A5104103773- Methane Hydrates and Related Phenomena
- Seismic Waves and Analysis
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Cancer-related molecular mechanisms research
- Seismology and Earthquake Studies
- Earthquake Detection and Analysis
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Circular RNAs in diseases
- Infrared Thermography in Medicine
- MRI in cancer diagnosis
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Thermoregulation and physiological responses
- Extracellular vesicles in disease
- Platelet Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- Radiomics and Machine Learning in Medical Imaging
Shanghai University of Traditional Chinese Medicine
2025
Hebei Medical University
2021-2025
Fourth Hospital of Hebei Medical University
2021-2025
Kunming University of Science and Technology
2025
First People's Hospital of Yunnan Province
2025
Oregon Health & Science University
2014-2024
Tianjin Medical University
2024
Zunyi Medical University
2023-2024
Chinese Academy of Sciences
2024
Institute of Optics and Electronics, Chinese Academy of Sciences
2024
Objective N 6 -methyladenosine (m A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation progression via the regulation of function. This study explored biological function clinical significance gastric cancer (GC). Design The prognostic value expression was evaluated using tissue microarray immunohistochemical staining analyses a human GC cohort. role mechanism growth liver metastasis were determined vitro vivo. Results level m A significantly...
Abstract Background Pancreatic cancer is one of the most lethal human cancers. N 6 -methyladenosine (m A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role pancreatic remains elusive. Methods LC/MS was used to profile m A levels normal tissues. Bioinformatics analysis, real-time PCR, immunohistochemistry, western blotting were identify regulators cancer. The biological effects methyltransferase-like 14 (METTL14),...
Platelets are central players in atherothrombosis development coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the classical isoforms PKCalpha PKCbeta novel PKCdelta PKCtheta. Here, we used a genetic approach to definitively demonstrate role played by thrombus formation function. Thrombus vivo was attenuated Prkca-/- mice, required vitro, although isoform did...
Although microRNAs (miRNA) have been revealed as crucial modulators of tumorigenesis, our understanding their roles in renal cell carcinoma (RCC) is limited. Here we sought to identify human miRNAs that act key regulators carcinogenesis.We performed microarray-based miRNA profiling clear RCC (ccRCC) and adjacent normal tissues then explored the miR-141 both vitro vivo, which was most significantly downregulated ccRCC tissues.A total 74 were dysregulated compared with tissues. remarkably...
Ultrasound can increase tissue blood flow, in part, through the intravascular shear produced by oscillatory pressure fluctuations. We hypothesized that ultrasound-mediated increases perfusion be augmented microbubble contrast agents undergo cavitation and sought to characterize biological mediators.Contrast ultrasound imaging of hindlimb skeletal muscle femoral artery diameter measurement were performed nonischemic mice after unilateral 10-minute exposure intermittent alone (mechanical...
Abstract Aims Data on ventricular pulsed-field ablation (PFA) are sparse in the setting of chronic myocardial infarction (MI). The objective this study was to compare biophysical and histopathologic characteristics PFA healthy MI swine myocardium. Methods results Myocardial (n = 8) underwent coronary balloon occlusion survived for 30 days. We then performed endocardial unipolar, biphasic border zone a dense scar with electroanatomic mapping using an irrigated contact force (CF)-sensing...
Background— In atherosclerosis, local generation of reactive oxygen species amplifies the inflammatory response and contributes to plaque vulnerability. We used molecular imaging test whether inhibition NADPH oxidase with apocynin would reduce endothelial activation endothelial–platelet interactions, thereby interrupting progression high-risk phenotype. Methods Results— Mice deficient for both low-density lipoprotein receptor Apobec-1 were studied at 30 weeks age again after 10 or without...
Pancreatic ductal adenocarcinoma is one of the most aggressive cancers, with a 5-year survival rate less than 8%. The complicated tumor microenvironment, particularly TGF-β, provides possible convenience for progression PC cells. TGF-β regulates critical cellular processes, including autophagy. However, mechanism and effects TGF-β-mediated autophagy are still poorly understood.Bioinformatics analysis, western blot, transmission electron microscopy confocal were used to identify that TFEB key...
