A5046527141- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Memory and Neural Mechanisms
- Microbial bioremediation and biosurfactants
- Toxic Organic Pollutants Impact
- Photoreceptor and optogenetics research
- Bone Tissue Engineering Materials
- RNA modifications and cancer
- Osteoarthritis Treatment and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Neuroscience and Neural Engineering
- Knee injuries and reconstruction techniques
- Neuroendocrine regulation and behavior
- Cancer Immunotherapy and Biomarkers
- Photochromic and Fluorescence Chemistry
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Microplastics and Plastic Pollution
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Radical Photochemical Reactions
- Tendon Structure and Treatment
- Neural dynamics and brain function
Chinese University of Hong Kong
2021-2025
Prince of Wales Hospital
2023-2025
Shihezi University
2025
Shenzhen University
2023-2024
Huazhong University of Science and Technology
2018-2024
Wuxi No.2 People's Hospital
2024
Nankai University
2007-2024
Kanion Pharmaceutical (China)
2024
Nantong University
2024
Union Hospital
2022-2024
Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells, regeneration remains a great challenge in clinic. In this study, we found decellularized meniscal extracellular matrix (MECM) preserved native collagen and glycosaminoglycans which could be good guider for stem cells. Moreover, MECM significantly promoted fibrochondrocytes viability proliferation, increased the expression of type II proteoglycans...
Elevated bone resorption and diminished formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, direct effects excess glucocorticoids on turnover remains unclear. Here, we explored outcomes exogenous glucocorticoid treatment loss delayed fracture healing in mice found that reduced was a dominant feature, resulting net mass. The effect osteogenic differentiation not inhibitory; instead, they cooperated with macrophages to facilitate...
Abstract Currently, surfactants are widely distributed in the environment. As organic pollutants, their toxicities have drawn extensive attention. In this study, effects of anionic [sodium dodecyl sulphate (SDS) ], cationic [dodecyl dimethyl benzyl ammonium chloride (1227)] and non-ionic [fatty alcohol polyoxyethylene ether (AEO) ] on zebrafish larval behaviour were evaluated. Five behavioural parameters recorded using a rest/wake assay, including rest total, number bouts, bouts length,...
Background: Many microRNAs (miRs) are dysregulated in cancers, and aberrant miR expression patterns have been suggested to correlate with chemo-resistance of cancer cells. We aim study the role miR-30 family members cisplatin-resistance ovarian Methods: qRT-PCR was used compare differential levels cell line A2780 its cisplatin-resistant derivative CP70. Changes cisplatin-sensitivity miR-30a-5p- miR-30c-5p-overexpressed-CP70 cells miR-30c-5p-inhibited-A2780 were examined by CCK8 assay...
Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and application in tissue engineering.Also, subpopulations MSCs cartilage regeneration remains poorly characterized.CD146+ are identified as natural ancestors expression CD146 indicative greater pluripotency self-renewal potential.Here, we sorted a + subpopulation from adipose-derived (ADSCs) for regeneration.Methods: ADSCs were using magnetic activated sorting (MACS).Cell surface markers, viability, apoptosis...
Recognition memory provides the ability to distinguish familiar from novel objects and places, is important for recording updating events guide appropriate behavior. The hippocampus (HPC) medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but nature of HPC-mPFC interactions, its impact on local circuits mediating this process not known. Here we show that novelty discrimination accompanied with higher theta activity (4-10 Hz) increased c-Fos expression these...
Bone grafting is frequently conducted to treat bone defects caused by trauma and tumor removal, yet with significant medical socioeconomic burdens. Space-occupying substitutes remain challenging in the control of osteointegration, meanwhile activation endogenous periosteal cells using non-space-occupying implants promote new formation becomes another therapeutic strategy. Here, we fabricated a magnesium-based artificial bandage optimal micropatterns for activating periosteum-associated...
Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, we evaluated the prognostic values differentially expressed miRNAs and constructed a five-miRNA signature that could effectively predict patient overall survival (OS). Kaplan-Meier curves two groups based on five were notably different, showing in 10.2% 47.8% at years patients high-risk low-risk groups, respectively. ROC curve analysis...
Soil contamination with multiple heavy metals is a global environmental issue that poses serious threat to public health and ecological safety. Biochar passivation an efficient economical technology prevent metal of Cd; however, its effects on compound-contaminated weakly alkaline soil remain unclear. Further, the mechanisms mediating immobilization biochar have not been evaluated. In this study, three treated at different pyrolytic temperatures [300°C (BC300), 400°C (BC400), 500°C (BC500)]...
Abstract The healing of bone defects after debridement in medication‐related osteonecrosis the jaw (MRONJ) is a challenging medical condition with impaired angiogenesis, susceptible infection, and pro‐inflammatory responses. Magnesium (Mg) nanocomposite hydrogel developed to specifically tackle multiple factors involved MRONJ. Mg‐oxide nanoparticles tune gelation kinetics reaction between N‐hydroxysuccinimide‐functionalized hyperbranched poly (ethylene glycol) proteins. This allows an...
// Xiuhui Shi 1 , Yan Zhao Ruizhi He Min Zhou Shutao Pan Shuo Yu Xie Xu Li Wang Xingjun Guo and Renyi Qin Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, China Correspondence to: Qin, email: ryqin@tjh.tjmu.edu.cn Guo, xjguo@tjh.tjmu.edu.cn Keywords: long noncoding RNA; pancreatic adenocarcinoma; TCGA; ceRNA; prognosis Received: August 23, 2017 Accepted: February 01,...
Synchronized activity in neural circuits, detected as oscillations the extracellular field potential, has been associated with learning and memory. Neural circuits basolateral amygdala (BLA), a mid-temporal lobe structure, generate specific frequency bands to mediate emotional memory functions. However, how BLA distinct is not known. Of these, sharp-waves (SWs) are repetitive, brief transitions that contain low-frequency (<20 Hz) envelope, often coupled ripples (100-300 Hz), have...
Abstract Bioceramics provide promising tactics for wound healing, yet the on‐shelf products are still unmet, especially skin appendages regeneration. Herein, inorganic magnesium silicate sprays (MSS) as mineral factors to overcome existing challenges is proposed. Results indicate MSS can be synthesized by a green method without organic solvents, templates, calcination, and harmful by‐products. With amorphous phase, nanoscale, high specific surface area, reveal an improved pH‐responsive...
Here, we report that both nano-silica (SiO<sub>2</sub>-NPs) and reserpine can elicit depression-like behavior in adult zebrafish a novel tank test.
Abstract Uridine‐cytidine kinases (encoded by UCK1, UCKL1 , and UCK2 ) catalyze the phosphorylation of uridine cytidine to monophosphate (UMP) (CMP). In this study, using data from Cancer Genome Atlas (TCGA), we analyzed expression profile uridine‐cytidine kinase genes in hepatocellular carcinoma (HCC), their prognostic value, epigenetic alterations associated with dysregulation. Results showed that but not UCK1 were significantly upregulated HCC tissues than adjacent normal tissues. Only...