A5039351764- Redox biology and oxidative stress
- Signaling Pathways in Disease
- Psoriasis: Treatment and Pathogenesis
- Nonmelanoma Skin Cancer Studies
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Cervical Cancer and HPV Research
- Heat shock proteins research
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Mass Spectrometry Techniques and Applications
- Enzyme function and inhibition
- Cytokine Signaling Pathways and Interactions
- Sulfur Compounds in Biology
- Nanoplatforms for cancer theranostics
- Ear Surgery and Otitis Media
- Immune cells in cancer
- Galectins and Cancer Biology
- Nasal Surgery and Airway Studies
- Melanoma and MAPK Pathways
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Biological Stains and Phytochemicals
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics, phytochemicals, and oxidative stress
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Jiading District Central Hospital
2023-2025
Shanghai University of Medicine and Health Sciences
2023-2025
Hunan Cancer Hospital
2019-2023
University of Shanghai for Science and Technology
2023
Chongqing Three Gorges University
2023
Beihang University
2019
Hebei Medical University
2019
Fourth Hospital of Hebei Medical University
2019
Psoriasis is an immune-mediated chronic inflammatory skin disease. Although its pathogenesis not fully understood, Th17 cells and the cytokines they produce, such as IL-17, IL-22 IL-23, play critical roles in of psoriasis. Evidence has demonstrated that psoriasis some common features, including immune responses (due to cells) cytokine profiles, with systematic diseases bowel (IBDs) obesity. Recently, studies have gut microbiota plays a crucial role host homoeostasis response, particular...
Abstract Keloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed optimize treatment protocols. However, biophysical mechanisms have not yet been fully elucidated. Here, it proposed piezo‐type mechanosensitive ion channel component 1 (Piezo1) plays an important role in low‐frequency sonophoresis (LFS) induced mechanical transduction...
The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating and ATP in the glycolytic pathway, whereas role PKM2 tumorigenesis remains subject debate. In our study, we found highly expressed melanoma patients malignance positively correlated with high activity capability cells. Suppression expression by knocking down markedly attenuated malignant phenotype both vitro vivo, restoration depleted cells could rescue proliferation, invasion metastasis. With data indicating as...
Crosslinked P(MMA-BA)–CNTs shape memory composites prepared by ultrasound assisted in situ polymerization, have both relatively high electrical conductivities and good properties. Electrical resistance heating was used as a trigger to realize the spatial temporal control of process obtain multiple shapes selecting place where voltage applied or switching power on/off.
// Zhongling Luo 1 , Xu Zhang Weiqi Zeng Juan Su Keda Yang 2 Lixia Lu Chuan Bian Lim 3 Wen Tang 4 Lisha Wu 5 Shuang Zhao Xuekun Jia Cong Peng Xiang Chen Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China Pathology, Genetics and Complex Diseases, Harvard T.H. Chan School Public Health, Boston, MA, USA Geriatrics, Institute Medical Science Research, Correspondence to: Peng, e-mail: pengchongpeng@hotmail.com Chen, chenxiangck@126.com Keywords: TRAF6,...
Abstract Sulfiredoxin (SRXN1/Srx) is a multifunction enzyme with primary antioxidant role of reducing the overoxidized inactive form peroxiredoxins (Prxs). The function and mechanisms Srx in cancer development are not well understood. Here, preferentially expressed human colorectal cells but normal colon epithelial cells. Loss-of-function studies demonstrate that knockdown poorly differentiated only leads to inhibition colony formation cell invasion vitro, also reduces tumor xenograft growth...
Non-small-cell lung cancer (NSCLC) is one of the deadliest cancers worldwide, and metastasis considered leading causes treatment failure in NSCLC. Wnt/β-catenin signaling crucially involved epithelial-mesenchymal transition (EMT), a crucial factor promoting metastasis, also contributes to resistance developed by NSCLC targeted agents. Frizzled-7 (Fzd7), critical receptor signaling, aberrantly expressed has been confirmed be positively correlated with poor clinical outcomes. SHH002-hu1,...
Abstract CD200 is a cell surface glycoprotein that functions through engaging CD200R on cells of the myeloid lineage and inhibits their functions. Expression was implicated in variety human cancer cells, including melanoma cells; however, its roles tumor growth immunity are not clearly understood. In this study, we used CD200R-deficient mice B16 model to evaluate issue. We found exhibited accelerated CD200+, but CD200−, tumors. Strikingly, receiving CD200+ i.v. massive multiple organs,...
Melanoma is a very malignant disease and there are still no effective treatments. CD147 participates in the carcinogenesis of multiple human cancers GLUT-1, as glucose transporter, associated with tumor growth. However, function GLUT-1 melanoma have not been completely understood. Thus, this study we investigated expression tissue, which were overexpressed compared that nevus tissue. In addition, co-localized cytoplasm A375 cells. Immunoprecipitation proved interacted at D105-199. Silencing...
Abstract Background Melanoma is one of the most aggressive tumors with remarkable characteristic resistance to traditional chemotherapy and radiotherapy. Although targeted therapy immunotherapy benefit advanced melanoma patient treatment, BRAFi (BRAF inhibitor) lower response rates or severe side effects have been observed, therefore, it necessary develop novel inhibitors for treatment. Methods We detected cell proliferation lj-1-59 in different cells by CCK 8 colony formation assay. To...
Mohs micrographic surgery (MMS) is the preferable for difficult -to-treat basal cell carcinoma (BCC) but an expensive, labor-intensive, and time-consuming technique. The aim of this study to compare efficacy safety photodynamic therapy combined with surgery(S-PDT) versus treatment difficult-to-treat BCC.This was a retrospective, comparative study. A total 32 patients, 16 patients 48 lesions, were treated S-PDT, other 17 lesions by MMS enrolled in Follow-up at least 36 months...
Background Hypoxia is associated with the evasion of triple-negative breast cancer (TNBC) from immune surveillance. increases subpopulation putative TNBC stem-like cells (TNBCSCs) through activating Wnt/β-Catenin signaling. The shedding MHC class I-related chain A (MICA) particularly noteworthy in stem (CSCs), promoting resistance CSCs to natural killer (NK) cell cytotoxicity. To reestablish MICA/NKG2D-mediated immunosurveillance, we proposed design a fusion protein (SHH002-hu1-MICA) which...
This study was conducted to identify the risk of residual or recurrent high-grade squamous intraepithelial lesions worse (HSIL+) in patients with successful conization and develop a customized management strategy. retrospective included 939 who underwent cold knife (CKC) for cervical neoplasia 3 at hospital China between January 1, 2013 December 31, 2020. Demographic characteristics test results were obtained before 6, 12, 24 months after CKC annually thereafter. Human papillomavirus (HPV)...
TRAF6, a well-known adapter molecule, plays pivotal role in TLR/IL-1R associated signaling pathway. Although TRAF6 has been shown to have oncogenic activity various malignant tumors, the details remain unclear. In this study, we demonstrated that facilitates Ras (G12V) and EGF-induced cellular transformation through EGFR. Silencing of expression significantly downregulated AP-1 activity, as well MMP-2,9 after EGF stimulation. Furthermore, found an essential cutaneous squamous cell carcinoma...
Mindfulness is described as the non-judgmental awareness of experiences in present moment. The sustained practice mindfulness may also have beneficial effects on an individual's well-being. For instance, meditation effective approach for improving emotion regulation. Specifically, early stage training enhances emotional monitoring systems related to attention regulation and executive function. Reduced activity default mode network (DMN) would probably be observed corresponding attenuated...