Abstract Endogenous cannabinoids and peripheral cannabinoid CB2 receptors ( CB2Rs ) are involved in the antinociceptive effect of electroacupuncture EA on inflammatory pain. However, it is not clear how CB2R activation contributes to . The major proinflammatory cytokines, such as tumour necrosis factor‐α TNF ‐α), interleukin‐1β IL ‐1β) ‐6, Here we determined effects expression level ‐1β, ‐6 ‐α inflamed skin tissues. Inflammatory pain was induced by injection complete F reund's adjuvant into...
Background— Stem cells are thought to enhance vascular remodeling in ischemic tissue part through paracrine effects. Using molecular imaging, we tested the hypothesis that treatment of limb ischemia with multipotential adult progenitor (MAPCs) promotes recovery blood flow recruitment proangiogenic monocytes. Methods and Results— Hind-limb was produced mice by iliac artery ligation, MAPCs were administered intramuscularly on day 1. Optical imaging luciferase-transfected indicated survived for...
Cells of the monocyte lineage are most abundant inflammatory cells found in atherosclerotic lesions. Dominance infiltrate by monocytes indicates that there is a disease-driven mechanism supporting their selective recruitment. Previous studies have demonstrated interactions between endothelial (ECs) and platelets may promote In this study, we sought to expand on knowledge using complex coculture model diseased vessel wall. Using primary human an vitro flow-based adhesion assay, secretory...
Dysregulation of regulatory B cells (Bregs), a type immunosuppressive lymphocyte, are associated with development autoimmune diseases and cancers. Bregs produce immune tolerance-inducing cell surface molecules tolerogenic cytokines (interleukin [IL]-10 transforming growth factor-beta). We previously showed that levels the inflammatory cytokine IL-18 were increased in patients pancreatic cancer. In present study study, we found cancer cell-derived increases Breg-induced immunosuppression....
// Xiuhui Shi 1, * , Hang Zhang Min Wang Xiaodong Xu 1 Yan Zhao Ruizhi He Zhou Li Feng Peng Chengjian Ming Shen Xin Xingjun Guo and Renyi Qin Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, China These authors have contributed equally to this study Correspondence to: Qin, email: ryqin@tjh.tjmu.edu.cn Guo, xjguo@tjh.tjmu.edu.cn Keywords: long noncoding RNA, AFAP1-AS1, cholangiocarcinoma, proliferation,...
Pancreatic cancer is the fourth most common cause of mortality worldwide. Furthermore, patients with pancreatic experience limited benefit from current chemotherapeutic approaches because drug resistance. Therefore, an effective therapeutic strategy for urgently required. Deguelin a natural chemopreventive that exerts potent antiproliferative activity in solid tumors by inducing cell death. However, molecular mechanisms underlying this have not been fully elucidated. Here we show deguelin...
Dosimetry for aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy of actinic keratosis was examined with an optimized fluorescence dosimeter to measure PpIX during treatment. While insufficient generation may be indicator incomplete response, there exists no standardized method quantitate production at depths in the skin clinical treatments. In this study, a spectrometer-based point probe system used sample from superficial (blue wavelength excitation) and deeper...
Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, we evaluated the prognostic values differentially expressed miRNAs and constructed a five-miRNA signature that could effectively predict patient overall survival (OS). Kaplan-Meier curves two groups based on five were notably different, showing in 10.2% 47.8% at years patients high-risk low-risk groups, respectively. ROC curve analysis...
Abstract Backgrounds Inflammation is recognized as the key pathological mechanism of type 2 diabetes. The hypoglyceamic effects berberine (BBR) are related to inhibition inflammatory response, but not completely clear. Methods polarization Raw264.7 cells and primary peritoneal macrophages were induced by LPS, then underlying mechanisms BBR explored. An model was established LPS treatment at different concentrations for time. ELISA assay used detect secretions TNF-α. RT-PCR applied M1...