Jianjun Liu

ORCID: 0000-0002-8987-0904
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About
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Research Areas
  • Radiopharmaceutical Chemistry and Applications
  • Medical Imaging Techniques and Applications
  • Advanced Neuroimaging Techniques and Applications
  • Alzheimer's disease research and treatments
  • Peptidase Inhibition and Analysis
  • Renal cell carcinoma treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Renal and related cancers
  • Cardiomyopathy and Myosin Studies
  • Lipid Membrane Structure and Behavior
  • Thyroid and Parathyroid Surgery
  • Flowering Plant Growth and Cultivation
  • Autoimmune and Inflammatory Disorders Research
  • Silicon Effects in Agriculture
  • Pancreatic and Hepatic Oncology Research
  • RNA Interference and Gene Delivery
  • Nanoplatforms for cancer theranostics
  • Brain Tumor Detection and Classification
  • Monoclonal and Polyclonal Antibodies Research
  • Thyroid Cancer Diagnosis and Treatment
  • Science, Research, and Medicine
  • Pediatric health and respiratory diseases
  • Environmental and Agricultural Sciences
  • Prostate Cancer Treatment and Research
  • Erythrocyte Function and Pathophysiology

Renji Hospital
2016-2024

Shanghai Jiao Tong University
2016-2024

Philippine General Hospital
2016

The First Affiliated Hospital, Sun Yat-sen University
2016

Sun Yat-sen University
2016

Shanghai Institute of Hypertension
2016

Ruijin Hospital
2016

Nanjing Drum Tower Hospital
2016

Xinjiang Institute of Water Resources and Hydropower Research
2011

Abstract Accurately predicting and selecting patients who can benefit from targeted or immunotherapy is crucial for precision therapy. Trophoblast cell surface antigen 2 (Trop2) has been extensively investigated as a pan-cancer biomarker expressed in various tumours plays role tumorigenesis through multiple signalling pathways. Our laboratory successfully developed two 68 Ga-labelled nanobody tracers that rapidly specifically target Trop2. Of the tracers, [ Ga]Ga-NOTA-T4, demonstrated...

10.1038/s44321-024-00059-5 article EN cc-by EMBO Molecular Medicine 2024-04-02

Abstract Alzheimer's disease (AD) is a common neurodegenerative disease. The histopathological changes in AD include amyloid β‐protein (Aβ) deposition, tau tangles, neuroinflammation, and neurodegeneration. Some of the pathological could be shown vivo by positron emission tomography (PET) magnetic resonance imaging (MRI) biomarkers, which play key role diagnosing AD. Fluorodeoxyglucose (FDG‐PET) can reflect predict dysfunction. Aβ‐PET sensitive for diagnosis early but cannot distinguish...

10.1002/viw.20230025 article EN cc-by View 2023-05-25

10.1007/s00259-023-06291-4 article EN European Journal of Nuclear Medicine and Molecular Imaging 2023-06-05

Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with insidious onset, rapid progression, and very poor prognosis. CD47 transmembrane protein associated the development prognosis of pancreatic cancer. The aim this study was to evaluate diagnostic value novel immunoPET tracers targeting in preclinical cancer models. association expression analyzed using Gene Expression Profiling Interactive Analysis platform. Immunohistochemical analysis tissue microarrays performed detect PDAC....

10.1021/acs.molpharmaceut.3c00311 article EN Molecular Pharmaceutics 2023-07-05

To study whether male sex is a risk factor for prognosis in patients with differentiated thyroid cancer after 131I treatment using the propensity score matching (PSM) method.From April 2016 to October 2021, 1948 postoperative aged 43 (interquartile range: 34, 54) years who received were retrospectively enrolled and divided into (n = 645) female groups 1303). The PSM method was adopted process all data reduce influence of bias confounding variables. Mann-Whitney U test χ2 used analysis....

10.1210/clinem/dgad314 article EN The Journal of Clinical Endocrinology & Metabolism 2023-06-02

Objective: To report the baseline data of Chinese patients in PROOF, an ongoing multi-country study evaluating long-term outcomes axSpA patients.Methods: PROOF is a prospective observational (ASAS classification criteria and diagnosed ≤12 months before enrollment) clinical practice over 5 years.Yearly assessments disease activity (BASDAI, ASDAS-CRP), physical function (BASFI), quality-of-life (SF-12v2), productivity (WPAI-SHP), pelvic X-ray (graded by local central readers according to NY...

10.1111/1756-185x.12961 article EN International Journal of Rheumatic Diseases 2016-09-01

Alzheimers disease (AD) is a common neurodegenerative disease. The histopathological changes of AD include amyloid β-protein (Aβ) deposition, tau tangles, neuroinflammation and neurodegeneration. Some the pathological could be shown in vivo by positron emission tomography (PET) magnetic resonance imaging (MRI) biomarkers which play key role diagnosing AD. Fluorodeoxyglucose (FDG-PET) can reflect predict dysfunction. Aβ-PET was sensitive for diagnosis early but cannot distinguish severity...

10.22541/au.167765766.60140871/v1 preprint EN Authorea (Authorea) 2023-03-01

Total variation regularized expectation maximization (TVREM) reconstruction algorithm on the image quality of gallium (68GA) prostate-specific membrane antigen-11 ([68Ga]Ga-PSMA-11) total-body positron emission tomography/computed tomography (PET/CT).Images a phantom with small hot sphere inserts and PET/CT scans 51 prostate cancer patients undergoing [68Ga]Ga-PSMA-11 were reconstructed using TVREM 5 different penalization factors between 0.09 0.45 for 20-, 40-, 60-, 120-, 300-second...

10.21037/qims-22-1341 article EN Quantitative Imaging in Medicine and Surgery 2023-07-20

Abstract A 68-year-old man with chest tightness underwent cardiac blood perfusion imaging on total-body 13 N-NH 3 PET/CT. Incidentally, mildly increased activity was observed in the left side of body tongue. Pathological diagnosis proved to be mucosal squamous cell carcinoma.

10.1097/rlu.0000000000004938 article EN Clinical Nuclear Medicine 2023-11-17
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