A5100737788- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Biopolymer Synthesis and Applications
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Drug-Induced Hepatotoxicity and Protection
- Advanced biosensing and bioanalysis techniques
- Microbial Metabolic Engineering and Bioproduction
- Glycosylation and Glycoproteins Research
- Melanoma and MAPK Pathways
- Anesthesia and Neurotoxicity Research
- Antimicrobial Peptides and Activities
- FOXO transcription factor regulation
- Microbial metabolism and enzyme function
- PARP inhibition in cancer therapy
- Fluid Dynamics and Vibration Analysis
Nanjing Agricultural University
2025
Changzhou University
2023-2025
Jilin Medical University
2024
Renji Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
First Affiliated Hospital of Wenzhou Medical University
2019-2021
Daqing Oilfield General Hospital
2021
Wenzhou Medical University
2019-2021
Union Hospital
2021
Huazhong University of Science and Technology
2014-2021
H(2)S (hydrogen sulfide), regarded as the third gaseous transmitter, is implicated in ulcerative colitis and colorectal cancers. The present study investigates effects of on cell proliferation human colon cancer HCT 116 cells SW480 cells. We identified two key enzymes, CBS CSE, for synthesis An exogenously administered donor NaHS induced a concentration-dependent manner, with optimal proliferative concentration at 200 micromol/l. administration increased Akt ERK phosphorylation. Blockade...
Ischemic stroke (IS) is the leading cause of worldwide death while discovery and effective delivery neuroprotective agents for satisfied IS treatment still challenging. In this study, we discover that celery seed (CS) derived reconstituted lipid nanoparticles (CS-rLNPs) can effectively penetrate across blood-brain barrier (BBB) with increased distribution to brain. Especially, CS-rLNPs show innate neuron-targeting ability primarily bind neuron in cerebral ischemic area, which not reported by...
The toxic effects of ZnO nanoparticles (nano-ZnO) (1-100 microg/mL) suspended in DMEM were examined human A549 cells, HepG2 skin fibroblast keratinocytes, and rat primary neuronal cells for 24 h. Nano-ZnO induced dose dependent cytotoxicity damaged cell membranes. Cell death was not mediated by reactive oxygen species (ROS) or apoptosis. DNA damage fibroblasts, cells. nano-ZnO supplemented with 10% FBS, instead serum free DMEM, also the keratinocytes. levels similar to those tested without...
Abstract Cancer cachexia is a metabolic disorder characterized by skeletal muscle wasting and white adipose tissue browning. Specific functions of several hormones, growth factors, cytokines derived from tumors can trigger cachexia. Moreover, lipolysis might explain weight loss that occurs owing to Extracellular vesicles (EVs) are involved in intercellular communication. However, whether EVs participate induced cancer has not been thoroughly investigated. Using Lewis lung carcinoma (LLC)...
18β-glycyrrhetinic acid (18β-Gly), which is extracted from licorice root, has various pharmacological properties; however, its anti-cancer effects on lung cancer cells have not been fully established.In this study, we investigated the underlying molecular mechanisms of 18β-Gly.Our results showed that 18β-Gly had significant cytotoxic and no apparent side effects. induced mitochondria-dependent apoptosis A549 cells. In addition, after treatment with 18β-Gly, intracellular reactive oxygen...
AimsRenalase, an enzyme that can metabolize catecholamine, was recently reported to attenuate the ischaemia/reperfusion (I/R)-induced cardiac injury. This work undertaken investigate functions and regulation mechanisms of renalase in protection against I/R
Pancreatic cancer (PC) is one of the most well-known malignancies with high mortality, but underlying mechanism PC remains unknown. Keratin17 (KRT17) expression has been reported in many malignancies, its functions are not clear. The aim our study was to evaluate KRT17 and potential role PC.The online databases GEPIA THPA were used identify tissues. Quantitative real-time PCR (qRT-PCR) determine cell lines. Ki67 ROS levels detected by immunofluorescence assay a...
Abstract Background Pancreatic cancer is aggressive with no symptoms until the advanced stage reached. The increased resistance of pancreatic to chemotherapy demonstrates a dilemma in clinical field. Hence, it matter great urgency develop an effective drug treat patients . Betulinic acid major triterpene isolated from spina date seed. Several studies have suggested its low toxicity and side effects malaria inflammation. However, relevant on betulinic inhibiting were insufficient molecular...
When the ultra-high-speed elevator with a double-deck car runs at high speed in hoistway, its inherent cavity space structure causes complex airflow changes. It forms an eddy current structure, significantly affecting car's stable operation. In order to solve this problem, paper first analyzes establishes full-process wind tunnel model (FDDC-WT model), and carries out experimental verification. Then, flow field well is divided into regions, vortex evolution process, velocity, pressure...
Hyperlipidemia (HLP) is a complex pathological condition results from lipid metabolism disorder, which closely related to obesity, atherosclerosis and steatohepatitis. Emodin (EM), natural anthraquinone, exhibits prominent hypolipidemic effects. However, its exact mechanism still unclear. In this study, we successfully established hyperlipidemic zebrafish model induced by 4 % high-cholesterol diet (HCD) for 10 days explored the anti-hyperlipidemic roles underlying mechanisms of EM. The...
Lipid nanoparticles (LNPs) hold great promise as carriers for developing drug delivery systems (DDSs) aimed at managing ischemic stroke (IS). Previous research has highlighted the vital role played by lipid composition and biophysical characteristics of LNPs, influencing their interactions with cells tissues. This understanding presents an opportunity to engineer LNPs tailored specifically enhanced IS treatment. We previously introduced innovative concept reconstituted (rLNPs), which not...
Breast cancer is one of the most common and lethal cancers in women. As a hub gene involved diversity tumors, ubiquitin-conjugating enzyme H10 (UbcH10), may also play some roles genesis development breast cancer. In current study, we found that expression UbcH10 was up-regulated tissues five cell lines. We established dual drug resistant line MCF-7/EPB (epirubicin)/TXT (docetaxel) lentiviral system expressing shRNA to investigate effects knockdown on chemosensitivity MCF-7/EPB/TXT cells...
We reconstructed the first genome‐scale metabolic network of plant pathogen Pectobacterium carotovorum subsp. PC1 based on its genomic sequence, annotation, and physiological data. Metabolic characteristics were analyzed using flux balance analysis (FBA), results afterwards validated by phenotype microarray (PM) experiments. The model, iPC1209, contains 2235 reactions, 1113 metabolites 1209 genes. identified 19 potential bactericide targets through a comprehensive in silico gene‐deletion...
Current investigations suggest that the Base Excision Repair (BER) system may change DNA repair capacity and affect clinical gastric cancer progression such as overall survival. However, prognostic value of BER members in remains unclear.We explored correlation between 7 individual genes, including uracil-DNA glycosylase (UNG), Single-strand-selective monofunctional 1 (SMUG1), Methyl-CpG binding domain 4 (MBD4), thymine (TDG), 8-oxoguanine (OGG1), MutY (MUTYH) Nei like (NEIL1), expression...