A5100748351- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Autophagy in Disease and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- AI in cancer detection
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Advanced Neuroimaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Alzheimer's disease research and treatments
- Prostate Cancer Treatment and Research
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Sarcoma Diagnosis and Treatment
- Asthma and respiratory diseases
- PARP inhibition in cancer therapy
Johns Hopkins University
2025
Shanghai University of Medicine and Health Sciences
2017-2025
Shanghai Jiao Tong University
2012-2025
Renji Hospital
2012-2025
Jiading District Central Hospital
2022-2025
South China University of Technology
2025
Zunyi Medical University
2024
Qilu Hospital of Shandong University
2024
Southwest Medical University
2024
Shanghai University of Traditional Chinese Medicine
2024
Methionine metabolism is critical for epigenetic maintenance, redox homeostasis, and animal development. However, the regulation of methionine remains unclear. Here, we provide evidence that SIRT1, most conserved mammalian NAD+-dependent protein deacetylase, critically involved in modulating metabolism, thereby impacting maintenance mouse embryonic stem cells (mESCs) subsequent embryogenesis. We demonstrate SIRT1-deficient mESCs are hypersensitive to restriction/depletion-induced...
Purpose Pulmonary nodules are a potential manifestation of lung cancer. In computer‐aided diagnosis (CAD) cancer, it is great significance to extract the complete boundary pulmonary in computed tomography (CT) scans accurately. It can provide doctors with important information such as tumor size and density, which assist subsequent treatment. addition this, molecular subtype radiomics segmentation also plays pivotal role. Existing methods difficult use only one model simultaneously treat...
Diabetes and obesity are established risk factors for heart failure(HF). Although the TyG (triglyceride-glucose) index serves as a sensitive marker identifying insulin resistance, there is lack of comprehensive evidence regarding whether its integration with indices can enhance predictive capacity HF. This prospective cohort study designed to explore correlation between in conjunction (TyG-body mass index, or TyG-BMI; TyG-waist circumference, TyG-WC; circumference-to-height ratio, TyG-WHtR)...
To design an ensemble learning based prediction model using different breast DCE-MR post-contrast sequence images to distinguish two kinds of cancer subtypes (luminal and non-luminal). We retrospectively studied preoperative dynamic contrast enhanced-magnetic resonance imaging molecular information 266 cases with either luminal subtype A B) or non-luminal (human epidermal growth factor receptor 2 triple negative). Then, multiple bounding boxes covering tumor lesions were acquired from three...
Respiratory oscillometry is a promising complement to the traditional pulmonary function tests for its simplicity. The usefulness of in adult clinical practice has not been clarified. This study aimed analyse characteristics and diagnostic performance respiratory diseases, explore cut-offs oscillometric parameters severity grading.In this multicentre registry impulse (IOS), IOS spirometric data healthy individuals patients with diseases were collected analysed. Linear mixed model analysis...
Combination chemotherapy is a potentially promising approach to enhance anticancer activity, overcome drug resistance, and improve disease-free overall survival. The current study investigates the antitumor activity of sodium dichloroacetic acid (DCA) in combination with SIRT2 inhibitor Sirtinol AGK2. We found that combining DCA produced synergistic therapeutic benefit A549 H1299 NSCLC cells vitro mouse xenograft model. Synergistic potentiation oxidative phosphorylation (OXPHOS) was...
To enhance the affinity of peptide ligands for their targets, covalent warheads can be engineered to facilitate irreversible binding. This study aimed at exploring potential a 68Ga-labeled peptidomimetic radioligand, [68Ga]Ga-DOTA-RQAR-kbt, PET imaging through its binding suppression tumorigenicity 14 (ST14). An Arg-Gln-Ala-Arg (RQAR) tetrapeptide was conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid gallium-68 radiolabeling. The warhead ketobenzothiazole constructed...
A leaf-inspired double-layer membrane was designed, exhibiting 99.3% solar reflectivity and ∼95% mid-infrared emissivity. It remained stable under 7000 MJ m −2 ultraviolet radiation, presenting a new strategy for passive radiative cooling.
Background Hypoxia is associated with the evasion of triple-negative breast cancer (TNBC) from immune surveillance. increases subpopulation putative TNBC stem-like cells (TNBCSCs) through activating Wnt/β-Catenin signaling. The shedding MHC class I-related chain A (MICA) particularly noteworthy in stem (CSCs), promoting resistance CSCs to natural killer (NK) cell cytotoxicity. To reestablish MICA/NKG2D-mediated immunosurveillance, we proposed design a fusion protein (SHH002-hu1-MICA) which...
In order to assist doctors in arranging the postoperative treatments and re-examinations for non-small cell lung cancer (NSCLC) patients, this study was initiated explore a prognostic analysis method NSCLC based on computed tomography (CT) radiomics. The data of 173 patients were collected retrospectively clinically meaningful 3-year survival used as predictive limit predict patient's prognosis time range. Firstly, tumors segmented radiomics features extracted. Secondly, feature weighting...
The goal of this study was to investigate whether the combined PET/CT radiomic features primary tumor and lymph node could predict metastasis (LNM) resectable non-small cell lung cancer (NSCLC) in stage T2-4.This retrospective included 192 NSCLC patients who underwent dissection between August 2016 December 2017 18F-fluorodeoxyglucose (18F-FDG) scanning 1-3 weeks before surgery. In total, tumors (> 3 cm) 462 nodes (LN > 0.5 were analyzed. pretreatment clinical these recorded, their extracted...
To assist clinicians in arranging personalized treatment, planning follow-up programs and extending survival times for non-small cell lung cancer (NSCLC) patients, a method of deep learning combined with computed tomography (CT) imaging prediction was designed.Data were collected from 484 patients four research centers. The data 344 utilized to build the A_CNN prognosis model classify 2-year overall time ranges (730 days cut-off). Data 140 including independent internal external test sets,...
To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy rats primary hepatocellular carcinomas (HCCs) a full spectrum differentiation and vascularity by magnetic resonance imaging (MRI), microangiography histopathology. Ninety-six HCCs were raised 25 diethylnitrosamine gavage. Tumor growth was monitored T2-/T1-weighted-MRI (T2WI, T1WI)...
Purpose:To demonstrate the relationship between etiologies of increased diffuse bone marrow (BM) 18 F-FDG uptake and PET/CT imaging/clinical features, as well to explore a predicting model BM malignant infiltration (MI) based on decision tree.Methods: 84 patients with were retrospectively enrolled.Their complete case record images reviewed, maximal standardized values (SUVmaxBM) other features noted.At same time, differences in MI non-MI groups compared.The tree for was established by C5.0...