in these respective tumor types, fusions represent robust potential biomarkers for disease monitoring.To investigate the feasibility of identifying plasma derived cell-free DNA (cfDNA) from ES DSRCT patients, we evaluated two complementary approaches samples 17 patients with radiographic evidence disease. The first...
Abstract Background Children, adolescents, and young adults treated for Ewing sarcoma (ES) are at risk disease‐related treatment‐related complications. We aimed to describe early late overall mortality, cause‐specific key adverse health outcomes in a large, single‐institutional cohort of patients with ES. Methods Patients ES diagnosed age less than 40 years Memorial Sloan Kettering between 1974 2012 were included. Overall survival was estimated using Kaplan–Meier methods. Cox proportional...
Background The role, optimal dose, and efficacy of radiotherapy (RT) for the treatment bone metastases in rhabdomyosarcoma (RMS) Ewing sarcoma (ES) are unclear. Procedure All patients with ES or RMS who received RT curative intent during frontline therapy at Memorial Sloan Kettering Cancer Center (MSKCC) between 1995 2013 were reviewed. Among 30 (8 22 ES), 49 irradiated. Results Median biologically effective dose (BED) was 42.4 Gy (range, 34.9–59.7) 50.7 31.3–65.8) ES. Tumor recurrence...
Abstract Purpose: Desmoplastic small round cell tumor (DSRCT) is a highly lethal intra-abdominal sarcoma of adolescents and young adults. DSRCT harbors t(11;22)(p13:q12) that generates the EWSR1-WT1 chimeric transcription factor, key oncogenic driver DSRCT. rewires global gene expression networks activates aberrant targets together mediate oncogenesis. also neural program. Experimental Design: Among these markers, we found prominent neurotrophic tyrosine kinase receptor 3 (NTRK3), druggable...
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses transcriptional regulatory domain of EWSR1 with DNA-binding WT1, resulting in oncogenic EWSR1-WT1 fusion protein. The paucity DSRCT disease models has hampered preclinical therapeutic studies on this aggressive cancer. Here, we developed and mined expression profiles to identify genetic vulnerabilities that could be leveraged for new therapies. We describe four lines one...
OBJECTIVE. The purpose of this study was to determine whether methylene diphosphonate (MDP) bone scans are necessary during initial staging in patients with Ewing sarcoma (ES) whom 18F-FDG PET/CT is performed.
Desmoplastic small round cell tumor (DSRCT), a rare, aggressive neoplasm, has poor prognosis. In this prospective study, we evaluated the role of myeloablative chemotherapy, followed by autologous stem transplant in improving survival DSRCT. After high-dose induction chemotherapy and surgery, 19 patients with chemoresponsive DSRCT underwent transplant. Myeloablative consisted carboplatin (400-700 mg/m(2)/day for 3 days) + thiotepa (300 ± topotecan (2 5 days). All were engrafted there was no...
Background Outcomes for patients with metastatic Ewing sarcoma (ES) remain poor. We investigated whether the intensification of ifosfamide improved survival ES. Procedure conducted a retrospective chart review 30 ES treated MSKCC "EFT regimen." The regimen included an dosing from 1,800 mg/m2/day × 5 days per cycle to 2,800 cycle. Results Twenty six completed planned chemotherapy. Two experienced disease progression during therapy. There were no toxic deaths. One patient developed secondary...
Abstract Undifferentiated embryonal sarcoma of the liver (UESL) is a rare aggressive mesenchymal pediatric tumor. Previously, reported outcomes have been very poor. Here, we report single‐center experience five patients with UESL treated upfront gross total resection and adjuvant chemotherapy. We median follow‐up 8 years range from 5 to 19 100% event‐free survival.
Gastrointestinal stromal tumours (GIST) are rarely encountered mesenchymal of the gastrointestinal tract (1.5 people per 100,000/year) that even more seen in paediatric patients (1–2% all cases). The standard treatment for advanced adult GIST is imatinib with sunitinib as a second-line option. Although efficacy and tolerability adults has been established, little known profile paediatric/young given rarity this disease. Paediatric/young aged up to 21 years diagnosis who were treated...
Desmoplastic small round cell tumors (DSRCT) typically have a large stromal component and often are extensively disseminated in the peritoneal cavity at diagnosis. These factors contribute to difficulty quantifying response chemotherapy using RECIST or WHO criteria. This study compares overall disease by fluorodeoxyglucose-positron emission tomography (FDG-PET) computed (CT) patients with DSRCT.We conducted retrospective chart review of 7 DSRCT who were imaged FDG-PET CT diagnosis after 3...
Histologic response to preoperative chemotherapy is a strong prognostic factor for osteosarcoma (OS). Thallium-201 (Tl-201) scintigraphic initial has previously been described as predictor of histologic response. In the current study, authors re-examined series patients studied using Tl-201 scintigraphy determine correlation between changes observed on and event-free survival (EFS).A total 22 with biopsy-proven OS extremity underwent imaging before immediately after chemotherapy. The maximum...
Multifocal osteosarcoma is usually defined as the occurrence of a tumor at 2 or more sites in patient without pulmonary metastases and may be synchronous with than one lesion seen presentation metachronous new tumors developing after initial treatment. It difficult to determine whether these represent multiple primary lesions metastases. We present rare case widespread multifocal brief review literature.
Abstract We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented hepatic venous thromboses subsequently developed splenic infarction rupture requiring splenectomy while on anticoagulation therapy for the thromboses. The patient's was complicated by heparin‐induced thrombocytopenia (HIT) highlighting unique management challenge PNH in combination HIT. Pediatr Blood Cancer 2009;53:472–474. © 2009 Wiley‐Liss, Inc.